Abstract: A system and method provides for multi-party communication including engaging a network communication engine from a mobile communication interface and providing a user identification and a location indicator to the network communication engine. The method and system further includes receiving in the mobile communication interface a plurality of communication channels based on at least one of: the user identification and the location indicator and in response to a user selection of a selected communication channel, transmitting a channel engagement request to the network communication engine requesting connection of the user to the selected communication channel.

Abstract: A system and method for multi-party communication includes determining a trending common identifier within a media platform and generating a communication channel within a communication platform based on the common identifier. The method and system includes, in response to a join request from each of a plurality of users, connecting the plurality of users to the communication channel, where the communication channel is an open communication channel for active audio communication between the plurality of users across the communication platform and facilitating audio communication between the plurality of users, including providing a visual display on the communication platform, including visual display of the active audio communication across the communication platform.

Abstract: A system and method provides for multi-party communication including engaging a network communication engine from a mobile communication interface and providing a user identification and a location indicator to the network communication engine. The method and system further includes receiving in the mobile communication interface a plurality of communication channels based on at least one of: the user identification and the location indicator and in response to a user selection of a selected communication channel, transmitting a channel engagement request to the network communication engine requesting connection of the user to the selected communication channel.

Abstract: A system and method for multi-party communication includes determining a trending common identifier within a media platform and generating a communication channel within a communication platform based on the common identifier. The method and system includes, in response to a join request from each of a plurality of users, connecting the plurality of users to the communication channel, where the communication channel is an open communication channel for active audio communication between the plurality of users across the communication platform and facilitating audio communication between the plurality of users, including providing a visual display on the communication platform, including visual display of the active audio communication across the communication platform.

Abstract: A system and method provides for content management for a networked communication platform, including receiving a communication connection with a user, such as via a networked connection. The method and system includes a communication platform having executable operations for facilitating a multi-party conference with a conference engine that receives both an audio/video stream from the user, as well as data relating to the user interface operations. Concurrently, the data stream and the audio/video stream are transmitted to a data engine. The facilitates an online conference with two more users, the data engine processes the feeds external from the conference itself, allowing for recordation.

Abstract: A system and method provides for content management for a networked communication platform, including receiving a communication connection with a user, such as via a networked connection. The method and system includes a communication platform having executable operations for facilitating a multi-party conference with a conference engine that receives both an audio/video stream from the user, as well as data relating to the user interface operations. Concurrently, the data stream and the audio/video stream are transmitted to a data engine. The facilitates an online conference with two more users, the data engine processes the feeds external from the conference itself, allowing for recordation.

Abstract: A system and method provides for content management for a networked communication platform, including receiving a communication connection with a user, such as via a networked connection. The method and system includes a communication platform having executable operations for facilitating a multi-party conference with a conference engine that receives both an audio/video stream from the user, as well as data relating to the user interface operations. Concurrently, the data stream and the audio/video stream are transmitted to a data engine. The facilitates an online conference with two more users, the data engine processes the feeds external from the conference itself, allowing for recordation.

Abstract: A system and method provides for content management for a networked communication platform, including receiving a communication connection with a user, such as via a networked connection. The method and system includes a communication platform having executable operations for facilitating a multi-party conference with a conference engine that receives both an audio/video stream from the user, as well as data relating to the user interface operations. Concurrently, the data stream and the audio/video stream are transmitted to a data engine. The facilitates an online conference with two more users, the data engine processes the feeds external from the conference itself, allowing for recordation.

Abstract: A system and method for multi-party communication includes determining a trending common identifier within a media platform and generating a communication channel within a communication platform based on the common identifier. The method and system includes, in response to a join request from each of a plurality of users, connecting the plurality of users to the communication channel, where the communication channel is an open communication channel for active audio communication between the plurality of users across the communication platform and facilitating audio communication between the plurality of users, including providing a visual display on the communication platform, including visual display of the active audio communication across the communication platform.

Abstract: A system and method provides for multi-party communication including engaging a network communication engine from a mobile communication interface and providing a user identification and a location indicator to the network communication engine. The method and system further includes receiving in the mobile communication interface a plurality of communication channels based on at least one of: the user identification and the location indicator and in response to a user selection of a selected communication channel, transmitting a channel engagement request to the network communication engine requesting connection of the user to the selected communication channel.

Abstract: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol)dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.

Abstract: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol)dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.

Abstract: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes a carboxyl group-containing (meth)acrylate monomer, a cross-linking (di- or higher-functional) (meth)acrylate monomer, and a hydrophilic monomer capable of polymerizing with the carboxyl group-containing (meth)acrylate monomer and the cross-linking (meth)acrylate monomer. The swellable (meth)acrylate layer has an equilibrium water content in water of between about 5% and about 70%. The conjugated peptide may include an RGD amino acid sequence.

Abstract: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol) dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.

Abstract: A cell culture article including a pre-blocked, peptide-modified, polymer surface of the formula (I), where AAj represents at least one covalently bonded peptide, j is an integer of from 5 to 50, m, n, o, Sur, X, R, R?, and the mer ratio (m-o:n:o), including salts thereof, are as defined herein. Methods for making and using the cell culture article, as defined herein, are also disclosed.

Abstract: Functionalized peptide monomers, peptides that have been functionalized to contain a polymerization moiety, are disclosed. The use of these functionalized peptide monomers to form peptide polymers which are useful as synthetic surfaces capable of supporting culture of cells in culture, particularly cells that will be used therapeutically, is also disclosed. Methods of making the surfaces and methods of using the surfaces are also disclosed.

Abstract: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes a carboxyl group-containing (meth)acrylate monomer, a cross-linking (di- or higher-functional) (meth)acrylate monomer, and a hydrophilic monomer capable of polymerizing with the carboxyl group-containing (meth)acrylate monomer and the cross-linking (meth)acrylate monomer. The swellable (meth)acrylate layer has an equilibrium water content in water of between about 5% and about 70%. The conjugated peptide may include an RGD amino acid sequence.

Abstract: Synthetic surfaces capable of supporting culture of eukaryotic cells including stem cells and undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a polypeptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes a carboxyl group-containing (meth)acrylate monomer, a cross-linking (di- or higher-functional) (meth)acrylate monomer, and a hydrophilic monomer capable of polymerizing with the carboxyl group-containing (meth)acrylate monomer and the cross-linking (meth)acrylate monomer. The swellable (meth)acrylate layer has an equilibrium water content in water of between about 5% and about 70%. The conjugated peptide may include an RGD amino acid sequence.

Abstract: Synthetic surfaces capable of supporting culture of undifferentiated human embryonic stem cells in a chemically defined medium include a swellable (meth)acrylate layer and a peptide conjugated to the swellable (meth)acrylate layer. The swellable (meth)acrylate layer may be formed by polymerizing monomers in a composition that includes hydroxyethyl methacrylate, 2-carboxyehylacrylate, and tetra(ethylene glycol) dimethacrylate. The conjugated peptide may include an amino acid sequence of XaanProGlnValThrArgGlyAspValPheThrMetPro, where n is an integer from 0 to 3 and where Xaa is any amino acid. Further, disclosed herein is a swellable (meth)acrylate synthetic surface which can be sterilized by gamma irradiation.

Abstract: Plasma treated cyclic polyolefin copolymer surfaces having enhanced binding density for binding biologically active agents and cells are provided. These plasma treated cyclic polyolefin copolymer surfaces may be further enhanced for binding biologically active agents or cells by the application of conjugates. Methods of making and characterizing treated polymer surfaces are also provided.