Abstract: Cardiac pacemaker for a patient's heart including a processing unit with a data memory, further including a first detector, and a second detector, a pacing signal generator, which are all electrically connected to the processing unit, wherein the first detector is configured to detect time-dependent electrical signals of the heart, wherein the second detector is configured to detect time-dependent bodily signals of the patient different from the signals detected by the first detector, wherein the first detector and the second detector are configured to transmit the detected and, if applicable, pre-processed signals to the processing unit, wherein the processing unit is configured to process the signals received from the first detector and the signals from the second detector and to detect from the received signals of the first detector intrinsic atrial events, intrinsic ventricular events and pacing events and to determine an actual cardiac rate.

Abstract: An implantable medical device, for example an implantable leadless pacemaker, is disclosed comprising a processor, a therapy signal generator, for example a pacing signal generator, as well as a communication unit and a memory unit, wherein the memory unit is configured to exchange data with the processor, wherein the memory unit comprises a ROM sub-unit, a second memory sub-unit and a state element, wherein the state element is configured to be set to one state of a first state and at least one second state, wherein the second memory sub-unit comprises a RAM, wherein the communication unit is configured to receive information comprising a state input information from an external computing device and to transmit at least one data corresponding to this information to the processor, wherein the processor is configured to set the state of the state element.

Abstract: A cardiac pacemaker for a patient's heart, for example an ILP which realizes integrated circuit space conservation and simple design that covers many modes of operation even though robust behaviour requires complex dynamic adaptive algorithms. The pacemaker includes a processing unit, a detector and a pacing signal generator, wherein the processing unit, the detector and the pacing signal generator are electrically interconnected, wherein the detector is configured to detect electrical signals of the heart, for example an intracardiac electrogram, and to transmit these signals to the processing unit, wherein the processing unit is configured to perceive an intrinsic ventricular signal and an intrinsic atrial signal from the signals received from the detector, to enable or disable the perception of the intrinsic atrial signal, to produce a ventricular pacing control signal.

Abstract: Various embodiments of the present disclosure relate generally to systems and methods for generating multi-view interactive digital media representations in a virtual reality environment. According to particular embodiments, a plurality of images is fused into a first content model and a first context model, both of which include multi-view interactive digital media representations of objects. Next, a virtual reality environment is generated using the first content model and the first context model. The virtual reality environment includes a first layer and a second layer. The user can navigate through and within the virtual reality environment to switch between multiple viewpoints of the content model via corresponding physical movements. The first layer includes the first content model and the second layer includes a second content model and wherein selection of the first layer provides access to the second layer with the second content model.

Abstract: Methods, systems and devices for aligning measurement data sets from different devices. In one embodiment, a synchronization platform includes circuitry configured to establish a first communication link with a first device being worn at a first location on a body of a user, receive a first set of measurement data from a first sensor of the first device indicative of physiological measurements of the user. The circuitry is further configured to: establish a second communication link with the second device, receive a second set of measurement data of the first type from a second sensor of the second device indicative of the physiological measurements of the user, and align the second set of measurement data with the first set of measurement data, wherein the second set of measurement data is a continuation of the first set of measurement data.

Abstract: A hand-held power tool is configured to receive an input indicative of a clutch setting for an electronic clutch from the tool operator, where the clutch setting is selectable from a drill mode, an automated drive mode and one or more user-defined drive modes. Each of the user-defined drive modes specifies a different value of torque at which to interrupt transmission of torque to the output spindle. In an automated drive mode, the controller interrupt torque to the output spindle in an automated manner when a fastener being driven reaches a desired stopping position. In a selected one of the user-defined drive modes, the controller sets a value of a maximum current threshold in accordance with the selected one of the user-defined drive modes and interrupts torque to the output spindle when current measures exceeding the maximum current threshold.

Abstract: An air launch apparatus includes a frame, a grip, and a plurality of sidewalls and also includes a hollow substantially cylindrical barrel having a central longitudinal axis. The air launch apparatus further includes a piston disposed substantially concentric with the barrel. The piston is configured to move longitudinally along the outer surface of the barrel in directions parallel to the longitudinal axis. The air launch apparatus also includes a nut that is configured to engage the piston as a front block carrying the nut is drawn rearward toward a user, and to hold the piston stationary relative to the front block while so engaged. A plunger, fixedly connected to the piston, is configured to move with the piston. Movement of the piston and plunger, forward during cocking draws air into a volume within an air chamber of the air launch apparatus. The plunger, together with the piston, is driven rearward (toward the user) during firing of the air launch apparatus.

Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 is a non-aromatic heterocyclic group comprising at least one ring nitrogen atom, wherein R1 is attached to the sulfur atom of the sulfonylurea group by a ring carbon atom, and wherein R1 may optionally be substituted; and R2 is a cyclic group substituted at the ?-position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: The present invention relates to sulfonylureas and sulfonylthioureas comprising a 5-membered heteroaryl group substituted with a monovalent heteroaryl-containing group. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: A manufacture, matter of compositions, function, methods and uses of a compression legging system that combines a swelling monitor, a patient activity monitor, medical compression legging material, and a mobile application to help PTS patients detect recurrent DVT and seek medical attention quickly before the development of PE, while reducing swelling and preventing DVT via compression therapy.

Abstract: An optical coherence tomography imaging system is disclosed, including: a light source to generate a radiation beam; a pair of photodetectors to acquire data of the radiation beam; a coupler to direct portions of the beam to a sample arm and a reference arm, the coupler to combine light from the sample arm and the reference arm, the combined light to be split into portions to be detected by the pair of photodetectors; and a processor to measure and compare noise profiles of the data and to generate an image using the data, and the noise profile comparison.

Abstract: The present invention relates to phenylsulfonylureas and phenylsulfonylthioureas, wherein the phenyl ring is substituted with a monovalent group comprising either (i) an aryl or a heteroaryl group, or (ii) a nitrogen-containing heterocyclic group, and wherein the group attached to the terminal nitrogen atom of the urea group is a 6-membered cyclic group substituted at the 2- and 4-positions. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

Abstract: A medical manipulation assembly comprises a sheath steerable in response to rotational movement of a sheath steering mechanism. The assembly also comprises a catheter extendable through the sheath. The catheter is steerable in response to rotational movement of a catheter steering mechanism. The sheath and catheter are independently steerable. The assembly also comprises a set of control wires. At least one of the sheath or the catheter includes a plurality of lumens with at least two of the plurality of lumens each sized for passage of one of the control wires of the set of control wires. The steerable catheter includes a working channel sized to receive a visualization instrument therethrough.

Abstract: The present invention relates to compounds of formula (I): wherein Q is selected from O or S; R1 and R3 are each independently hydrogen or an optionally substituted hydrocarbyl group, or R1 and R3 together with the nitrogen atom to which they are attached may form a 3- to 12-membered optionally substituted cyclic group; and R2 is a cyclic group substituted at the position, wherein R2 may optionally be further substituted. The present invention further relates to salts, solvates and prodrugs of such compounds, to pharmaceutical compositions comprising such compounds, and to the use of such compounds in the treatment and prevention of medical disorders and diseases, most especially by the inhibition of NLRP3.

Abstract: The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1 and R2 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Abstract: In some implementations, a weather sensing device may include an optical sensor having an optical transmitter and an optical receiver disposed within a housing to sense atmospheric visibility. In addition, the device may include a first plate disposed on the housing in front of the optical transmitter and having a first aperture. The device may include a second plate disposed on the housing in front of the optical receiver and having a second aperture, where the first plate and second plate are arranged such that one of the plates is mounted on the housing above the other one of the plates edgewise in a vertical dimension. Moreover, the device may include a three dimensional corrugated structure disposed between the first and second apertures to reduce or eliminate optical coupling between the optical transmitter and the optical receiver.

Abstract: An optical system includes an optical mode filter comprising a metasurface optical element. The metasurface optical element is configured to, in response to an optical beam being incident thereon, emit a selected mode beam with first propagation characteristics and one or more unselected mode beams with respective second propagation characteristic. The first propagation characteristics differ from the respective second propagation characteristics such that a majority of the optical power of the selected mode beam is caused to be incident on at least one of a downstream optical element or a target location and a majority of the optical power of the one or more unselected mode beams is caused to be not incident on the at least one of the downstream optical element or the target location.