Abstract: The present invention relates to compounds of formula (I) as GPR65 modulators for the treatment of a proliferative disorder, such as e.g. cancer, an immune disorder, asthma, chronic obstructive pulmonary disease (CORD) or acute respiratory distress syndrome (ARDS). Preferred compounds are e.g. N-(Pyridin-2-yl)-6,7,8,9-tetrahydro-5H-5,8-epiminocyclohepta[c]pyridine-10-carboxamide derivatives and similar compounds, such as e.g.

Abstract: Provided is a novel beam delivery system comprising an optical beam spatial period converter. The converter comprises a substrate comprising two or more flexures coupled in series; a plurality of first spacing reflective elements and a plurality of second spacing reflective elements disposed on surface of the substrate. Each first spacing reflective element is configured to receive a respective incoming beam of an incoming array of beams and redirect the respective incoming beam to provide an intermediate beam to a respective second spacing reflective element. Each second spacing reflective element is configured to receive a respective intermediate beam and redirect the respective intermediate beam to provide a respective outgoing beam. The respective outgoing beam is one of plurality of outgoing beams that form an outgoing array of beams. The outgoing array of beams and the incoming array of beams have a different spatial frequencies.

Abstract: A pump is provided, comprising: a base with a first side having a first inlet, a second side having a second inlet and a first outlet, a third side having a second outlet, and a fourth side, wherein the inlets are coupled to a pump motor assembly configured to deliver water from the inlets to a discharge cover, and wherein the outlets are coupled to a sensor pipe configured to deliver water from the discharge cover to the outlets; and a cover with first and second priming ports and an interface on the front, and configured to mount to a housing in a first orientation wherein the front is adjacent the second side and the first priming port is aligned with the discharge cover, and a second orientation wherein the front is adjacent the fourth side and the second priming port is aligned with the discharge cover.

Abstract: A semiconductor switch comprising a first main terminal, a second main terminal, and a control terminal, the semiconductor switch comprising: a high voltage HEMT, the high voltage HEMT comprising a high voltage HEMT source terminal, a high voltage HEMT drain terminal, and a high voltage HEMT gate terminal; a control circuit; and a high voltage transistor device, the high voltage transistor device comprising a transistor device first terminal, a transistor device second terminal, and a transistor device gate terminal; wherein the high voltage HEMT source terminal and the transistor device first terminal are operatively connected to the first main terminal; wherein the high voltage HEMT drain terminal and the transistor device second terminal are operatively connected to the second main terminal; and wherein the high voltage HEMT gate terminal and the transistor device gate terminal are operatively connected to the control terminal via the control circuit.

Abstract: An air-handling system for a heating, ventilation, and air conditioning system comprises a main housing, one or more selectively positionable doors, and a control mechanism. At least one of the doors is disposed in a mixing and conditioning section of the main housing to control a temperature of a flow of air to a delivery section of the main housing. Additionally, at least one of the doors is disposed in the delivery section of the main housing to control a flow of conditioned air through a plurality of conduits. The control mechanism includes one or more cam gears configured to selectively control each of the doors to provide temperature control for various modes of operation of the air-handling system. One of the cam gears includes a cam track having one or more radially inward and/or radially outward segments to mitigate mechanical hysteresis of the doors.

Abstract: The present disclosure provides chromatography columns and methods of chromatographic separation using the same. In particular, the disclosure provides modified columns where the cross-sectional area of the column increases in an area near the end of the column in a flared manner. The modified columns can be used in Expanded Bed Absorption (EBA) systems.

Abstract: An assembly and method for using weather sensors with enhanced modular capability is disclosed. The weather sensor assembly generally comprises a cap module, middle module, and a base module, where the cap module, middle module(s) and the base module are stacked adjacently to provide environmental sealing, weather sensing, and electrical connectivity to the weather sensor assembly. One or more ring mechanisms may be included that interlock the cap module, middle module(s), base module to form the weather sensor assembly into an integrated unit. Moreover, the ring mechanisms enable further modules to be added to the weather sensor assembly for additional capabilities. By doing so, each of the modules in the weather sensor assembly may be independent units that can be removed, reordered, swapped, and added for desired sensing modalities and environments.

Abstract: A cutting guide for a robotic surgical system can include a cutting block defining a guide surface to guide a cutting instrument along a trajectory, an arm connected to the cutting block to couple the cutting guide to the robotic surgical system, and a first retractable shield configured to extend from a first retracted position clear of the trajectory to a second deployed position within the trajectory.

Abstract: A RF power generation system includes a power source configured to generate a periodic waveform applied to a load and a controller configured to receive at least one of a voltage signal or a current signal indicating a respective voltage and current applied to an electrode of the load. The controller determines a surface potential of a workpiece in the load in accordance with the at least one of the voltage signal or the current signal and a series capacitance of the electrode. The controller further determines an ion potential in accordance with an approximation of the surface potential. The periodic waveform may be one of a pulsed DC waveform, a RF waveform, or a pulsed RF waveform.

Abstract: An integrated glucose monitoring system comprising a glucometer and mobile device housed in a housing. The glucometer includes a measurement component to receive a blood glucose test strip containing a sample of blood of an individual, and a port to transmit the blood glucose measurement to a mobile device. The mobile device communicatively and physically coupled to the glucometer. The mobile device includes a port configured to couple with the glucometer, a communication component to receive the blood glucose measurement from glucometer, a power management component to transmit power to the glucometer, and another port to receive power from a power source to power the mobile device. The housing is to house the glucometer and the mobile device to form a single solitary glucose monitoring system.

