Abstract: This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of fatty acid synthase (FAS). Suitably, the present invention relates to the use of benzimidazoles in the treatment of cancer.

Abstract: An integrated pet environment for a mobile vehicle. The integrated pet environment will consist of two pet care units, one located behind the driver's seat and the other located behind the passenger's seat. The driver's seat unit will have storage for pet supplies, and will have a gate which the driver can easily reach with one hand while driving to close off his/her seat, preventing the dog from disturbing him/her while he/she is driving. The passenger's seat unit will have more storage plus a ramp for the dog. The passenger's seat itself will fold all the way down forward and will provide a seat for the dog, accessible from the back of the truck, which will not allow the dog to reach the driver. One of the two storage units will also have food and water dishes.

Abstract: A crystal structure of the cfms kinase domain, co-crystal structure with a bound small molecule, as well as methods of using the same in the discovery of cfms inhibitors and in the treatment of diseases mediated by inappropriate cfms activity.

Abstract: An integrated pet environment for a mobile vehicle. The integrated pet environment will consist of two pet care units, one located behind the driver's seat and the other located behind the passenger's seat. The driver's seat unit will have storage for pet supplies, and will have a gate which the driver can easily reach with one hand while driving to close off his/her seat, preventing the dog from disturbing him/her while he/she is driving. The passenger's seat unit will have more storage plus a ramp for the dog. The passenger's seat itself will fold all the way down forward and will provide a seat for the dog, accessible from the back of the truck, which will not allow the dog to reach the driver. One of the two storage units will also have food and water dishes.

Abstract: Disclosed is the compound (+)-(2S,3S)-2-(3-chlorophenyl)-3,5,5-trimethyl-2-morpholinol and pharmaceutically acceptable salts and solvates thereof, pharmaceutical compositions comprising them, and processes for their preparation and use; also disclosed is a method of treating depression, attention deficit hyperactivity disorder (ADHD), obesity, migraine, pain, sexual dysfunction, Parkinson's disease, Alzheimer's disease, or addiction to cocaine or nicotine-containing (especially tobacco) products using such compound, salts, solvates or compositions.

Abstract: The present invention provides a weight redistribution system including an axle carrier slideably engaged along a length of a trailer frame, wherein the axle carrier including a threaded fixture and the trailer frame includes parallel longitudinal beams having a plurality of equally spaced openings; an axle carrier positioning means including a motor means and a threaded shaft mounted to the trailer frame being in rotational engagement with the threaded fixture of the axle carrier; a weight monitoring system integrated into the axle carrier; an axle carrier locking means including at least one extendable pin mounted on the axle carrier for locking engagement into one of the equally spaced openings in the longitudinal beams; and a control interface for displaying data from the weight monitoring system, actuating the axle carrier positioning means, and actuating the axle carrier locking means.

Abstract: A variety of small molecule, guanidine-containing molecules capable of acting as MC4-R agonists are provided. The compounds are useful in treating MC4-R mediated diseases when administered to subjects. The compounds have the structure IA, IB, and IC where the values of the variables are defined herein.