Abstract: The present disclosure addresses this need by providing crystalline fine particle forms of PRX-3140 potassium salt, methods for preparation and the treatment for Alzheimer's disease (AD) and other dementias affecting the cholinergic and/or serotonergic systems including post-traumatic stress disorder (PTSD). In certain aspects, the present disclosure provides novel methods of preparing the compound of Formula I thereof, or PRX-3140 potassium salts, crystalline fine particle forms of PRX-3140 potassium salt, and compositions comprising them. In certain aspects, the present disclosure provides novel crystalline fine particle form of PRX-3140 potassium salt which may provide advantages including improved bioavailability and stability relative to other crystalline or amorphous forms. In other aspects, the present disclosure provides oral dosage forms of crystalline fine particle form of PRX-3140 potassium salt and excipients with improved stability.

Abstract: A liquid dispensing apparatus includes a container including a downwardly extending wall portion that defines a bottom opening through which a liquid in the container is dispensed; a valve; and an actuator connected to the valve for controlling dispensing of the fluid from the container. The actuator is movable along an axis between a dispensing position, in which liquid from the container is dispensed, the valve being open when the actuator is in the dispensing position; and a non-dispensing position, in which liquid from the container is not dispensed, the valve being closed when the actuator is in the non-dispensing position, and the actuator in the non-dispensing position being located further from the container than when in the dispensing position. A spring biases the actuator in a direction away from the container. The liquid may be dispensed into a bottle containing a hard seltzer for flavoring of the seltzer.

Abstract: Systems for providing on-demand cup dispensing for food service are provided herein. A system includes a food request module configured to receive a request for food service for a customer. The system further includes a cup source configured to hold one or more cups. The system further includes a cup printer configured to print at least one of order information or personalization information based on the food service on a sidewall of a first cup. The system further includes a cup filler configured to fill the printed first cup with a consumable based on the food service. The system further includes a cup closer configured to at least partially close the open end of the filled first cup. The system further includes one or more cup transfer elements for transferring the first cup between the cup printer, the cup filler, and the cup closer.

Abstract: A biometric attribution approach identifies a keyboard actor based on timing between entered keystrokes. Patterns tend to emerge in a timing interval between keystrokes entered by an actor. The keystroke patterns of an actor are analyzed to compute a signature exhibited by the actor. Gathered or intercepted keystroke patterns of an unknown actor are compared to identify a likelihood that typing sessions emanated from a common actor. Keystroke activity of a purported suspect actor can be compared to a database or model of keystroke attributes for determining if the keystroke activity emanated from the same actor as other keystroke sequences. Keystroke patterns rely only on the timing between keystrokes, as key data and upstroke information need not be gathered since the comparisons reply only on keystroke timing deltas.

Abstract: Methods, systems, and devices for frequency regulation for memory management commands are described. A memory device may maintain a respective first counter and second counter for each monitoring area of the memory device, where the counters may be incremented for each activate command received for the corresponding monitoring area. If the first counter satisfies a first threshold, an activate command issued to the monitoring area may be ignored. If the second counter fails to satisfy a second threshold, a memory management command issued to the monitoring area may be ignored and the memory device may maintain a value of the second counter, while decrementing the first counter. Alternatively, if the second counter satisfies the second threshold, the memory device may perform a memory management operation associated with a received memory management command and may decrement the first counter and the second counter.

Abstract: Suture buttons are disclosed for fixing two bones together. The suture buttons may enable surgeons to more easily and effectively implement the suture button technique, such as to repair syndesmosis injuries in ankles. A first suture button includes a pulley peg extending from a button head. The pulley peg may be positioned with a bone hole upon installation of the first suture button, which may help protect suture and help reduce potential patient discomfort. The second suture button helps facilitate the second suture button flipping into place upon deployment from a button inserter. Each of the first and second provided suture buttons may help reduce friction between the respective buttons and suture during an installation procedure. The first and second provided suture buttons may be used together in a surgical procedure or individually with other suitable buttons or anchors.

Abstract: A container has a product in a product-receiving area and has a sealing area surrounding the product-receiving area. A length of film is arranged over the container. A space above the film is evacuated using an evacuating portion of an upper sealing module arranged over the film, so as to cause a portion of the film to conform to the upper sealing module. An area of the film is cut out by moving a cutting tool relative to the upper sealing module from a recessed position to a cutting position. The cut-out area of film includes the portion of the film conformed to the upper sealing module, is brought into contact with the sealing area of the container by moving the upper sealing module relative to the container, and is sealed to the sealing area of the container using a heat sealing portion of the upper sealing module.

Abstract: Methods, systems, and devices for techniques for non-volatile data protection are described. As part of a power on operation, a non-volatile memory system may be configured to selectively stored data. For example, the memory system may determine whether a host system is authorized to access data stored in the memory system prior to a power off operation. If the memory system determines that the host system is authorized, the memory device may retain the data. If the memory system determines that the host system is not authorized, the memory system may erase all or a portion of the data. In some cases, the memory system may maintain a retain flag to determine whether the host system is authorized. Additionally or alternatively, the memory system may determine whether a password received from the host system is valid to determine whether the host system is authorized.

Abstract: Systems, methods and apparatuses to log memory errors in memory devices that can perform wear leveling based on physical addresses used in the memory devices to address select memory cells. For example, a controller of a memory sub-system communicates with a memory device installed in the memory sub-system to access memory cells in the memory device. During the communication to access memory cells in the memory device, the controller can determine a memory error at a first address. If the controller transmits the first address to the memory device for memory access at the time of the memory error, the memory device converts the first address to a second address to perform the memory access. The controller can be configured to determine the second address and record, in an error log, the memory error in association with the second address.

