Abstract: A dry-fire training system and method that uses multiple types of cues (e.g., visual and audible stimuli) presented to the trainee within a predetermined time, preferably simultaneously. The system includes a control application that communicates with one or more targets, each target having light emitting devices capable of displaying different colors and light sensors. The application commands the targets to display different colors to the trainee, along with playing different sounds. One combination of visual stimuli (e.g., a specific color, like “red”) and audible stimuli (e.g., a specific sound, like a “car horn” or “bell”) is a “trigger condition.” Based on whether the trainee, using either a traditional firearm equipped with a laser-emitting cartridge or a simulated firearm that only emits a laser, “shoots” the target, the system determines with the result is a “valid shoot,” a “miss,” or a “bad shoot.

Abstract: An improved method of deoptimization of nucleic acids, particularly nucleic acids associated with genes and/or open reading frames (ORFs) of a variety of pathogens including viruses, retroviruses, bacteria, fungi, and the like. Nucleic acids may be related to genes and/or ORFs from infectious viruses or other diseases and be associated with the elicitation of a protective response when inserted, using recombinant techniques, into a vector and used in a vaccine composition. The nucleic acid sequence of one or more ORFs may be optimized or deoptimized for use in an improved recombinant vaccine to elicit an immune response against an infectious agent when administered to a subject using a variety of dosing and timing regimens.

Abstract: Various embodiments are provided herein for a system and method for automatic monitoring of pavement condition. In at least some embodiments provided herein, there is provided a method for assessing a condition of a pavement segment, the method comprising: analyzing, using a trained machine learning model, an image of the pavement segment; generating, by the machine learning model, an output comprising one or more identified first pavement distresses in the pavement segment; analyzing accelerometer data associated with the pavement segment; based on the analyzing, determining one or more identified second pavement distresses in the pavement segment; and based on the one or more identified first and second pavement defects, determining pavement condition data associated with the pavement segment.

Abstract: Various embodiments are provided herein for a system and method for redaction of media, transportation of redacted media elements and derived metadata and identification, tracking and/or counting of objects within the media. In at least some embodiments provided herein, there is provided a method for redaction at an edge device, the method comprising analyzing media elements received from a media recording unit, identifying image areas for redaction based on predetermined redaction rules, and redacting the identified image areas. In at least some embodiments, metadata is extracted from the media elements prior to redaction and re-embedded within the redacted media element. In at least some embodiments, metadata is transmitted from the edge device separately from the redacted media element.

Abstract: A device for protecting a smoking apparatus; the device has a jacket constructed of a semirigid and/or shock absorbent material configured receive a glass body of the smoking apparatus and may cover at least 50% of the outer surface of the glass body when on an open state. The jacket further may be configured to protect, at least 80% of the outer surface of the glass body against impacts against the outer surface of the glass body while in the closed state. Additionally, a fastener may be fixed to the jacket, and configured to secure the jacket to the smoking apparatus. The device for protecting the smoking apparatus is useful for providing a reusable covering/jacket for protecting the smoking apparatus against impacts.

Abstract: This document presents a system and method for presenting the invention in 150 words or less.

Abstract: An apparatus is used for determining at least one parameter relating to an elongate member disposed within a vessel. The apparatus includes at least one measurement unit having a light emitting component and a corresponding light receiving component. The light receiving component is positioned apart from the light emitting component such that the elongate member is positionable between the light emitting component and the light receiving component. Additionally, the light emitting component is adapted to emit light towards the light receiving component, and the light receiving component is adapted to generate a signal corresponding to the light received from the light emitting component. A method for determining at least one parameter relating to the elongate member disposed within the vessel is also provided.

Abstract: The application discloses non-naturally occurring barley plants with increased resistance to herbicides, particularly imidazolinone herbicides. Also disclosed are the barley seeds per se, an isolated nucleic acid incorporating the nucleic acid sequence conferring imidazolinone resistance, a method of inhibiting weed growth in the vicinity of a barley plant, an a method of growing a barley crop. Seeds have been deposited at NCIMB.

Abstract: The application discloses non-naturally occurring barley plants with increased resistance to herbicides, particularly imidazolinone herbicides. The imidazolinone resistance is conferred by mutant acetohydroxy acid synthase (AHAS), more particularly by AHAS with a SER653 mutation. Also disclosed are the barley seeds per se, an isolated nucleic acid incorporating the nucleic acid sequence conferring imidazolinone resistance, a method of inhibiting weed growth in the vicinity of a barley plant, an a method of growing a barley crop. Seeds have been deposited at NCIMB.

Abstract: An apparatus is used for determining at least one parameter relating to an elongate member disposed within a vessel. The apparatus includes at least one measurement unit having a light emitting component and a corresponding light receiving component. The light receiving component is positioned apart from the light emitting component such that the elongate member is positionable between the light emitting component and the light receiving component. Additionally, the light emitting component is adapted to emit light towards the light receiving component, and the light receiving component is adapted to generate a signal corresponding to the light received from the light emitting component. A method for determining at least one parameter relating to the elongate member disposed within the vessel is also provided.

