Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

Abstract: An eye muscle trainer has an outer casing, a control circuit module, a first light emitting unit set, two second light emitting unit sets, two third light emitting unit sets and an eye frame. The outer casing is opaque and has a rear opening. The light emitting unit sets are mounted on the control circuit module. The first light emitting unit set is for focusing user's vision. The second light emitting unit sets are for focusing user's vision on seeing straightly. The third light emitting units are for focusing the user's vision on seeing outwardly. The eye frame accommodates the rear opening of the outer casing. Therefore, wearing the eye muscle trainer releases eyestrain because watching the light emitting unit sets arranged at different position exercises the user's eyes. Consequently, appropriate releasing eyestrain assists improving eyesight.

Abstract: An eye muscle trainer has an outer casing, a control circuit module, a first light emitting unit set, two second light emitting unit sets, two third light emitting unit sets and an eye frame. The outer casing is opaque and has a rear opening. The light emitting unit sets are mounted on the control circuit module. The first light emitting unit set is for focusing user's vision. The second light emitting unit sets are for focusing user's vision on seeing straightly. The third light emitting units are for focusing the user's vision on seeing outwardly. The eye frame accommodates the rear opening of the outer casing. Therefore, wearing the eye muscle trainer releases eyestrain because watching the light emitting unit sets arranged at different position exercises the user's eyes. Consequently, appropriate releasing eyestrain assists improving eyesight.

Abstract: A vest garment is provided for audio stimulation of a fetus by a birth mother includes a back and a left and a right bodice. The left and right bodice are stitched to the back along the sides and over the shoulders so that arms may be passed through an armhole opening defined by the back and each bodice. One bodice includes an audio speaker pocket strategically positioned over the stomach. The other bodice includes an audio signal source pocket which need not be strategically positioned, but which is arranged so as to counterbalance the weight of the speakers in the speaker pocket. An optional microphone input to the audio source signal pocket is provided as are supplemental headphones for the mother.

Abstract: Eukaryotic RNA polymerase II holoenzymes that contain RNA polymerase II and one or more regulatory SRB proteins are described. These holoenzymes will selectively initiate transcription in vitro when supplemented with general transcription factors such as TATA-binding protein (TBP) and factor a (TFIIE). The SRB proteins act positively and negatively to regulate transcription initiation, at least in part, via functional interactions with RNA polymerase II.

Abstract: A speculum includes manually operated scissor arms with keyed shafts at the ends of each arm adapted to receive speculum jaw or blade members supported on the shaft in a desired, adjustable orientation. The speculum blades include a self-contained fiber optic light source. An optional sleeve with shape memory characteristics may be used in combination with the speculum jaw members.

Abstract: A garment for providing audio stimulation to a fetus by a birth mother includes an apron with a horizontal, center belt affixed thereto, the belt having pouches for appropriately positioning an audio input device and speakers. Additionally, microphone input of the voice of the mother may be provided to enhance fetal stimulation.