Abstract: A biocontainment assembly for use with a patient suspected of having or diagnosed with a transmissible disease(s) capable of respiratory, airborne, contact, or droplet transmission includes a housing configured to be positioned over and at least partially enclose a head, neck, and/or torso of the patient. A sidewall of the housing includes an open portion contiguous with an at least partially pen bottom portion of the housing, sized to fit over at least a portion of the head, neck, and/or a torso of the patient. The housing also includes an airflow opening for evacuating fluid from an interior defined by the housing. The assembly also includes a drape configured to extend across the open portion of the sidewall having a first portion removably connected to the housing and an opposing second portion configured to be draped over the torso, abdomen, waist, and/or legs of the patient.