Patents by Inventor David Michael Blum

David Michael Blum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tubulin inhibitor and process for its preparation
    Patent number: 7501423
    Abstract: The invention provides 6-chloro-5-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrimidin-4-amine hemifumarate which is a tubulin inhibitor useful in the treatment of cancer and processes of making said hemifumarate.
    Type: Grant
    Filed: June 4, 2007
    Date of Patent: March 10, 2009
    Assignee: Wyeth
    Inventors: David Michael Blum, Yanzhong Wu, Jean Schmid, Timothy John Doyle, Jay Thomas Afragola
  • Process for preparation of 4-amino-3-quinolinecarbonitriles
    Patent number: 7297795
    Abstract: This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: November 20, 2007
    Assignee: Wyeth Holdings Corporation
    Inventors: Karen Wiggins Sutherland, Gregg Brian Feigelson, Diane Harris Boschelli, David Michael Blum, Henry Lee Strong
  • Tubulin inhibitor and process for its preparation
    Patent number: 7244736
    Abstract: The invention provides 6-chloro-5-{2,6-difluoro-4-[3-(methylamino)propoxy]phenyl}-2-pyrazin-2-yl-N-[(1S)-2,2,2-trifluoro-1-methylethyl]pyrimidin-4-amine hemifumarate which is a tubulin inhibitor useful in the treatment of cancer and processes of making hemifumarate compounds and compositioning of the present invention.
    Type: Grant
    Filed: June 12, 2006
    Date of Patent: July 17, 2007
    Assignee: Wyeth
    Inventors: David Michael Blum, Yanzhong Wu, Jean Schmid, Timothy John Doyle, Jay Thomas Afragola