Abstract: Disclosed is a front obstacle alerting system comprising an obstacle-side signal emitting device and a vehicle-side alerting device, wherein the obstacle-side signal emitting device is a signal emitting element of a front obstacle and emits a directional ultrasonic wave toward a rear side of the front obstacle, and the vehicle-side alerting device is disposed in or on a vehicle and correspondingly outputs an alerting signal according to the directional ultrasonic wave received from a front side of the vehicle.

Abstract: Disclosed is a front obstacle alerting system comprising an obstacle-side signal emitting device and a vehicle-side alerting device, wherein the obstacle-side signal emitting device is a signal emitting element of a front obstacle and emits a directional ultrasonic wave toward a rear side of the front obstacle, and the vehicle-side alerting device is disposed in or on a vehicle and correspondingly outputs an alerting signal according to the directional ultrasonic wave received from a front side of the vehicle.

Abstract: A laser system for modification of a sample to form a modified region at a target location within the sample, the target location being disposed below a surface of the sample, the laser system comprising: a laser light source configured to provide laser light; a sample holder for supporting the sample; one or more optical elements configured to direct the laser light from the laser light source into the sample when the sample is supported by the sample holder, wherein the one or more optical elements are configured to focus the laser light into the sample, and wherein the one or more optical elements includes a component configured to correct for spherical aberration caused by mismatch in refractive index at the surface of the sample through which the laser light enters the sample such that the laser light is focused at the target location within the sample, a tilt measurement device configured to measure a tilt angle of the surface of the sample relative to an optical axis of the laser light entering through

Abstract: The present invention is directed to compounds, compositions thereof, and the use of the compounds and compositions for the treatment and prevention of breast cancer. In one embodiment, the present invention relates to the use of a substituted triphenyl butene or prodrug thereof for the treatment of breast cancer in mono-therapy or in combination therapy, or for a reduction in the recurrence rate of previously-treated breast cancer.

Abstract: The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.

Abstract: Antifungal compounds represented by formula I where R1, R2, R3 and R4 are as defined herein. Isolated or purified naturally occurring 20,21-dihydro ambruticin compounds. The invention also provides Sorangium cellulosum ambM, ambO, ambP, and ambS mutant strains; a recombinant Sorangium cellulosum strain that produces 24-norambruticin compounds; and a method for treating a fungal infection using a compound of this invention.

Abstract: Compounds having a structure according to formula (I) where RA, RB, RC, RD, RE, and RF are as defined herein, are useful as prokinetic agents.

Abstract: Sixteen membered macrolide anti-infective agents having a structure according to formula I where R1, R2, R3, R4, R5, and R6 are as defined herein, and related compounds are disclosed.

Abstract: Leptomycin-type compounds according to Formula I wherein R0, R1, R2, R10, R11, R12, R13, R14, and m are as defined herein, exhibit anti-tumor activity.

Abstract: Compounds according to formula I wherein m is 0 or 1; X is and R1, R2, R3 R4, and R5 are as defined herein, are useful as anti-infective agents.

Abstract: The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.

Abstract: 9-Desoxoerythromycin compounds of formula I wherein R1, R2, R3, R4, and R5 are as defined herein, are useful as prokinetic agents for treating disorders of gastric motility.

Abstract: A vehicle alert kit includes at least one base member having a substantially planar bottom surface and a threaded portion integral therewith. The kit further includes a mechanism for fastening at least one base member to a surface so that same can be maintained at a substantially secure position. The kit further includes an elongated support member having a lower end portion threadably attachable to a select one of at least one base member. The elongated support member extends substantially vertically and upwardly from the base member to a predetermined height, and includes a receiving portion extending substantially vertically along a length thereof and having a bottom surface. The kit further includes a flag having indicia printed thereon and including an edge portion selectively engageable with the receiving portion.

Abstract: Compounds and methods useful for the synthesis of (+)-discodermolide, a naturally occurring microtubule stabilizing agent useful as an anti-cancer agent.

Abstract: Compounds of formula (I) wherein A is and R1, R2, R3, and R4 are as defined herein, are prokinetic agents and can be used to treat disorders of gastric motility.

Abstract: Compounds having a structure according to formula I wherein the groups R1 and R4 are as defined in the specification, are useful as anti-proliferative agents.

Abstract: Synthetic methods and intermediates useful in the preparation of lactone containing compounds such as discodermolide and compounds which mimic the chemical or biological activity of discodermolide are provided.

Abstract: 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents.

Abstract: The present invention provides new trans-9,10-dehydroepothilone C and trans-9,10-dehydroepothilone D based derivative compounds, compositions and methods of inhibiting cellular hyperproliferation and/or stabilizing microtubules in vitro and of treatment of hyperproliferative diseases in vivo. Also disclosed are methods of making the compounds.

Abstract: The present invention provides 14-methyl epothilone compounds, along with intermediates thereto, methods for their preparation, compositions comprising the compounds, and methods for their use in the treatment of cancer and other diseases and conditions characterized by undesired cellular hyperproliferation.