Patents by Inventor David Michael Goldstein

David Michael Goldstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazole derivatives-p38 MAP kinase inhibitors
    Patent number: 6979693
    Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: December 27, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
  • 6-alkoxy-pyrido-pyridine
    Patent number: 6965030
    Abstract: The present invention provides compounds of the Formula I: wherein R1 is alkyl, cycloalkyl, cycloalkylalkyl, or —CH2-alkenyl, X1 is O, NH, N(alkyl), S or —C(?O), Z is N or CH; and R2 and R3 are as defined herein, pharmaceutical compositions comprising same, and methods for their use.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: November 15, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: David Michael Goldstein, Julie Anne Lim
  • Imidazo-substituted compounds as p38 kinase inhibitors
    Patent number: 6949560
    Abstract: The present invention discloses compounds corresponding to formula I: wherein A, Z, Z1, Y, R1 and R2 are as defined in the specification, as well as pharmaceutical formulations, methods of making and uses thereof.
    Type: Grant
    Filed: April 3, 2003
    Date of Patent: September 27, 2005
    Assignee: Roche Palo Alto LLC
    Inventors: David Michael Goldstein, Ronald Charles Hawley, Alfred Sui-Ting Lui, Eric Brian Sjogren
  • Methods of treating p38 kinase-mediated disorders with pyrido[2,3-d]pyrimidin-7-one compounds
    Patent number: 6861423
    Abstract: Disorders mediated by p38 kinase inhibitors are treated with compounds of the formula: or salts thereof, wherein: R1 is hydrogen or alkyl; R2 is substituted cycloalkyl, heterosubstituted cycloalkyl, helcroalkylsubstituted cycloalkyl, heterosubstituted cycloalkyl-alkly, heterocyclyl, heterocyclyl spiro cycloalkyl, aralkoxy, alkoxy, -alkylene-S(O)n-alkyl (where is 1 or 2) or —SO2Ar2; R3 is hydrogen, amino, monoalkylamino, dialkylamino, acylamino, —NR8—C(?O)—Rb (where Ra is hydrogen or alkyl and Rh is heterocyclyl or heteroalkyl), alkyl, cycloalkyl, phthalimidoalkyl, aryl, aralkyl, haloalkyl, heteroalkyl, cyanoalkyl, -alkylene-C(O) R (where R is hydrogen, alkyl, hydroxy, alkoxy, amino, monoalkylamino or dialkylamino) or acyl; and each of Ar1 and Ar2 is independently aryl.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: March 1, 2005
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • Substituted 7-azaquinazoline compounds useful as p38 kinase inhibitors
    Publication number: 20040209903
    Abstract: Compounds having the formula (I) or (II), 1
    Type: Application
    Filed: April 15, 2004
    Publication date: October 21, 2004
    Inventors: Nolan James Dewdney, David Michael Goldstein
  • Substituted quinazoline compounds useful as P38 kinase inhibitors
    Publication number: 20040209904
    Abstract: Compounds having the formula (I), 1
    Type: Application
    Filed: April 15, 2004
    Publication date: October 21, 2004
    Inventors: James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl, Teresa Alejandra Trejo-Martin
  • 7-oxo-pyridopyrimidines (II)
    Publication number: 20040192709
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: April 1, 2004
    Publication date: September 30, 2004
    Applicant: Syntex (U.S.A.) LLC
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Patent number: 6753427
    Abstract: The present invention provides compounds of the formula: a prodrug or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3 and Ar1 are those defined herein, and methods for preparation and uses thereof.