Abstract: The disclosure relates to a machine for thermal treatment of bulk material, comprising, a stationary furnace which presents a support structure, and a plurality of pallet cars traveling through the furnace, said plurality of pallet cars together defining, at a lateral side thereof, a common engagement surface which extends through the furnace, wherein a gap is defined between the support structure of the furnace and the common engagement surface, said gap having a gap length, the machine further comprising: a sealing system comprising: one or more drop bars, wherein each drop bar of the one or more drop bars includes a brush arranged on the drop bar such that the brush is configured to be in engagement with the common engagement surface such that the one or more drop bars covers the gap over at least parts of the gap length.

Abstract: Systems and methods to track an object within an operating room with a camera unit. The camera unit includes a first optical sensor with sensing elements to sense light in a near-infrared spectrum and a second optical sensor to sense light in a visible light spectrum. A controller is in communication with the first and second optical sensors. The controller obtains, from the second optical sensor, data related to the object within the operating room. The controller modifies control of the sensing elements of the first optical sensor based on the data of the object obtained by the second optical sensor.

Abstract: A feature engineering engine is included in an analytics application provided to at least one subscriber from a plurality of subscribers. The feature engineering engine generates a reduced discovery dataset based on an input dataset and stores at least a portion of the reduced discovery dataset in cache memory associated with the analytics application. While displaying at least a portion of the reduced discovery dataset, the feature engineering engine performs one or more entity resolution operations and generates an instantiated set of features. In some embodiments, the instantiated set of features is generated based on a previously generated, reusable feature definition. In some embodiments, using the instantiated set of features, a trained machine learning model is automatically selected from a plurality of models based on a performance metric determined for the instantiated set of features.

Abstract: A document object may be transmitted to a plurality of user devices. The document object may include at least one field for display of a content object of a group of content objects. The field may be associated with an identifier corresponding to the group of content objects. When the document object is accessed, then the access may trigger a request to a server, which may select a content object of the group of content objects using a content object identification function. The content object identification function may be dynamically updated based at least in part on the document object being accessed by one or more of the plurality of user devices. Responsive to the request, a unique content object identifier corresponding to the selected content object may be transmitted to the user device and displayed at the accessed document object.

Abstract: Systems that include blister packs and methods of use thereof are disclosed. In various embodiments, a system includes a blister pack having at least one blister comprising a base and a top layer. The blister contains a liquid reagent. The system further includes an actuator configured to release the liquid reagent from the blister. The system further includes a substrate configured to hold a tissue sample and receive the liquid reagent from the blister upon release.

Abstract: An apparatus and method for electrochemically depositing a unitary layer structure using a reactor configured to contain an electrolyte solution with an anode array containing a plurality of independently electrically controllable anodes arranged in a two-dimensional array, a cathode, an addressing circuit configured to receive a signal containing anode address data and configured to output a signal causing an anode array pattern; and a first controller being a current controller configured to control a flow of current to the anode array; a second controller in communication with the addressing circuit, the current controller and the anode array, the second controller operable to communicate with the current controller to command the flow of current to each anode in the anode array causing an electrochemical reaction at the cathode to deposit a layer corresponding to the anode array pattern signal received from the addressing circuit; and a third controller configured to clear bubbles which have formed on the

Abstract: Systems for providing on-demand cup printing and dispensing for food service are provided herein. A cup dispenser includes a cup source configured to hold a stack of cups and one or more cup-moving elements configured to cause a cup from the stack of cups to move through the cup dispenser. The cup dispenser includes a motor configured to operate the one or more cup-moving elements to cause the cup to move through the cup dispenser along a path. The cup dispenser also includes a printer configured to print at least one of order information or personalization information on the cup that is based on the food service order associated with the cup. The cup dispenser further includes a dispensing section that provides the cup, which includes the at least one of order information or personalization information printed thereon.

Abstract: Flowcell devices configured for reversible assembly, and methods of assembly, disassembly, and use thereof are provided. The methods and devices allow the interior of the flowcell device to be accessed without damaging, or otherwise disturbing sensitive samples and surfaces.

Abstract: Approaches described herein allow an appliance to receive a message from a client device when the client device is attempting to connect to a service other than the appliance. For instance, a client device might connect to a service on a private network, however if the client device is not on the private network, it may encounter an appliance such as a gateway. The appliance is configured to return a message to a client device indicating that it is an appliance, and the client device returns a certificate to the appliance that allows the client to indicate a first purpose of a connection and a second purpose of the connection. In approaches described herein, the second purpose is used by the appliance to perform an action related to providing the service with a certificate that allows for the first purpose, which can include information to create a secure connection between the service and the client device.

Abstract: Suture buttons are disclosed for fixing two bones together. The suture buttons may enable surgeons to more easily and effectively implement the suture button technique, such as to repair syndesmosis injuries in ankles. A first suture button includes a pulley peg extending from a button head. The pulley peg may be positioned with a bone hole upon installation of the first suture button, which may help protect suture and help reduce potential patient discomfort. The second suture button helps facilitate the second suture button flipping into place upon deployment from a button inserter. Each of the first and second provided suture buttons may help reduce friction between the respective buttons and suture during an installation procedure. The first and second provided suture buttons may be used together in a surgical procedure or individually with other suitable buttons or anchors.

Abstract: Devices (e.g., flow cell holders) and methods for flow cell assembly and disassembly are provided. The flow cell holders and methods can be used to join or separate the bottom and top layers of a flow cell.