Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.

Abstract: A method and system for correcting a difference in contrast agent density in a sequence of contrast-enhanced image frames. A reference image frame is defined in the sequence of contrast-enhanced image frames, and segmentation is performed on the reference image frame to determine a location of a region of interest within the reference image frame. The region of interest is a region of the reference image frame that contains contrast agent. Other image frames in the sequence of contrast-enhanced images are corrected based on a difference in contrast agent density/image intensity in the region of interest relative to the region of interest in the reference image frame.

Abstract: A well construction method in which a drilled bore is lined with a plurality of successively smaller diameter sections of bore-lining tubing including casing sections a liner section is provided. A liner is provided with an inner string extending to a distal end of the liner. The liner and the inner string are run into a distal section of a drilled bore. Settable material is pumped from surface through the inner string and through the distal end of the liner to partially fill an outer annulus surrounding the liner. Fluid displaced from the outer annulus and a portion of the settable material is permitted to flow from the outer annulus through a port in the liner and into an inner annulus between the inner string and the liner.

Abstract: A computing device is provided, including one or more processing devices, one or more temperature sensors, a fan, and a fan tachometer. The one or more processing devices may be configured to execute an application program. While executing the application program, the one or more processing devices may be further configured to collect performance data including temperature data received from the one or more temperature sensors and fan speed data received from the fan tachometer. The one or more processing devices may be further configured to generate a fan control signal at least in part by applying a machine learning model to the performance data. The one or more processing devices may be further configured to control the fan according to the fan control signal.

Abstract: Described herein are compounds of Formula I, wherein the variables are defined herein, their use as HSD17B13 inhibitors and/or degraders, pharmaceutical compositions containing such compounds and their use to treat, for example, NAFLD and NASH.

Abstract: An exercise device is provided using, for example, handles, connected to cords that increase in tension as the handles are pulled. The tension may be provided using elasticity of the cords or by an actuator, for example powered by an electric motor. Pulleys allow adequate extension while remaining compact enough to fit in a standard height room and allowing accessibility to components. Upper and forward pulleys may be used. The upper pulleys may be displaced from potential obstacles, including the forward pulleys.

Abstract: A biocidal material includes a carrier, a plurality of copper-containing glass particles, and at least one co-biocide selected from isothiazolinones, bicyclic oxazolidines, and bromine nitrogen-based compounds. A minimum bactericidal concentration (MBC) of a combination of the at least one co-biocide and the plurality of copper-containing glass particles is less than an MBC of the at least one co-biocide in the absence of the plurality of copper-containing glass particles.

Abstract: A compact valve block for a chemical container wherein the coaxial valve block has a housing that can accommodate three valve control mechanisms thus allowing for quick and effective purging without the need for an additional external conduit, valves, and coaxial injector. The advantage is a greatly reduced amount of wetted surface area inside the valve block leading to a significant decrease in the time it takes to purge a system thus allowing for quicker times to change chemical containers.

Abstract: Provided are specific leukotriene synthesis inhibitor compounds and pharmaceutical compositions comprising the compounds and methods of using the compounds and the pharmaceutical compositions in treating, for example, inflammatory diseases or conditions.

Abstract: Speech recognition may be improved by generating and using a topic specific language model. A topic specific language model may be created by performing an initial pass on an audio signal using a generic or basis language model. A speech recognition device may then determine topics relating to the audio signal based on the words identified in the initial pass and retrieve a corpus of text relating to those topics. Using the retrieved corpus of text, the speech recognition device may create a topic specific language model. In one example, the speech recognition device may adapt or otherwise modify the generic language model based on the retrieved corpus of text.

Abstract: A data file system includes one or more files about a patient wearing a wearable cardiac defibrillator (WCD) system that has been assigned to them. The one or more files contain at least one patient identifier of the patient, compliance data about a history of the patient's wearing the WCD system, and possibly other data. The data file system can be accessed through a communication network when the patient uses a communication device. When so accessed, some of the contents can be viewed on a screen of the device, for example in the form of a website.