    Type: Grant
    Filed: December 10, 2002
    Date of Patent: June 22, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 6-Substituted pyrido-pyrimidines
    Publication number: 20040116698
    Abstract: The present invention provides compounds of the Formula I and II: 1
    Type: Application
    Filed: November 25, 2003
    Publication date: June 17, 2004
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl
  • 6-alkoxy-pyrido-pyrimidines
    Publication number: 20040038999
    Abstract: The present invention provides compounds of the Formula I: 1
    Type: Application
    Filed: August 5, 2003
    Publication date: February 26, 2004
    Inventors: David Michael Goldstein, Julie Anne Lim
  • Aminopyrrole compounds
    Patent number: 6696471
    Abstract: The present invention provides an aminopyrrole compound of the formula: a prodrug, individual isomer, a mixture of isomers or a pharmaceutically acceptable salt thereof, where R1, R2, Ar1 and Ar2 are those defined herein. The present invention also provides methods of using and preparing the aminopyrrole compounds of Formula I.
    Type: Grant
    Filed: August 29, 2002
    Date of Patent: February 24, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: David Michael Goldstein, David Mark Rotstein
  • 6-substituted pyrido-pyrimidines
    Patent number: 6696566
    Abstract: The present invention provides compounds of the Formula I and II: wherein R1, R3, W, Z, X1, X2, Ar1, R8 and R9 are as defined herein, and methods and intermediates for their preparation and uses thereof.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: February 24, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl
  • Imidazo-substituted compounds as p38 kinase inhibitors
    Publication number: 20030232847
    Abstract: The present invention discloses compounds corresponding to formula I: 1
    Type: Application
    Filed: April 3, 2003
    Publication date: December 18, 2003
    Inventors: David Michael Goldstein, Ronald Charles Hawley, Alfred Sui-Ting Lui, Eric Brian Sjogren
  • Alkylamino-substituted bicyclic nitrogen heterocycles
    Patent number: 6642241
    Abstract: Alkylamino-substituted dihydropyrimido[4,5-d]pyrimidinone derivatives are provided which are useful as inhibitors of p38, along with a process for their manufacture and pharmaceutical preparations containing them.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: November 4, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: James Patrick Dunn, David Michael Goldstein, William Harris, Ian Edward David Smith, Teresa Rosanne Welch
  • p38 map kinase inhibitors
    Patent number: 6630485
    Abstract: The present invention relates to compounds of Formula (I) that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.
    Type: Grant
    Filed: April 19, 2001
    Date of Patent: October 7, 2003
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Soan Cheng, David Michael Goldstein, Teresa Alejandra Trejo Martin, Eric Brian Sjogren
  • 6-Substituted pyrido-pyrimidines
    Publication number: 20030171584
    Abstract: The present invention provides compounds of the Formula I and II: 1
    Type: Application
    Filed: February 11, 2002
    Publication date: September 11, 2003
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Christoph Martin Stahl
  • 7-oxo-pyridopyrimidines (I)
    Publication number: 20030153586
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: August 29, 2002
    Publication date: August 14, 2003
    Applicant: Syntex (U.S.A) LLC
    Inventors: Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • 7-oxo-pyridopyrimidines (II)
    Publication number: 20030144307
    Abstract: The present invention provides compounds of the formula: 1
    Type: Application
    Filed: December 10, 2002
    Publication date: July 31, 2003
    Inventors: Humberto Bartolome Arzeno, Jian Jeffrey Chen, James Patrick Dunn, David Michael Goldstein, Julie Anne Lim
  • p38 MAP kinase inhibitors
    Publication number: 20030139462
    Abstract: The present invention relates to compounds of Formula (I) 1
    Type: Application
    Filed: September 17, 2002
    Publication date: July 24, 2003
    Inventors: Soan Cheng, David Michael Goldstein, Teresa Alejandra Trejo Martin, Eric Brian Sjogren
  • Aminopyrrole compounds
    Publication number: 20030130319
    Abstract: The present invention provides an aminopyrrole compound of the formula: 1
    Type: Application
    Filed: August 29, 2002
    Publication date: July 10, 2003
    Applicant: Syntex (U.S.A.) LLC
    Inventors: David Michael Goldstein, David Mark Rotstein