Patents by Inventor David N. Fredricks

David N. Fredricks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10690651
    Abstract: The invention disclosed herein generally relates to methods and kits for diagnosing, assessing disease risk, treating, and preventing bacterial vaginosis (BV) and associated conditions. Additional embodiments include methods for developing metabolic profiles associated with increased disease risk, and developing new approaches to treat BV based on interrupting metabolic networks.
    Type: Grant
    Filed: April 13, 2016
    Date of Patent: June 23, 2020
    Assignee: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Sujatha Srinivasan, David N. Fredricks
  • Publication number: 20180113109
    Abstract: The invention disclosed herein generally relates to methods and kits for diagnosing, assessing disease risk, treating, and preventing bacterial vaginosis (BV) and associated conditions. Additional embodiments include methods for developing metabolic profiles associated with increased disease risk, and developing new approaches to treat BV based on interrupting metabolic networks.
    Type: Application
    Filed: April 13, 2016
    Publication date: April 26, 2018
    Inventors: Sujatha SRINIVASAN, David N. Fredricks
  • Patent number: 9803250
    Abstract: Disclosed herein are methods for detecting a fungal pathogen in a patient sample, involving isolating the sample, carrying out a PCR reaction on the sample to generate an amplicon that includes a region of the fungal 28S ribosomal RNA gene, and detecting the PCR amplicon. Also disclosed are sequences of primers for specifically detecting a broad range of fungal pathogens in the presence of human ribosomal DNA. In certain embodiments, the amplicon is detected by sequencing or by two-dimensional melt-curve analysis. In yet other embodiments, more than one fungal pathogen is detected in a sample using the methods disclosed herein.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: October 31, 2017
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: David N. Fredricks, Prasanna D. Khot, Daisy L. Ko
  • Patent number: 8450059
    Abstract: Provided are quantitative PCR-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis (IPA) in a patient sample, such as bronchoalveolar lavage (BAL) fluid. The methods presented herein involve isolating a patient sample, optionally extracting DNA from the sample, carrying out a quantitative PCR (qPCR) reaction on the sample to generate an amplicon that includes a region of an Aspergillus spp. ribosomal RNA (rRNA) gene, and detecting the PCR amplicon. The present disclosure also provides primers and primer sets for specifically detecting an Aspergillus spp. fungal pathogen in the presence of human ribosomal DNA (rDNA).
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: May 28, 2013
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: David N. Fredricks, Prasanna D. Khot, Daisy L. Ko
  • Publication number: 20100273169
    Abstract: Provided are quantitative PCR-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis (IPA) in a patient sample, such as bronchoalveolar lavage (BAL) fluid. The methods presented herein involve isolating a patient sample, optionally extracting DNA from the sample, carrying out a quantitative PCR (qPCR) reaction on the sample to generate an amplicon that includes a region of an Aspergillus spp. ribosomal RNA (rRNA) gene, and detecting the PCR amplicon. The present disclosure also provides primers and primer sets for specifically detecting an Aspergillus spp. fungal pathogen in the presence of human ribosomal DNA (rDNA).
    Type: Application
    Filed: April 27, 2010
    Publication date: October 28, 2010
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: DAVID N. FREDRICKS, PRASANNA D. KHOT, DAISY L. KO
  • Publication number: 20100129821
    Abstract: Disclosed herein are methods for detecting a fungal pathogen in a patient sample, involving isolating the sample, carrying out a PCR reaction on the sample to generate an amplicon that includes a region of the fungal 28S ribosomal RNA gene, and detecting the PCR amplicon. Also disclosed are sequences of primers for specifically detecting a broad range of fungal pathogens in the presence of human ribosomal DNA. In certain embodiments, the amplicon is detected by sequencing or by two-dimensional melt-curve analysis. In yet other embodiments, more than one fungal pathogen is detected in a sample using the methods disclosed herein.
    Type: Application
    Filed: November 24, 2009
    Publication date: May 27, 2010
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: David N. Fredricks, Prasanna D. Khot, Daisy L. Ko
  • Patent number: 7625704
    Abstract: The present invention provides methods and compositions for identifying bacteria associated with bacterial vaginosis and diagnosing bacterial vaginosis in a subject.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: December 1, 2009
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: David N. Fredricks, Tina Fiedler