Abstract: A mobile image capture device is provided that can include an image capture system operable to capture image frames and be configured to: provide a live video stream for display in a viewfinder portion of a user interface that depicts at least a portion of a current field of view of the image capture system; store a video segment from the live video stream in a temporary image buffer that includes a plurality of image frames captured by the image capture system; receive a user input that is directed to the viewfinder portion of the user interface that requests a rewind operation; and, in response to such user input, perform the rewind operation in the viewfinder portion of the user interface with respect to the video segment in which at least two of the image frames of the video segment can be provided for display in the user interface in a reverse chronological order.

Abstract: The disclosure is generally directed to systems and methods associated with communicating privacy rights pertaining to data captured from a vehicle. An example method executed by a processor of a data capture apparatus in a vehicle can include capturing an image. In an example scenario, the image may include an individual who is located outside the vehicle. Furthermore, in some cases, the image can be a part of a video clip containing multiple images. The method further includes generating an identifier for identifying the image(s). The identifier can be a machine-readable symbol such as, for example, a QR-code symbol or a barcode. A notification that includes the identifier may be generated and conveyed to the individual for use by the individual to exercise his/her rights to privacy with respect to the images in which he/she is present.

Abstract: In an aspect a computer-implemented method is described. The method may include: causing a point-of-sale terminal processing a transaction to display a machine-readable code, the machine-readable code encoding a web address; receiving a request from a device that scanned the machine-readable code, the request received at the web address and the request including data; determining, based on data encoded in the machine-readable code and data included in the request, that the transaction may be processed using a value-added service; and in response to determining that the transaction may be processed using the value-added service, enabling completion of the transaction using the value-added service.

Abstract: Systems and methods for phenotyping clinical data are provided. The method includes obtaining episodic records comprising unstructured clinical data from an electronic medical record (EMR) or electronic health record (EHR) for patients. The method also includes filtering the episodic records by language pattern recognition to identify episodic records that each includes an expression related to a clinical condition. The method also includes splitting each episodic record to obtain snippets comprising tokens. The method also includes predicting if an episodic record represents an instance of the clinical condition using a trained classifier. The trained classifier includes an aggregation function that aggregates the snippets to output a corresponding representation for the episodic record, and an interpretation function that interprets the corresponding representation to output a corresponding prediction for whether the episodic record represents an instance of the clinical condition.

Abstract: A head unit device for controlling motion of an object includes a chamber filled with a shear thickening fluid (STF) and a piston. The piston is housed within the chamber and exerts pressure against the STF from a force applied to the piston from the object. The STF is configured to have a decreasing viscosity in response to a first range of shear rates and an increasing viscosity in response to a second range of shear rates. The piston includes at least one piston bypass between opposite sides of the piston that controls flow of the STF between the opposite sides of the piston to selectively react with a shear threshold effect of the first range of shear rates or the second range of shear rates.

Abstract: Described herein are lateral III-N (e.g., GaN) devices having a III-N depleting layer. A circuit includes a depletion-mode transistor with a source connected to a drain of an enhancement-mode transistor. The gate of the depletion-mode transistor and the gate of the enhancement-mode transistor are biased at zero volts, and the drain of the depletion-mode transistor is biased at positive voltage to block a current in a forward direction. Then, the bias of the gate of the enhancement-mode transistor is changed to a first voltage greater than the threshold voltage of the enhancement-mode transistor and a first current is allowed to flow through the channel in a forward direction. Then, the bias of the gate of the depletion-mode transistor is changed to a second voltage and a second current is allowed to flow through the channel in a forward direction where the second current is greater than the first current.

Abstract: A formation tester comprises a body having an outlet; a probe extendable from the body and having a sealing pad; and a flow line within the body, wherein the flow line has an entry end connectable to the probe and has an exit end connectable to the outlet in the body; and a reactive filter material in the flow line downstream of the entry end of the flow line, wherein the reactive filter material sorbs and entraps an analyte in a wellbore fluid.

Abstract: Removal of PII is provided. Sensor data is captured using sensors of a vehicle. Object detection is performed on the sensor data to create a sematic labeling of objects in the sensor data. A model is utilized to classify regions of the sensor data with a public or private labeling according to the sematic labeling and a PII filter corresponding to a jurisdiction of a current location of the vehicle. The sensor data is utilized in accordance with the public or private labeling.