Abstract: Pyrrolidine main protease inhibitors are described that are effective as antiviral compounds.

Abstract: Various embodiments of a hermetic assembly and a method of forming such assembly are disclosed. The hermetic assembly includes a dielectric substrate having a first major surface and a second major surface, a patterned layer connected to the first major surface of the dielectric substrate by a laser bond, and a ferrule having a body and a flange extending from the body. The flange is welded to a welding portion of the patterned layer that is disposed between the flange and the first major surface of the dielectric substrate such that the ferrule is hermetically sealed to the dielectric substrate.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, ?v?1 integrin and ?v?6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).

Abstract: Various embodiments include systems, methods, and non-transitory computer-readable media for sharing and managing media galleries. Consistent with these embodiments, a method includes receiving a request from a first device to share a media gallery that includes a user avatar; generating metadata associated with the media gallery; generating a message associated with the media gallery, the message at least including the media gallery identifier and the identifier of the user avatar; and transmitting the message to a second device of the recipient user.

Abstract: A system and method for automatic identification of photocopied documents is disclosed wherein the method is performed by capturing an image of a marked printed document; decoding a digital watermark embedded in the image, obtaining a mark identifier; recovering, by searching a database, at least one calibration parameter associated with the mark identifier; applying a discrete Fourier transform to the image, obtaining a frequency matrix; obtaining at least one maximum frequency value in the frequency matrix; comparing the at least one maximum frequency value with at least one calibration parameter; determining, on the basis of the comparison, if the marked printed document is an original document or a photocopied document.

Abstract: In a method for a cooktop, in particular for producing and/or operating the cooktop, which has at least one variable cooking surface, the cooking surface is partitioned in an operating mode along a partitioning direction into a plurality of heating zones to which at least one heating parameter is assigned in each case in a location-dependent manner in order to heat a cooking utensil that is deposited on the heating zone. In order to ensure flexible production and/or flexible operation of the cooktop, during partitioning of the cooking surface into the heating zones in at least one peripheral region of the cooking surface, at least one cooking utensil characteristic is taken into account.

Abstract: A network device transmits data to a user equipment (UE) via a first Radio Access Network (RAN) using first Transmission Control Protocol (TCP) congestion control parameters. The network device receives a notification message indicating that the UE has moved from the first RAN to a second RAN. The network device modifies, responsive to receipt of the notification, the first TCP congestion control parameters to create second TCP congestion control parameters, where the first TCP congestion control parameters include a first slow start threshold (ssthresh), and wherein the second TCP congestion control parameters include a second ssthresh that is different than the first ssthresh. The network device transmits data to the UE via the second RAN using the second TCP congestion control parameters.

Abstract: A printing apparatus is disclosed herein. The apparatus comprises a platform defining a printing zone to hold a media moveable along a media path direction; a first sensor at a first location along the media path direction to measure a media advance at the first location; a second sensor located at a second location along the media path direction downstream the first location, the second sensor to measure the media advance at the second location; and a controller. The controller to determine a deformation gradient of the media based on a first set of measurements of the media advance by the sensors at the first and second locations and adjust an image to be printed based on the deformation gradient.

Abstract: The invention relates to a process for preparing high-density quercetin of improved flowability comprising roller compaction of quercetin, wherein both the obtained high-density quercetin and the quercetin starting material have a purity of at least 95%. The invention also relates to the high-density quercetin obtainable with such process, to the use of high-density quercetin for preparing pharmaceutical dosage forms, to pharmaceutical dosage forms comprising high-density quercetin as active ingredient, and to their use in therapy and in cosmetics.

Abstract: An apparatus is disclosed herein. The apparatus comprises a carriage to move laterally in a scanning direction over a platen, a scan beam to support the carriage over the platen, a mechanism to move the scan beam vertically, and a media holder. The media holder comprises a central portion to hold a media on the platen, a first end couplable to the platen at a coupling position, and a second end couplable to the scan beam such that the second end moves vertically along with the scan beam.

Abstract: Example implementations relate to substrate porosity determination. Some examples refer to a substrate porosity determination comprising an image capture device a controller to obtain a reference image by the image capture device; obtain a measurement image after a printing operation has been performed on a substrate located over the image capture device; compare the reference image and the measurement image—determine whether the substrate is porous based on the comparison; and determine a print parameter based on the determination of whether the substrate is porous.

