Patents by Inventor David Nazzaro

David Nazzaro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240269379
    Abstract: Disclosed are examples for a system for drug delivery and components thereof. The system may include an on-body pump device and a secondary unit. The on-body pump device may include a reservoir and a fluid pathway. The reservoir may be configured to hold a liquid drug. The secondary unit may be removably coupled to the on-body pump device. The secondary unit may be configured to receive a prefilled cartridge containing a liquid drug, expel the liquid drug from the prefilled cartridge, and deliver the liquid drug to the reservoir of the on-body pump device via the fluid pathway. Examples of variations to the secondary unit are also disclosed.
    Type: Application
    Filed: April 23, 2024
    Publication date: August 15, 2024
    Inventors: Jason O'CONNOR, Ian MCLAUGHLIN, Daniel ALLIS, David NAZZARO
  • Publication number: 20240252753
    Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide an updated insulin-to-carbohydrate ratio and an updated total daily insulin. The described processes may be used for periodic updating of the insulin-to-carbohydrate ratio and the total daily insulin. The insulin-to-carbohydrate ratio and/or the total may be used in the calculation of new doses of insulin that a drug delivery device may be commanded to deliver to a user.
    Type: Application
    Filed: April 12, 2024
    Publication date: August 1, 2024
    Inventors: Yibin ZHENG, Joon Bok LEE, Steven CARDINALI, Jason O'CONNOR, Eric BENJAMIN, Ian MCLAUGHLIN, David NAZZARO, Ashutosh ZADE
  • Publication number: 20240181156
    Abstract: Disclosed are systems, processes and techniques implementable in and by medical devices that utilize the subcutaneous region of the skin. In the disclosed examples, an insertion mechanism is provided that inserts a cannula or sensing element into the subcutaneous region of the skin a first distance and retracts the inserted cannula or sensing element a second distance that is smaller than the first distance to create a cavity below the inserted cannula or sensing element. The retracted cannula or sensing element remains inserted in the subcutaneous region of the skin. The cavity provides an area for the effects of a wound response to occur and thereby mitigates possibility of occlusion and/or encapsulation of the inserted cannula or sensing element.
    Type: Application
    Filed: November 29, 2023
    Publication date: June 6, 2024
    Inventors: James CAUSEY, David NAZZARO
  • Patent number: 11992653
    Abstract: Disclosed are examples for a system for drug delivery and components thereof. The system may include an on-body pump device and a secondary unit. The on-body pump device may include a reservoir and a fluid pathway. The reservoir may be configured to hold a liquid drug. The secondary unit may be removably coupled to the on-body pump device. The secondary unit may be configured to receive a prefilled cartridge containing a liquid drug, expel the liquid drug from the prefilled cartridge, and deliver the liquid drug to the reservoir of the on-body pump device via the fluid pathway. Examples of variations to the secondary unit are also disclosed.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: May 28, 2024
    Assignee: INSULET CORPORATION
    Inventors: Jason O'Connor, Ian McLaughlin, Daniel Allis, David Nazzaro
  • Patent number: 11957875
    Abstract: Disclosed are a device, system, methods and computer-readable medium products that provide an updated insulin-to-carbohydrate ratio and an updated total daily insulin. The described processes may be used for periodic updating of the insulin-to-carbohydrate ratio and the total daily insulin. The insulin-to-carbohydrate ratio and/or the total may be used in the calculation of new doses of insulin that a drug delivery device may be commanded to deliver to a user.
    Type: Grant
    Filed: December 4, 2020
    Date of Patent: April 16, 2024
    Assignee: INSULET CORPORATION
    Inventors: Yibin Zheng, Joon Bok Lee, Steven Cardinali, Jason O'Connor, Eric Benjamin, Ian McLaughlin, David Nazzaro, Ashutosh Zade
  • Publication number: 20230364329
    Abstract: Exemplary embodiments may provide a medicament delivery device that includes a single instrument for piercing the skin of the user and for acting as a conduit for delivering medicament to the user subcutaneously. The exemplary embodiments may reduce discomfort caused by a rigid cannula or needle. The exemplary embodiments may provide instruments that are configured to be comfortable to the user when the instruments are in place beneath the skin of the user, such as when a medicament delivery device is delivering medicament to the user.
