Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.

Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.

Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.

Abstract: Powder formulations for inhalation which comprise microparticles containing an antibiotic and magnesium stearate are useful for the treatment of bacterial infections associated with certain pulmonary diseases.

Abstract: The present disclosure relates to processing operations that enable use of cache memory for content validation and error remediation of content. Functionality of the cache is extended to enable interfacing between a cache and a validation component, which is configured to validate data read directly from the cache. Corrupted content may be updated and propagated to a permanent data store associated with an application/service, system, etc. Use of the cache may be optimal for targeting recent and/or heavily accessed content as well as a means for offloading data processing operations from a permanent data storage. Examples described herein extend to those in which data associated with an electronic file is already stored in cache memory as well as those in which update occurs directly to a permanent data storage and subsequently forwarded for validation processing.

Abstract: The present disclosure relates generally to binder powders for use in powder material processing and processes for their preparation. The disclosure further relates to binder powders for use in making solid powder compact forms, solid powder compact forms containing said binder powders and methods for making solid powder compact forms.

Abstract: The present disclosure relates to processing operations that enable use of cache memory for content validation and error remediation of content. Functionality of the cache is extended to enable interfacing between a cache and a validation component, which is configured to validate data read directly from the cache. Corrupted content may be updated and propagated to a permanent data store associated with an application/service, system, etc. Use of the cache may be optimal for targeting recent and/or heavily accessed content as well as a means for offloading data processing operations from a permanent data storage. Examples described herein extend to those in which data associated with an electronic file is already stored in cache memory as well as those in which update occurs directly to a permanent data storage and subsequently forwarded for validation processing.

Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

Abstract: The invention relates to a novel powder, it's method of manufacture and the use thereof in powder material processing, particularly in the manufacture of components formed from compacted powder e.g. discs, monoliths, layers or tablets. The powders comprise coated host particles wherein over 70% of the mass of the powder comprises coated particles smaller than 100 microns. The powders have particular application in the pharmaceutical industry and the technology described can be used to control the properties of active pharmaceutical ingredients. The powders (10) may comprise drug particles (12), carrier particles (14) and additives (16).

Abstract: This invention relates to drug delivery and in particular to the delivery of biologically active agents in the form of dry powders for inhalation. The invention also relates to methods for preparing such dry powder formulations and methods for their use.

Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.

Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.

Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.

Abstract: The present invention relates to particles and to methods of making particles. In particular, the invention relates to methods of making composite active particles comprising a pharmaceutically active material for pulmonary inhalation, the method comprising a jet milling process.

Abstract: The present invention is concerned with a refinement of the processing of particles that are to form a dry powder formulation which is to be administered to the lung using a dry powder inhaler (DPI) device. In particular, the present invention provides the processing of particles of active material and particles of carrier material in the presence of additive material to provide a powder composition which exhibits excellent powder properties and which is economical to produce.

Abstract: An infill balise is arranged upstream of a route component in the direction of travel. The infill balise receives information relating to a state of the route component, and the control of a rail vehicle is carried out by taking into account the state of the route component. Since the infill balise is positioned ahead of the route component, the rail vehicle can still react in good time to the state of the route component and, initiate a braking or an acceleration process. This reduces the delay and increases the safety as well as the efficiency in the railway mode, in particular if the route component lying ahead is located at the start of an area which is controlled by another interlock box. The infill balise is used instead of a block interface. This is advantageous because the implementation of block interfaces is challenging, complicated and costly.

Abstract: An infill balise is provided for making available a state of a route component (for example of a signal) which lies ahead in the direction of travel of a rail line. Depending on a state of the route component, the infill balise brings about a change of the European train control system (ETCS) mode of a rail vehicle if the rail vehicle is in a manual travel mode or is not in a monitored travel mode. The presented solution has the advantage that the infill balise can ensure safety even in a manual ETCS mode (for example a staff responsible mode or an on-site mode). The solution can preferably be used in conjunction with ETCS level 1 applications.