Abstract: The present invention is directed to a modified clostridial neurotoxin comprising a botulinum neurotoxin A (BoNT/A) Hcc domain, wherein the Hcc domain comprises a modification of methionine 1144 (MI 144), and wherein the modification increases oxidative resistance of the modified clostridial neurotoxin when compared to an otherwise identical clostridial neurotoxin lacking the modification. Also provided are (inter alia) corresponding methods for producing the same, methods for selecting oxidation resistant clostridial neurotoxins, nucleic acids encoding the same, and therapeutic uses of said modified clostridial neurotoxins.

Abstract: A first authenticator payload is obtained that includes a first authenticator random value. A first authenticator encrypted file is generated with an authenticator public key that is related to a client authenticator application. The first authenticator encrypted file is generated based on a first cryptographic algorithm. The first authenticator encrypted file includes the first authenticator payload. A first target payload is obtained that includes a first target random value. A first target encrypted file is generated with the first authenticator random value. The first target encrypted file is generated based on a second cryptographic algorithm. The first target encrypted file includes the first target payload.

Abstract: Methods and systems for protecting a secured network are presented. For example, one or more packet security gateways may be associated with a security policy management server. At each packet security gateway, a dynamic security policy may be received from the security policy management server, packets associated with a network protected by the packet security gateway may be received, and at least one of multiple packet transformation functions specified by the dynamic security policy may be performed on the packets.

Abstract: An automated clamp for clamping a rib web to a rib post or rib foot of an aircraft wing box is disclosed including a clamp frame having a first arm and a second arm extending from the base of the clamp frame. The second arm is moveable towards and away from the first arm; a robot end effector connector coupled to the clamp frame; clamp jaws including a first jaw fixed at a distal end of the first arm, and a second jaw fixed at a distal end of the second arm, the clamp jaws configured to clamp a rib web to a rib post or clamp a rib web to a rib foot. The first jaw and/or second jaw includes a contact normalisation system, the contact normalisation system including: a jaw body fixed relative to the respective arm.

Abstract: An automated clamp for clamping a rib web to a rib post or rib foot of an aircraft wing box is disclosed including a clamp frame having a first arm and a second arm extending from the base of the clamp frame. The second arm is moveable towards and away from the first arm; a robot end effector connector coupled to the clamp frame; clamp jaws including a first jaw fixed at a distal end of the first arm, and a second jaw fixed at a distal end of the second arm, the clamp jaws configured to clamp an aircraft assembly. One of the jaws includes a tool module docking aperture into which a tool module is insertable for accessing the aircraft assembly; and a swarf channel extending into the tool module docking aperture, the swarf channel fluidically connected to a vacuum source and configured to extract waste material adjacent the aircraft assembly.

Abstract: An automated clamp for clamping a rib web to a rib post or rib foot of an aircraft wing box is disclosed including a clamp frame, a first arm and a second arm extending from the base of the clamp frame, the second arm is moveably mounted to the base of the clamp so as to be moveable towards and away from the first arm; a robot end effector connector coupled to the clamp frame. The clamp jaws include a first jaw fixed at a distal end of the first arm, and a second jaw fixed at a distal end of the second arm, the clamp jaws configured to clamp the rib web to the rib post or rib foot. One of the clamp jaws defines a tool module docking aperture configured to receive a tool module for providing access to the rib web and rib post or rib foot clamped between the clamp jaws.

Abstract: A vertical landing and take-off aircraft VTOL transitions from a vertical takeoff state to a cruise state where the vertical takeoff state uses propellers to generate lift and the cruise state uses wings to generate lift. The aircraft has an M-wing configuration with propellers located on the wingtip nacelles, wing booms, and tail boom. The wing boom and/or the tail boom can include boom control effectors. Hinged control surfaces on the wings, tail boom, and tail tilt during takeoff and landing to yaw the vehicle. The boom control effectors, cruise propellers, stacked propellers, and control surfaces can have different positions during different modes of operation in order to control aircraft movement and mitigate noise generated by the aircraft.

Abstract: A semi-trailer including a cargo area, and an integrated fifth-wheel coupler unit extending horizontally along a front lower portion of the semi-trailer. The coupler unit includes an upper coupler surface defining a floor level of the cargo area, a lower coupler surface spaced below the upper coupler surface, and a kingpin projecting downwardly from the lower coupler surface and configured for coupling with a tow vehicle fifth wheel. A utility line connection portion is provided for establishing connections between at least one utility source of the tow vehicle and at least one utility component of the semi-trailer. The integrated fifth-wheel coupler unit includes a front wall with a recessed cavity at a central widthwise location accommodating the utility line connection portion.

Abstract: The disclosure provides methods for treating a subject in need thereof comprising administering to the subject a therapeutically-effective dose of psilocybin. The methods described herein may be used to treat a variety of diseases, disorders, and conditions. For example, the methods may be used to treat anxiety disorders, eating disorders, and headache disorders.

