Patents by Inventor David Morgans

David Morgans has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of an amino-pyrimidine and intermediates thereof
    Patent number: 11142516
    Abstract: Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof. Also provided herein are novel intermediates used in this process and their preparation.
    Type: Grant
    Filed: December 26, 2018
    Date of Patent: October 12, 2021
    Assignee: Cytokinetics, Inc.
    Inventors: Matthew Peterson, Kevin Lu, Bradley Morgan, David Morgans, Tohru Fukuyama
  • PROCESS FOR THE PREPARATION OF AN AMINO-PYRIMIDINE AND INTERMEDIATES THEREOF
    Publication number: 20210061786
    Abstract: Provided herein is a novel process for the preparation of an amino-pyrimidine and salts thereof. Also provided herein are novel intermediates used in this process and their preparation.
    Type: Application
    Filed: December 26, 2018
    Publication date: March 4, 2021
    Applicant: Cytokinetics, Inc.
    Inventors: Matthew PETERSON, Kevin LU, Bradley MORGAN, David MORGANS, Tohru FUKUYAMA
  • Method for identifying modulators of ubiquitin ligases
    Patent number: 9464311
    Abstract: The present invention provides a screen which exploits mechanism-based activity probes that specifically and covalently modify the active site cysteine thiol residue of E3 Ub ligases including, but not limited to the HECT and RBR family. The activity probes are used to screen for activators and inhibitors of E3 Ub ligases, and to interrogate the functional state of E3 Ub ligases in human disease.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: October 11, 2016
    Assignee: E3X Bio, Inc.
    Inventors: Brigit Riley, Jennifer Johnston, David Morgans
  • METHOD FOR IDENTIFYING MODULATORS OF UBIQUITIN LIGASES
    Publication number: 20140327158
    Abstract: The present invention provides a screen which exploits mechanism-based activity probes that specifically and covalently modify the active site cysteine thiol residue of E3 Ub ligases including, but not limited to the HECT and RBR family. The activity probes are used to screen for activators and inhibitors of E3 Ub ligases, and to interrogate the functional state of E3 Ub ligases in human disease.
    Type: Application
    Filed: May 2, 2014
    Publication date: November 6, 2014
    Applicant: E3X BIO
    Inventors: Brigit Riley, Jennifer Johnston, David Morgans
  • Compounds, compositions, and methods
    Publication number: 20080021050
    Abstract: Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed.
    Type: Application
    Filed: March 12, 2007
    Publication date: January 24, 2008
    Inventors: Gustave Bergnes, Whitney Smith, Bing Yao, David Morgans, Andrew McDonald
  • Novel Biphenyl Compounds And Their Use
    Publication number: 20070265345
    Abstract: The invention is directed to certain biphenyl compounds. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and Y are as defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are KSP inhibitors, particularly human KSP inhibitors, and can be useful for the treatment for a variety of diseases and conditions, such as cancer, hyperplasias, restenosis, cardiac hypertrophy, immune disorders, fungal disorders, and inflammation. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting KSP and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Application
    Filed: July 27, 2005
    Publication date: November 15, 2007
    Applicants: SMITHKLINE BEECHAM CORPORATION, CYTOKINETICS
    Inventors: Amita Chaudhari, Dashyant Dhanak, Steven Knight, David Morgans, Cynthia Parrish
  • Compounds, Compositions and Methods
    Publication number: 20070259951
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Application
    Filed: December 17, 2004
    Publication date: November 8, 2007
    Applicants: SMITHKLINE BEECHAM CORPORATION, CYTOKINETICS
    Inventors: Cynthia Parrish, Dashyant Dhanak, Steven Knight, David Morgans
  • Compounds, compositions and methods
    Publication number: 20070254870
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Application
    Filed: April 19, 2007
    Publication date: November 1, 2007
    Inventors: Gustave Bergnes, Dashyant Dhanak, Steven Knight, Pu Lu, David Morgans, Kenneth Newlander
  • Certain chemical entities, compositions and methods
    Publication number: 20070208000
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 13, 2006