    Type: Application
    Filed: May 8, 2023
    Publication date: November 16, 2023
    Inventors: Jianhong ZHAO, David NAZZARO, Lucas MCGAHREN, Eric DUHAMEL
  • Publication number: 20230347053
    Abstract: The exemplary embodiments may detect the changed ambient air pressure and may adjust settings for the medicament delivery device to compensate for the changed ambient air pressure. The exemplary embodiments may detect the changed ambient air pressure and may adjust settings for the medicament delivery device to compensate for the changed ambient air pressure. Based on the detection of these events, the medicament delivery device may be switched into a flight mode. In the flight mode, medicament boluses may be reduced to nominal dosages, basal delivery rates may be modified and sample periods for sensors, like glucose monitors, may be shortened to sample sensor values more frequently. The exemplary embodiments may prohibit delivery of medicament during times of changing ambient air pressure to avoid over-delivering or under-delivering the medicament due to the ambient air pressure level.
    Type: Application
    Filed: April 24, 2023
    Publication date: November 2, 2023
    Inventors: David NAZZARO, Rangarajan NARAYANASWAMI
  • Patent number: 11786668
    Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can include a spring coupled to a plurality of force transfer elements. The force transfer elements can have a variety of shapes and configurations.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: October 17, 2023
    Assignee: INSULET CORPORATION
    Inventors: David Nazzaro, Ian McLaughlin, Jeff Barnes, Daniel Allis
  • Publication number: 20230277762
    Abstract: Disclosed herein is a combination of an automated insulin delivery system and a continuous glucose monitor integrated into a single, wearable package. The system may use any combination of delivery methods and detection methods, wherein the delivery methods include a cannula, a microneedle array, and a transdermal patch, and wherein the detection methods include electrochemical methods, opto-fluorescent methods, and spectrographic methods.
    Type: Application
    Filed: March 1, 2023
    Publication date: September 7, 2023
    Inventors: Eric DUHAMEL, John D′ARCO, David NAZZARO, James CAUSEY
  • Patent number: 11744944
    Abstract: Systems and methods for automatically delivering medication to a user. A sensor coupled to a user can collect information regarding the user. A controller can use the collected information to determine an amount of medication to provide the user. The controller can instruct a drug delivery device to dispense the medication to the user. The drug delivery device can be a wearable insulin pump that is directly coupled to the user. The controller can be part of or implemented in a cellphone. A user can be required to provide a confirmation input to allow a determined amount of insulin to be provided to the user based on detected glucose levels of the user. The sensor, controller, and drug delivery device can communicate wirelessly.
    Type: Grant
    Filed: June 11, 2020
    Date of Patent: September 5, 2023
    Assignee: INSULET CORPORATION
    Inventors: Jason O'Connor, Daniel Allis, David Nazzaro, John R. Bussiere, John D'Arco
  • Publication number: 20230233757
    Abstract: Fluid delivery devices with passive or pressure-based control valves are described. For example, a fluid delivery device may include a fluid path, a pressure source fluidically coupled to a fluid source storing a fluid, and a pressure-based control valve arranged in the fluid path and configured to move in an opening direction in response to a fluid delivery pressure applied by the pressure source in an upstream portion of the fluid path against the pressure-based control valve, in which the pressure control valve is in an open configuration responsive to the fluid delivery pressure being equal to or greater than a cracking pressure. In some embodiments, the pressure-based control valve may be or may include a bourdon tube. Other embodiments are described.