Abstract: A payor account is monitored to detect when it receives assets sufficient to meet the payor's current obligations under a deal. When this condition is met, assets sufficient to meet the obligation are transferred from the payor account to an intermediary virtual account. Similarly, the intermediary account is monitored for whether it contains sufficient assets to meet an obligation to a payee under the deal. When this condition is met, sufficient assets to meet this obligation are transferred from the intermediary account to the payee account.

Abstract: Sprayable polyurethane compositions, in the form of spray polyurethane foams or low rise adhesives, when spray applied in the area of spray application at any given time, having monomeric MDI contents in the spray application area of no more than 20 parts per billion as measured in accordance with PEL Method 47 and having a viscosity of from 100 to 3,000 cP at 25° C. according to ASTM D2196.

Abstract: Implementations described herein relate to methods, systems, and computer-readable media for automated computer configuration. In some implementations, a method includes providing a configuration tool on a computer. The method further includes accessing a configuration file that includes configuration settings, wherein the configuration file is a plain text file. The method further includes selecting particular settings for the computer from the configuration settings based at least in part on the configuration file and identification information of the computer. The method further includes automatically configuring the computer with particular software that is identified based on the particular settings.

Abstract: The disclosed principles provide novel antennas and corresponding methods of manufacturing thereof. In one aspect, an antenna according to the disclosed principles have a dielectric unit. The dielectric unit may be azimuthally uniform, radially symmetric, or symmetric. The dielectric unit may include a first conducting surface, a second conducting surface, and a non-conducting aperture. The first conducting surface may be located on a first radially interior surface of the dielectric unit and have both convex and concave surfaces. The second conducting surface, oblique to an axis of radial symmetry, may extend radially outward from the axis of radial symmetry. The non-conducting aperture may be located on the radial exterior of the dielectric unit. The first conducting surface and the second conducting surface may define a dielectric volume extending radially toward and terminating in the non-conducting aperture.

Abstract: A semiconductor package includes source clock circuitry to generate a source clock signal. Reference clock circuitry generates a reference clock signal. A first timing circuit includes a first source clock input to receive the source clock signal. First fan-out circuitry distributes the received source clock signal as a first distributed clock signal to a first set of clocked devices. A first delay circuit delays the received source clock signal by a first delay value based on a first phase difference between the first distributed clock signal and the reference clock signal.

Abstract: A build plate assembly for a three-dimensional printer includes: a lighting panel having individually addressable pixels configured to selectively emit light and/or transmit light from illumination below the pixels to a top surface top surface of the lighting panel; a rigid, optically transparent, gas-impermeable planar screen or base having an upper surface having an uneven surface topology and a lower surface that is affixed to the top surface of the lighting panel; and a flexible, optically transparent, gas-permeable sheet having upper and lower surfaces, the upper surface comprising a build surface for forming a three-dimensional object, the sheet lower surface positioned opposite the base, wherein the build plate is configured to permit gas flow to the build surface.

Abstract: The present invention relates to novel ophthalmic devices comprising polymerized compounds comprising a photoactive chromophore, special polymerized compounds, and special monomer compounds being particularly suitable for compositions and ophthalmic devices. The present invention is also directed to a process of changing the optical properties of said ophthalmic device or a precursor article for an ophthalmic device.

Abstract: An implant removal device includes a body, a first arm, a second arm, an actuation interface, and an extraction member. The first arm is supported at the body and configured to move relative to the body between a retracted position and a skin gripping position. The second arm is supported at the body and configured to move relative to the body between the retracted position and the skin gripping position. The actuation interface is supported at the body. The actuation interface is configured to receive a first actuation input thereat to cause at least one of the first arm and the second arm to move from the skin gripping position to the retracted position. The extraction member is supported at the body and located between the first arm and the second arm.

Abstract: The present invention relates to a method for dyeing hair fibres, in particular a method which involves coating hair fibres with a hair dye composition and directing radio frequency electromagnetic radiation to the coated hair fibres to cause heating within the coated hair fibres by dielectric loss. The present invention also relates to kits and appliances for use in connection with the method, as well as the use of radio frequency electromagnetic radiation in reducing the effective dye-treatment time for hair fibres. In one aspect, there is provided a method of dyeing hair fibres, said method comprising the steps of: i) coating one or more hair fibres with a hair dye composition; and ii) directing radio frequency electromagnetic radiation having one or more frequencies from 1 MHz to 300 MHz to the one or more coated hair fibres to cause heating within the one or more coated hair fibres by dielectric loss.

Abstract: An implant removal device includes a body, a first arm, a second arm, an actuation interface, and an extraction member. The first arm is supported at the body and configured to move relative to the body between a retracted position and a skin gripping position. The second arm is supported at the body and configured to move relative to the body between the retracted position and the skin gripping position. The actuation interface is supported at the body. The actuation interface is configured to receive a first actuation input thereat to cause at least one of the first arm and the second arm to move from the skin gripping position to the retracted position. The extraction member is supported at the body and located between the first arm and the second arm.