Abstract: A method to control a robot to perform at least one Cartesian or joint space task comprises using quadratic programming to determine joint forces, in particular joint torques, and/or joint accelerations of said robot based on at least one cost function which depends on said task.

Abstract: A printing apparatus is disclosed. The printing apparatus comprises a printhead and a controller. The printhead is to spit a printing fluid comprising a first mode and a second mode. The first mode corresponds to using a first energy level to spit the printing fluid and the second mode corresponds to using a second energy level to spit the printing fluid. The second energy level comprises a higher energy level than the first energy level. The controller is to determine a decap risk zone associated with the printing fluid, determine in view of the decap risk zone a decap location, and instruct the printhead to spit using the second mode at the decap location.

Abstract: A method includes: supporting a normal operation mode, during which functionalities of a portable apparatus are available through an operating system of the apparatus, wherein the operating system includes a plurality of layers including a kernel and library functions layer; supporting a limited operation mode during which the apparatus is configured to execute a physical activity algorithm based on physical activity data corresponding to a physical activity session performed by a user of the apparatus, wherein the physical activity algorithm applies a direct low-level hardware access bypassing at least the layers above the kernel and the library functions-layer; and switching between the normal operation mode and the limited operation mode.

Abstract: A system is disclosed. The system comprises a roller with a spindle to wind and/or unwind a roll of media, a media advancement sensor to measure the advancement of the media, and a controller. The controller is to control the spindle to rotate an angular displacement, and to determine a calculated media advancement based on the angular displacement and a radius of the roll of media. The controller is also to receive from the media advancement sensor a measured media advancement. The controller is further to detect that a displacement difference between the measured media advancement and the determined media advancement exceeds a predetermined threshold. If the displacement difference exceeds the predetermined threshold a slippage condition is detected.

Abstract: Obstacle detection for a moving element activated by a motor is disclosed. The obstacle detection may comprise a controller to: move the element at a substantially constant speed; determine an actual torque value to move the element at the constant speed; determine a torque parameter based on the actual torque value; comparing the torque parameter with a threshold value; and determining the presence of an obstacle if the torque parameter is above the torque parameter threshold; wherein the torque parameter is determined based on a set of historical torque values and the actual torque value.

Abstract: A method for the automatic adjustment of a cockpit inside a road vehicle comprising the steps of determining anthropometric data of a driver; processing an ergonomic position of a model of the driver sitting on board the road vehicle; processing an optimal configuration of the cockpit; operating a plurality of actuator systems so as to cause the cockpit to reach the optimal configuration; wherein the ergonomic position of the model is processed in association with a minimum ground visibility; a minimum visibility of a control panel; and at least one first comfort angle of a body joint of the driver.

Abstract: A network device transmits data to a user equipment (UE) via a first Radio Access Network (RAN) using first Transmission Control Protocol (TCP) congestion control parameters. The network device receives a notification message indicating that the UE has moved from the first RAN to a second RAN. The network device modifies, responsive to receipt of the notification, the first TCP congestion control parameters to create second TCP congestion control parameters, where the first TCP congestion control parameters include a first slow start threshold (ssthresh), and wherein the second TCP congestion control parameters include a second ssthresh that is different than the first ssthresh. The network device transmits data to the UE via the second RAN using the second TCP congestion control parameters.

Abstract: A network device transmits data to a user equipment (UE) via a first Radio Access Network (RAN) using first Transmission Control Protocol (TCP) congestion control parameters. The network device receives a notification message indicating that the UE has moved from the first RAN to a second RAN, and modifies, responsive to receipt of the notification, the first TCP congestion control parameters to create second TCP congestion control parameters. The network device transmits data to the UE via the second RAN using the second TCP congestion control parameters.

Abstract: A printing apparatus is disclosed. The printing apparatus comprises a printhead and a controller. The printhead is to spit a printing fluid comprising a first mode and a second mode. The first mode corresponds to using a first energy level to spit the printing fluid and the second mode corresponds to using a second energy level to spit the printing fluid. The second energy level comprises a higher energy level than the first energy level. The controller is to determine a decap risk zone associated with the printing fluid, determine in view of the decap risk zone a decap location, and instruct the printhead to spit using the second mode at the decap location.