    Type: Application
    Filed: January 20, 2023
    Publication date: July 27, 2023
    Inventor: David NAZZARO
  • Patent number: 11672917
    Abstract: Drive systems for a drug delivery device are provided. The drive systems can be positioned within a container that stores a liquid drug to be delivered to a user. The drive systems can be coupled to a plunger positioned within the container. The drive systems can be incrementally advanced to drive the plunger further into the container, thereby expelling a portion of the stored liquid drug from the container for delivery to the user. The container can be any type of container including a pre-filled, standardized drug cartridge. The drive systems and container can be components of a wearable drug delivery device.
    Type: Grant
    Filed: September 30, 2020
    Date of Patent: June 13, 2023
    Assignee: INSULET CORPORATION
    Inventors: Steven Cardinali, David Nazzaro, Daniel Allis, Maureen McCaffrey
  • Patent number: 11660389
    Abstract: Disclosed are examples of reservoir and reservoir systems usable with a wearable drug delivery device. An example reservoir may include a flexible component coupled to a shell component. The shell component may include drainage channels to facilitate extraction of the liquid drug from the reservoir. A reservoir system example may include an exoskeleton configured around a flexible reservoir to guide the expansion and collapse of the flexible reservoir. Alternatively, one or more rigid panels may be coupled to corresponding flat surfaces of the flexible reservoir to guide the expansion and collapse of the flexible reservoir. A further reservoir example may include a flexible thin film reservoir having peel-able restraints configured to seal off corresponding sections of the reservoir, sequentially break, enabling the liquid drug to sequentially fill corresponding sections in a controlled and predicable manner. A wearable drug delivery device example suitable for utilizing the described examples is provided.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: May 30, 2023
    Assignee: INSULET CORPORATION
    Inventors: Jeff Barnes, Jackie Mac, Ian McLaughlin, David Nazzaro, Steven Cardinali, Thomas Metzmaker
  • Patent number: 11633541
    Abstract: Drug delivery systems with reduced hold-up volumes are provided. The drug delivery systems include a cartridge configured to hold a liquid drug. A cartridge stopper is positioned in a first portion of the cartridge. A needle guide component is positioned within the cartridge stopper. A needle is positioned within a central opening of the needle guide. A plunger is positioned in a second portion of the cartridge. The plunger includes a fluid path pocket facing and aligned with the central opening of the needle guide component. The plunger is driven toward the cartridge stopper to expel the liquid drug from the cartridge through the needle. An end of the needle can be positioned within the fluid path pocket when the plunger is pushed against the cartridge stopper, ensuring that only a small volume of the liquid drug remains in the cartridge when delivery of the liquid drug is completed.
    Type: Grant
    Filed: February 19, 2020
    Date of Patent: April 25, 2023
    Assignee: INSULET CORPORATION
    Inventors: Maureen McCaffrey, David Nazzaro, Ian McLaughlin, Simon Kozin
  • Publication number: 20230063696
    Abstract: Systems and methods for monitoring an operational state and/or a fill status of a drug container of a drug delivery device are provided. The drug container can hold a liquid drug. A plunger can be positioned within the drug container. A drive system can advance the plunger to expel the liquid drug from the container. A monitoring system can detect a movement and/or a position of the plunger and/or any component coupled to the plunger. The detection can enable determination of an amount of liquid drug that has been expelled and/or an amount of liquid drug remaining in the drug container. Dosing rates, flow rates, and dosage completion can also be determined.
    Type: Application
    Filed: October 11, 2022
    Publication date: March 2, 2023
    Inventors: David NAZZARO, Ian MCLAUGHLIN, Daniel ALLIS, Simon KOZIN, Maureen MCCAFFREY
  • Publication number: 20230067014
    Abstract: The exemplary embodiments may account for a change in potency of a medicament and adjust the dosage of medicament delivered to a user via a medicament delivery device to compensate for the change in potency. The medicament delivery device may determine the amount of change in the potency in the medicament and may make the adjustment in dosage of the medicament delivered to the user automatically without user input. The net result in that the dosage of medicament delivered to the user is better matched to the user's true need for the medicament.
