Abstract: The present invention relates to systems and methods for hypothetical testing of a supply chain optimization. The computerized method for hypothetical optimization of a supply chain receives a hypothetical optimization query, generates variable definitions responsive to the query, generates scope definitions responsive to the query, generates presentation definitions and generates an optimization parameter set using the variable definitions and the scope definitions. The parameter set is used to optimize a hypothetical supply chain via an artificial intelligence (AI) modeling platform. One or more recommendations are generated based upon the optimized hypothetical supply chain.

Abstract: The present invention relates to systems and methods for ingesting of raw client data into a supply chain optimization system. The client enterprise data system (EDS) provides raw data, typically in tabular format across many files, to a data management module of the optimization system. This data is then profiled. and a set of mapping AI models is applied to the profiled data. Each of the plurality of mapping AI models corresponds to a single input feature of the optimization model. As the mapping models are applied, a live preview is generated. This live preview is reviewable by a human operator, and human input can be provided. When there is input, the individual mapping model is updated (without impacting the other mapping models), and a new live preview for that given feature is generated. The resulting standardized feature set may be consumed by the supply chain optimization model.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in medicine; and methods of treating patients with such compounds; wherein A, W, R5, n, Z, X, Y and B are as defined herein. The present invention also relates to compounds useful as synthetic intermediates of compounds of formula (I).

Abstract: A hydraulic screw tensioning device includes a tubular body, with a through opening and an annular cylinder chamber surrounding the through opening and a tubular piston movably supported in the tubular body and connectable to a screw to be tensioned. The tubular piston includes a stepped outer portion and divides the annular cylinder chamber into a first pressure chamber and a second pressure chamber. The second pressure chamber is closed by an annular end cap secured to the tubular body. The first pressure chamber is connectable to a pressure source for hydraulic fluid. The second pressure chamber is connectable to a pressure source for a compressible medium via a conduit connector mounted on the annular end cap. The conduit connector extends radially in relation to a geometric axis (A-A) of the tubular body. A damage protecting structure is provided to protect the conduit connector against accidental physical damage.

Abstract: The present invention relates to systems and methods for intelligently optimizing supply chain is provided. In particular, the systems and methods provide the capability to configure supply chain systems so as to: balance between cost and service is optimized and profitability maximized; configure system parameters to respond to both current and future risks; ensure that variability is built into plans enabling maximized efficiency; and human error and bias are eliminated from the planning process such that pro-active rather than reactive behavior becomes the norm.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: A hydraulic screw tensioning device includes a tubular body, with a through opening and an annular cylinder chamber surrounding the through opening and a tubular piston movably supported in the tubular body and connectable to a screw to be tensioned. The tubular piston includes a stepped outer portion and divides the annular cylinder chamber into a first pressure chamber and a second pressure chamber. The second pressure chamber is closed by an annular end cap secured to the tubular body. The first pressure chamber is connectable to a pressure source for hydraulic fluid. The second pressure chamber is connectable to a pressure source for a compressible medium via a conduit connector mounted on the annular end cap. The conduit connector extends radially in relation to a geometric axis (A-A) of the tubular body. A damage protecting structure is provided to protect the conduit connector against accidental physical damage.

Abstract: The present invention provides compounds of formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are as defined herein.

Abstract: The present invention relates to systems and methods for intelligently optimizing supply chain is provided. In particular, the systems and methods provide the capability to configure supply chain systems so as to: balance between cost and service is optimised and profitability maximised; configure system parameters to respond to both current and future risks; ensure that variability is built into plans enabling maximised efficiency; and human error and bias are eliminated from the planning process such that pro-active rather than reactive behaviour becomes the norm.

Abstract: The present invention provides compounds of formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, and, n, are as defined herein.

Abstract: The present invention provides compounds of formula (I): Formula (I) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, Y, n, R1, R2A, R2B, R3 and *1 are as defined herein.

Abstract: The present invention provides compounds of formula (I) or (Ia) compositions comprising such compounds; the use of such compounds in therapy; and methods of treating patients with such compounds; wherein A, B, n, R2, R3, R4, R5, and R6 are as defined herein.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: The present invention provides compounds of formula (I), compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, R12, R13, A, L, B, n, W, X, Y and Z are as defined herein.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: The present invention provides compounds of formula (I), compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, R12, R13, A, L, B, n, W, X, Y and Z are as defined herein.

Abstract: The present invention provides a selection of compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.

Abstract: The present invention provides a selection of compounds of formula (I): (I) compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R5, R6, R7, A, B, W, X, Y and Z are as defined herein.