Patents by Inventor David Mikulis

David Mikulis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11998351
    Abstract: An apparatus and method for assessing vascular compliance in subjects with multiple sclerosis using sequential gas delivery is provided. The apparatus includes a gas delivery device and a processor. The processor controls the gas delivery device to deliver a first and second gas during a single inspiration. The first gas contains a mixture of oxygen and carbon dioxide necessary to target an end-tidal concentration of the two gases. The second gas includes a concentration of carbon dioxide equal to the target end-tidal concentration of carbon dioxide.
    Type: Grant
    Filed: August 21, 2020
    Date of Patent: June 4, 2024
    Assignee: THORNHILL SCIENTIFIC INC.
    Inventors: Joseph Arnold Fisher, James Duffin, Olivia Sobczyk, David Mikulis
  • Patent number: 11880989
    Abstract: Z maps combined with a standardized stimulus in the form of a targeted arterial partial pressures of carbon dioxide provide surprisingly enhanced images for the assessment of pathological CVR. For example, the z-map assessment of patients with known steno-occlusive diseases of the cervico-cerebral vasculature showed an enhanced resolution of the presence, localization, and severity of the pathological CVR. Z-map have been found to be useful to reduce the confounding effects of test-to-test, subject-to-subject, and platform-to-platform variability for comparison of CVR images showing the importance of combining this analysis with the standardized stimulus.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: January 23, 2024
    Assignee: THORNHILL SCIENTIFIC INC.
    Inventors: Joseph Fisher, Olivia Sobczyk, Adrian P. Crawley, Julien Poublanc, Kevin Sam, Daniel M. Mandell, David Mikulis, James Duffin
  • Publication number: 20170236294
    Abstract: Z maps combined with a standardized stimulus in the form of a targeted arterial partial pressures of carbon dioxide provide suprisingly enhanced images for the assessment of pathological CVR. For example, the z-map assessment of patients with known steno-occlusive diseases of the cervico-cerebral vasculature showed an enhanced resolution of the presence, localization, and severity of the pathological CVR. Z-map have been found to be useful to reduce the confounding effects of test-to-test, subject-to-subject, and platform-to-platform variability for comparison of CVR images showing the importance of combining this analysis with the standardized stimulus.
    Type: Application
    Filed: October 24, 2016
    Publication date: August 17, 2017
    Inventors: Joseph Fisher, Olivia Sobczyk, Adrian P. Crawley, Julian Poublanc, Kevin Sam, Daniel M. Mandell, David Mikulis, James Duffin
  • Publication number: 20150047634
    Abstract: There is provided herein devices for delivering hydrogen to a subject comprising a flow path including a breather bag and an inhalation outlet for engagement with the subject respiratory system; and a breathing gas supply source comprising hydrogen gas and in fluid communication with the flow path. Also provided are devices for the cutaneous delivery of hydrogen.
    Type: Application
    Filed: March 18, 2013
    Publication date: February 19, 2015
    Inventors: Kieran Murphy, David Mikulis, Joseph Barfett