    Type: Application
    Filed: August 24, 2022
    Publication date: March 2, 2023
    Inventors: Joon Bok LEE, John D'ARCO, David NAZZARO, Yibin ZHENG, Jason O'CONNOR
  • Patent number: 11551802
    Abstract: Disclosed are examples of a device, a system, methods and computer-readable medium products operable to implement functionality to determine and respond to a purpose of a meal. An algorithm or application may receive data that may include data related to a meal purpose from data sources and determine whether any of the data received from the plurality of data sources was received from a direct data source or an indirect data source. The data may be evaluated to determine a purpose of the meal. Based on the results of the evaluation, instructions may be generated to provide an appropriate response based on the determined purpose of the meal. The generated instructions to provide the appropriate response based on the determined purpose of the meal may be output.
    Type: Grant
    Filed: February 11, 2020
    Date of Patent: January 10, 2023
    Assignee: INSULET CORPORATION
    Inventors: David Nazzaro, Steven Cardinali, Nicholas Conte, Daniel Allis, Jason O'Connor, Joon Bok Lee, Ashutosh Zade, Timothy Henning, Thomas Metzmaker, Ian McLaughlin
  • Patent number: 11497856
    Abstract: Systems and methods for monitoring an operational state and/or a fill status of a drug container of a drug delivery device are provided. The drug container can hold a liquid drug. A plunger can be positioned within the drug container. A drive system can advance the plunger to expel the liquid drug from the container. A monitoring system can detect a movement and/or a position of the plunger and/or any component coupled to the plunger. The detection can enable determination of an amount of liquid drug that has been expelled and/or an amount of liquid drug remaining in the drug container. Dosing rates, flow rates, and dosage completion can also be determined.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: November 15, 2022
    Assignee: Insulet Corporation
    Inventors: David Nazzaro, Ian McLaughlin, Daniel Allis, Simon Kozin, Maureen McCaffrey
  • Publication number: 20220331521
    Abstract: A wearable drug delivery device that can deliver a liquid drug stored in a container to a patient is provided. The container can be a prefilled cartridge that can be loaded into the drug delivery device by the patient or that can be preloaded within the drug delivery device when provided to the patient. A sealed end of the container is pierced to couple the stored liquid drug to a needle conduit that is coupled to a needle insertion component that provides access to the patient. A drive system of the drug delivery device can expel the liquid drug from the cartridge to the patient through the needle conduit. The drive system can be controlled to provide the liquid drug to the patient in a single dose or over multiple doses.
    Type: Application
    Filed: July 1, 2022
    Publication date: October 20, 2022
    Inventors: David NAZZARO, Ian MCLAUGHLIN, Maureen MCCAFFREY, Simon KOZIN, Jackie MAC
  • Patent number: D1043666
    Type: Grant
    Filed: March 28, 2022
    Date of Patent: September 24, 2024
    Assignee: Apple Inc.
    Inventors: Jody Akana, Bartley K. Andre, Shota Aoyagi, Anthony Michael Ashcroft, Jeremy Bataillou, Brad G. Boozer, Makiko Kawamura Brzezinski, Tyler Scott Bushnell, Daniel J. Coster, Daniele De Iuliis, Colin Ely, M. Evans Hankey, Phillip M. Hobson, Julian Hoenig, Richard P. Howarth, Jonathan P. Ive, Eric Steven Jol, Benjamin Jordan Kallman, Duncan Robert Kerr, David Nazzaro, Trevor Jordan Ness, Marc A. Newson, David Pelletier, Matthew Dean Rohrbach, Fletcher Rothkopf, Peter Russell-Clarke, Jason Christopher Sauers, Benjamin Andrew Shaffer, Anna-Katrina Shedletsky, Mikael Silvanto, Christopher J. Stringer, Samuel Bruce Weiss, Christopher M. Werner, Eugene Antony Whang, Michael Benjamin Wittenberg, Stephen Paul Zadesky, Rico Zörkendörfer