Patents by Inventor David N. Zacks

David N. Zacks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE COMPOSITIONS AND METHODS OF USE
    Publication number: 20230287052
    Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas-or TRAIL-mediated apoptosis.
    Type: Application
    Filed: January 24, 2023
    Publication date: September 14, 2023
    Inventors: Cagri G. BESIRLI, Alexander J. BRIDGES, John K. FRESHLEY, William A. HUNKE, Linda L. JOHNSON, Francis X. SMITH, Ethan SYLVAIN, David N. ZACKS
  • Peptide compositions and methods of use
    Patent number: 11597749
    Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.
    Type: Grant
    Filed: October 6, 2020
    Date of Patent: March 7, 2023
    Assignees: THE REGENTS OF THE UNIVERSITY OF MICHIGAN, ONL THERAPEUTICS, INC.
    Inventors: Cagri G. Besirli, Alexander J. Bridges, John K. Freshley, William A. Hunke, Linda L. Johnson, Francis X. Smith, Ethan Sylvain, David N. Zacks
  • PEPTIDE COMPOSITIONS AND METHODS OF USE
    Publication number: 20210094985
    Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.
    Type: Application
    Filed: October 6, 2020
    Publication date: April 1, 2021
    Inventors: Cagri G. BESIRLI, Alexander J. BRIDGES, John K. FRESHLEY, William A. HUNKE, Linda L. JOHNSON, Francis X. Smith, Ethan SYLVAIN, David N. ZACKS
  • Peptide compositions and methods of use
    Patent number: 10829518
    Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.
    Type: Grant
    Filed: November 4, 2019
    Date of Patent: November 10, 2020
    Assignees: ONL THERAPEUTICS. INC., THE REGENT OF THE UNIVERSITY OF MICHIGAN
    Inventors: Cagri G. Besirli, Alexander J. Bridges, John K. Freshley, William A. Hunke, Linda L. Johnson, Francis X. Smith, Ethan Sylvain, David N. Zacks
  • PEPTIDE COMPOSITIONS AND METHODS OF USE
    Publication number: 20200123201
    Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.
    Type: Application
    Filed: November 4, 2019
    Publication date: April 23, 2020
    Applicants: ONL Therapeutics, Inc., The Regents of the University of Michigan
    Inventors: Cagri G. BESIRLI, Alexander J. BRIDGES, John K. FRESHLEY, William A. HUNKE, Linda L. JOHNSON, Francis X. SMITH, Ethan SYLVAIN, David N. ZACKS
  • Peptide compositions and methods of use
    Patent number: 10508134
    Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.
    Type: Grant
    Filed: April 29, 2016
    Date of Patent: December 17, 2019
    Assignees: ONL Therapeutics, Inc., The Regents Of The University of Michigan
    Inventors: Cagri G. Besirli, Alexander J. Bridges, John K. Freshley, William A. Hunke, Linda L. Johnson, Francis X. Smith, Ethan Sylvain, David N. Zacks
  • PEPTIDE COMPOSITIONS AND METHODS OF USE
    Publication number: 20180291062
    Abstract: Provided herein are compositions including peptides, pharmaceutical preparations thereof, and methods of preventing photoreceptor death therewith and protecting of retinal cells, including, but not limited to, photoreceptors and retinal pigment epithelium, from Fas- or TRAIL-mediated apoptosis.
    Type: Application
    Filed: April 29, 2016
    Publication date: October 11, 2018
    Applicants: ONL Therapeutics, Inc., The Regents of the University of Michigan
    Inventors: Cagri G. BESIRLI, Alexander J. BRIDGES, John K. FRESHLEY, William A. HUNKE, Linda L. JOHNSON, Francis X. SMITH, Ethan SYLVAIN, David N. ZACKS
  • Methods and Compositions for Preserving the Viability of Photoreceptor Cells
    Publication number: 20180000930
    Abstract: Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.
    Type: Application
    Filed: February 16, 2017
    Publication date: January 4, 2018
    Inventors: David N. Zacks, Joan Miller
  • Methods and Compositions for Preserving the Viability of Photoreceptor Cells
    Publication number: 20160144024
    Abstract: Provided are methods and compositions for maintaining the viability of photoreceptor cells following retinal detachment. The viability of photoreceptor cells can be preserved by administering an apoptosis inhibitor to a mammal having an eye with retinal detachment. The apoptosis inhibitor maintains the viability of the photoreceptor cells until such time that the retina becomes reattached to the underlying retinal pigment epithelium and choroid. The treatment minimizes the loss of vision, which otherwise may occur as a result of retinal detachment.
    Type: Application
    Filed: July 29, 2015
    Publication date: May 26, 2016
    Inventors: David N. Zacks, Joan Miller
  • COMPOSITIONS FOR TREATMENT OF RETINAL DETACHMENT
    Publication number: 20160015770
    Abstract: Provided herein are compositions and methods for the treatment and/or prevention of retinal detachment. In particular, calpain inhibition is used to prolong autophagy and delay apoptosis associated with retinal detachment.
    Type: Application
    Filed: March 12, 2014
    Publication date: January 21, 2016
    Inventors: David N. Zacks, Nicholas Chinskey
  • Methods of inhibiting photoreceptor apoptosis by eliciting the Faim2 antiapoptotic pathway
    Patent number: 9192650
    Abstract: The present invention provides compositions and methods to prevent apoptosis. In particular, provided herein are compositions and methods which prevent FAS-mediated photoreceptor apoptosis.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: November 24, 2015
    Assignee: The Regents of the University of Michigan
    Inventors: David N. Zacks, Cagri Besirli
  • COMPOSITIONS AND METHODS OF INHIBITING PHOTORECEPTOR APOPTOSIS
    Publication number: 20130053328
    Abstract: The present invention provides compositions and methods to prevent apoptosis. In particular, provided herein are compositions and methods which prevent FAS-mediated photoreceptor apoptosis.
    Type: Application
    Filed: August 30, 2012
    Publication date: February 28, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David N. Zacks, Cagri Besirli
  • COMPOSITIONS AND METHODS FOR DETECTING AND TREATING OPHTHALMIC DISORDERS
    Publication number: 20090081159
    Abstract: The present invention relates to compositions and methods for the detecting, treating, and conducting research on ophthalmic disorders associated with photoreceptor cell death and/or retinal insult. In particular, the present invention provides compositions and methods for increasing IL-6 expression and/or activity (e.g., exogenous IL-6), activating IL-6 receptors (e.g., IL-6R, sIL6-R), activating pathway related compounds (e.g., STAT, FLIP), and/or activating related pathways (e.g., JAK/STAT pathway, TGF-? pathway, Ahr pathway) in the diagnosis, treatment, and conducting research of ophthalmic disorders associated with photoreceptor cell death and/or retinal insult (e.g., retinal detachment).
    Type: Application
    Filed: September 19, 2008
    Publication date: March 26, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: David N. Zacks