    Publication date: September 6, 2007
    Inventors: Bradley Morgan, Pu-Ping Lu, Alex Muci, Erica Kraynack, Todd Tochimoto, David Morgans
  • Certain chemical entities, compositions and methods
    Publication number: 20070197504
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 13, 2006
    Publication date: August 23, 2007
    Inventors: Bradley Morgan, Alex Muci, Erica Kraynack, Todd Tochimoto, Pu-Ping Lu, David Morgans
  • Compounds, compositions and methods
    Publication number: 20070197497
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 14, 2006
    Publication date: August 23, 2007
    Inventors: Bradley Morgan, David Morgans, Alex Muci, Pu-Ping Lu, Erica Kraynack, Todd Tochimoto
  • Certain chemical entities, compositions, and methods
    Publication number: 20070197481
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Application
    Filed: May 6, 2005
    Publication date: August 23, 2007
    Inventors: Xiangping Qian, Andrew McDonald, Han-Jie Zhou, Luke Ashcraft, Bing Yao, Hong Jiang, Jennifer Kuo Chen Huang, Jianchao Wang, David Morgans, Bradley Morgan, Gustave Bergnes, Dashyant Dhanak, Steven Knight, Nicholas Adams, Cynthia Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Certain chemical entities, compositions and methods
    Publication number: 20070197505
    Abstract: Certain substituted urea derivatives modulate diskeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and are useful in the treatment of obesity, sarcopenia, wasting syndrome, frailty, muscle spasm, cachexia, neuromuscular diseases (e.g., amyotrophic lateral sclerosis, spinal muscular atrophy, familial or acquired myopathies or muscular dystrophies), post-surgical and post-traumatic muscle weakness, and other conditions.
    Type: Application
    Filed: December 13, 2006
    Publication date: August 23, 2007
    Inventors: Bradley Morgan, Fady Malik, David Morgans
  • Certain chemical entities, compositions and methods
    Publication number: 20070197507
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 13, 2006
    Publication date: August 23, 2007
    Inventors: Bradley Morgan, Erica Kraynack, Pu-Ping Lu, Alex Muci, David Morgans
  • Certain chemical entities, compositions, and methods
    Publication number: 20070161674
    Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.
    Type: Application
    Filed: November 15, 2006
    Publication date: July 12, 2007
    Inventors: Scott Collibee, Zhe Yang, Luke Ashcraft, Gustave Bergnes, Bradley Morgan, David Morgans, Jianchao Wang
  • Certain chemical entities, compositions, and methods
    Publication number: 20070161683
    Abstract: Compounds useful for treating cellular proliferative diseases are disclosed.
    Type: Application
    Filed: November 14, 2006
    Publication date: July 12, 2007
    Inventors: Scott Collibee, Gustave Bergnes, Matthew Hamilton, Bradley Morgan, David Morgans
  • Certain chemical entities, compositions and methods
    Publication number: 20070161617
    Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
    Type: Application
    Filed: December 14, 2006
    Publication date: July 12, 2007
    Inventors: Bradley Morgan, David Morgans, Alex Muci, Pu-Ping Lu, Erica Kraynack, Todd Tochimoto
  • Certain chemical entities, compositions, and methods
    Publication number: 20070149516
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Application
    Filed: November 8, 2006
    Publication date: June 28, 2007
    Inventors: Xiangping Qian, Luke Ashcraft, Jianchao Wang, Bing Yao, Hong Jiang, Gustave Bergnes, Bradley Morgan, David Morgans, Dashyant Dhanak, Steven Knight, Nicholas Adams, Cynthia Parrish, Kevin Duffy, Duke Fitch, Rosanna Tedesco
  • Certain chemical entities, compositions, and methods
    Publication number: 20070135435
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
    Type: Application
    Filed: November 1, 2006
    Publication date: June 14, 2007
    Inventors: Xiangping Qian, Jianchao Wang, Gustave Bergnes, Bradley Morgan, David Morgans, Martha Sarpong, Dashyant Dhanak, Steven Knight
  • Compounds, methods and compositions
    Publication number: 20070135432
    Abstract: Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
    Type: Application
    Filed: November 15, 2006
    Publication date: June 14, 2007
    Inventors: Han-Jie Zhou, David Morgans, Gustave Bergnes, Steven Knight, Kenneth Newlander, Dashyant Dhanak, Nicholas Adams