Patents by Inventor David Milesi

David Milesi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7790385
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Grant
    Filed: June 28, 2007
    Date of Patent: September 7, 2010
    Assignee: Elitech Holding B.V.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • Patent number: 7553643
    Abstract: The present invention provides a novel method for nucleic acid amplification. The method includes contacting the sample with at least one forward primer and at least one reverse primer, an AP endonuclease, and a nucleic acid polymerase. under conditions sufficient to allow the forward and reverse primers to hybridize to the target nucleic acid and form a reaction mixture, wherein at least one of the forward and reverse primer includes an AP endonuclease-cleavable linker L, and incubating the reaction mixture under reaction conditions that simultaneously allow the AP endonuclease to cleave at a linker site L and the extension of the primers in a template-specific manner to amplify the target nucleic acid sequence.
    Type: Grant
    Filed: May 10, 2006
    Date of Patent: June 30, 2009
    Assignee: EPoch Biosciences, Inc.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • Publication number: 20080166782
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Application
    Filed: June 28, 2007
    Publication date: July 10, 2008
    Applicant: Epoch Biosciences, Inc.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • Patent number: 7252940
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Grant
    Filed: August 20, 2003
    Date of Patent: August 7, 2007
    Assignee: Epoch Biosciences, Inc.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra
  • Publication number: 20070141586
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Application
    Filed: May 10, 2006
    Publication date: June 21, 2007
    Applicant: Epoch Biosciences, Inc.
    Inventors: Igor Kutyavin, David Milesi, Meri Hoekstra
  • Publication number: 20040101893
    Abstract: The present invention provides a novel method for detection and/or genotyping of nucleic acids that utilizes the specificity of an AP endonuclease. In addition, the present invention provides a novel method for nucleic acid amplification.
    Type: Application
    Filed: August 20, 2003
    Publication date: May 27, 2004
    Applicant: Epoch Biosciences, Inc.
    Inventors: Igor V. Kutyavin, David Milesi, Merl F. Hoekstra