Abstract: The application discloses non-naturally occurring barley plants with increased resistance to herbicides, particularly imidazolinone herbicides. Also disclosed are the barley seeds per se, an isolated nucleic acid incorporating the nucleic acid sequence conferring imidazolinone resistance, a method of inhibiting weed growth in the vicinity of a barley plant, an a method of growing a barley crop. Seeds have been deposited at NCIMB.

Abstract: Chemical processes and intermediates useful in the manufacture of the quinazoline derivative 4-(3?-chloro-4?-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline, in particular processes for the manufacture of 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one of Formula II and 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile of Formula III and their use in the manufacture of the quinazoline derivative.

Abstract: Oligonucleotide comprising at least one internucleotide phosphorus atom protected with a group of formula —XaSiR3R4R5 provided. Xa represent 0 or S, and R3, R4 and R5 each independently are optionally substituted hydrocarbyl groups, selected such that that total number of carbon atoms in R3 plus R4 plus R5 is 4 or more. Process for the preparation of these oligonucleotides, intermediate compounds useful therein, and process for the preparation of the intermediate compounds are also provided.

Abstract: A process for performing nucleophilic substitution reactions on aryl diazonium salts or derivatives thereof wherein the aryl diazonium salt is first generated in an aqueous solvent system followed by partitioning of the aryl diazonium salt with a hydrophobic ionic liquid thereby allowing subsequent reaction of the aryl diazonium salt with an appropriate nucleophilic species in the hydrophobic ionic liquid to the desired product without the need to first isolate the aryl diazonium salt.

Abstract: A process for the preparation of an oligonucleotide is provided. The process comprises the assembly of an oligonucleotide attached to a solid support, wherein the solid support is prepared by a process comprising polymerisation of a monomer which comprises a protected hydroxypolyC2-4 alkyleneoxy chain attached to a polymerisable unit wherein the protected hydroxypolyC2-4 alkyleneoxy chain contains from 2 to 10 C2-4 alkyleneoxy groups and wherein the hydroxypolyC2-4 alkyleneoxy chain is protected with an acid-labile protecting group, preferably an optionally substituted trityl group.

Abstract: The invention relates to chemical processes and intermediates useful in the manufacture of the quinazoline derivative 4(3? chloro 4? fluoroanilino)-7-methoxy-6-(3-morpholinopropoxyquinazoline. In particular, the invention relates to processes for the manufacture of 7-methoxy-6-(3-morpholinopropoxy)-3,4-dihydroquinazolin-4-one of Formula (II) and 4-methoxy-5-(3-morpholinopropoxy)-2-nitrobenzonitrile of Formula (III) and their use in the manufacture of said quinazoline derivative.

Abstract: A polymer support is provided which comprises protected hydroxypolyC2-4alkyleneoxy chains attached to a cross-linked polymer wherein the protected hydroxypolyC2-4alkyleneoxy chain contains from 2 to 10 C2-4alkyleneoxy groups and wherein the hydroxypolyC2-4alkyleneoxy chains are protected with an acid labile group. The acid labile protecting group is preferably a poly-aryl methane protecting group. A monomer and process for the preparation of said support are also provided.

Abstract: A testing apparatus and method for characterizing the aerodynamic particle size of an atomized medicament emitted from a metered dose inhaler unit during testing with a particle characterization device in which the testing apparatus includes a first clamp of a first fixture in removable clamping and locking engagement with a throat, which is in fluid communication with a particle characterization device, a second clamp in removable clamping and locking engagement with a delivery device of the metered dose inhaler unit having a canister, containing atomized medicament, operatively loaded therein, an alignment mechanism that removably couples the first fixture to the second fixture at an aligned position therefore causing the throat to be in fluid communication with the delivery device, and an actuation assembly mounted to the first fixture having means that operatively thrusts the canister into the delivery device of the metered dose inhaler unit, thus releasing atomized medicament.

Abstract: This invention is concerned with an improved process for the synthesis of hydroxysulfone, which is a key intermediate in the synthesis of carbonic anhydrase inhibitors, especially dorzolamide. Carbonic anhydrase inhibitors are known to be effective in treating elevated intraocular pressure or glaucoma.

Abstract: A trailer for transporting large machinery such as farm combines and the like. The trailer comprises a main or center portion flanked laterally by side portions, each side portion comprising a plurality of outwardly telescoping sections which form runways to receive the wheels of the machinery. The trailer wheels and towing gear are attached to the main portion. The side sections are extendable to accommodate equipment having a wide wheel-span. Each of the three side sections on each side, can be separately extended or retracted by a single person. An alignment system is provided to facilitate alignment of the three sections. A chain limits the outward extension of the side sections. Locking pins hold the side sections in their inner positions.