Abstract: A method and apparatus for synthesizing a set of optimal sensory stimuli designed to elicit an optimal response for each particular brain electrode location in a subject whose brain is being examined to anatomically localize brain dysfunction. A pseudorandom input signal having the general characteristics of Gaussian white noise is generated and converted into a color video visual stimulus which can be observed by the subject and summed on his retina and associated neural network. A plurality of electrodes are positioned with respect to various different and distinct areas of the brain of the subject to be examined. The subject is shown the color video visual stimulus and the electrical analog response from the electrodes is amplified and stored. The stored analog response signals are cross-correlated with the resynthesized input signal to compute a Wiener kernel representation of the response for each electrode.