Abstract: The present invention relates generally to methods of detecting and identifying known and unknown viruses using hybridization microarrays to known conserved and non-conserved viral nucleotide sequences, the sequencing of nucleotides which hybridize to the microarrays and analysis of the hybridized sequences with existing databases, thus identifying existing or new subtypes of viruses.

Abstract: A fire suppressant system having a pipe system, spray nozzles connected to the pipe system and a control system for selectively charging the pipe system with foam. The control system includes a pilot line for generating a signal based upon sensing an environmental parameter and a first control valve for activating the system based upon the signal. Preferably, the first control valve forms i) an interior cavity for mixing the compressed air and compressed air liquid, ii) an outlet in fluid communication with the interior; iii) a first inlet, oriented substantially perpendicular to a flow through the outlet, in fluid communication with the interior and the compressed air; and iv) a second inlet, oriented substantially perpendicular to the flow, in fluid communication with the interior and the compressed air liquid.

Abstract: The invention provides a microarray and methods for producing a protein microarray. The array comprises multiple nucleic acid molecules immobilized on a substrate, each comprising (i) a protein-binding domain and (ii) a nucleic acid sequence encoding a fusion protein comprising a polypeptide of interest and a DNA-binding protein that binds the protein-binding domain, and one or more fusion proteins produced from the multiple nucleic acid molecules. Each fusion protein is immobilized on the substrate via binding to a nucleic acid sequence comprising the protein-binding domain present on the nucleic acid molecule from which the fusion protein is produced or on the substrate. The invention also provides a method of analyzing protein interactions with, for example, other proteins, lipids and drugs.

Abstract: Methods for isolating ZAP-3 genes are provided. Deletion of the ZAP-3 locus is associated with human tumors, particularly carcinomas. The ZAP-3 nucleic acid compositions find use in identifying homologous or related proteins and the DNA sequences encoding such proteins; in producing compositions that modulate the expression or function of the protein; and in studying associated physiological pathways. In addition, modulation of the gene activity in vivo is used for prophylactic and therapeutic purposes, such as treatment of cancer, identification of cell type based on expression, and the like.