Abstract: A Honeybee Swarm Trap to provide an inexpensive but sturdy bee box for keeping bees that is flexible in its application. To propagate beehives a beekeeper commonly uses a swarm catcher. These swarm catchers are placed near existing beehives, typically those naturally occurring, a swarm trap may be placed near the location of original beehive. Scout bees can visit the swarm trap and assess the trap for a swarm or propagated swarm to take up residence. Once the honeybee swarm take up residence in the swarm trap, the beekeeper can move the swarm to another location to house the honeybee colony.

Abstract: A hand-held power tool is configured to receive an input indicative of a clutch setting for an electronic clutch from the tool operator, where the clutch setting is selectable from a drill mode, an automated drive mode and one or more user-defined drive modes. Each of the user-defined drive modes specifies a different value of torque at which to interrupt transmission of torque to the output spindle. In an automated drive mode, the controller interrupt torque to the output spindle in an automated manner when a fastener being driven reaches a desired stopping position. In a selected one of the user-defined drive modes, the controller sets a value of a maximum current threshold in accordance with the selected one of the user-defined drive modes and interrupts torque to the output spindle when current measures exceeding the maximum current threshold.

Abstract: A system for planning a mission for spacecraft flying in formation includes an input for receiving data representing a sequence of spatial configurations of the number of spacecraft and a retargeting module configured to generate instructions for causing the number of spacecraft to transition between spatial configurations of the sequence of spatial configurations, including determining a trajectory with periods of fuel-free motion and periods of actuated motion according to a fuel limitation constraint for at least one spacecraft of the number of spacecraft.

Abstract: A system including an external device configured to communicate with an implantable medical device implanted within a patient's body using a communication unit and the implantable medical device is described. The external device further includes a processor, at least one proximity sensor and at least one motion sensor, which is configured to detect whether the external device moves and to provide a respective motion signal, wherein the external device is movable with regard to the patient's body to find and establish a communication connection of the communication unit and the implantable medical device, wherein the communication unit, the at least one proximity sensor and the at least one motion sensor are electrically connected to the processor.

Abstract: A cutting guide for a robotic surgical system can include a cutting block defining a guide surface to guide a cutting instrument along a trajectory, an arm connected to the cutting block to couple the cutting guide to the robotic surgical system, and a first retractable shield configured to extend from a first retracted position clear of the trajectory to a second deployed position within the trajectory.

Abstract: A system and method for visualizing blood flow are disclosed. The method generally includes obtaining a laser speckle contrast imaging (LSCI) image of blood flow; obtaining a white light image of a tissue, the white light image capturing an anatomical structure of a subject in a region associated with the LSCI image of the blood flow; spatially registering the LSCI image and the white light image with one another; overlaying the spatially registered LSCI and white light images; and generating display data which includes the spatially registered LSCI and white light images and that continuously depicts the blood flow overlaying the tissue.

Abstract: A method of imaging a tissue region may comprise visualizing one or more lesions in vivo over a tissue region within a body through an imaging catheter. The method may further comprise measuring a temperature or an electrical potential of the one or more lesions. The method may further comprise overlaying a gradient indicative of the temperature or the electrical potential upon a visual image of the one or more lesions captured in vivo. The method may further comprise registering ablation parameters to the visual image of the one or more lesions and displaying the visual image with the overlaid gradient and the registered ablation parameters.

Abstract: The present invention relates to compounds of formula (Ia), or a pharmaceutically acceptable salt or solvate thereof, (Ia) wherein: ring A is a 5- or 6-membered monocyclic aromatic or heteroaromatic ring, or a 9- or 10-membered bicyclic aromatic or heteroaromatic ring, each of which is optionally substituted with one or more substituents selected from F, Cl, Br, I, CN, alkoxy, NR11R11?, OH, SO2-alkyl, CO2-alkyl, alkyl, haloalkyl, aralkyl, aryl, and heteroaryl, and wherein said aryl and heteroaryl substituents are in turn optionally substituted with one or more substituents each independently selected from F, Cl, Br, I, CN, alkoxy, NR11R11?, OH, alkyl, haloalkyl, and aralkyl; ring B is a monocyclic or bicyclic heteroaromatic group containing at least one nitrogen atom, which is optionally substituted by one or more substituents selected from halo, CN, alkyl, alkoxy, haloalkyl, haloalkoxy, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, CO2-alkyl, O-aryl, NR11R11?, CONR16R17 and SO2NR16R17; Y and Z are each ind

Abstract: Implantable medical device configured to provide for an intra-cardiac pacing includes an electrode arrangement configured to sense a cardiac sense signal and processing circuitry operatively connected to the electrode arrangement. The processing circuitry is configured to start a first timer based on a ventricular sense event; to open an atrial detection window based on a first timer count; to start a second timer based on an atrial sense event; to identify a first timeout based on a comparison of a second timer count and a first pacing delay; to identify a second timeout based on a comparison of the first timer count and a second pacing delay; to identify a third timeout based on a comparison of the first timer count and a basic rate interval; and to trigger a ventricular pace signal based on an identification of at least one of the first, second and third timeouts.

Abstract: Cardiac pacemaker for a patient's heart including a processing unit with a data memory, further including a first detector, and a second detector, a pacing signal generator, which are all electrically connected to the processing unit, wherein the first detector is configured to detect time-dependent electrical signals of the heart, wherein the second detector is configured to detect time-dependent bodily signals of the patient different from the signals detected by the first detector, wherein the first detector and the second detector are configured to transmit the detected and, if applicable, pre-processed signals to the processing unit, wherein the processing unit is configured to process the signals received from the first detector and the signals from the second detector and to detect from the received signals of the first detector intrinsic atrial events, intrinsic ventricular events and pacing events and to determine an actual cardiac rate.