Abstract: Rotary microfluidic medical pump and pumping method embodiments are discussed herein that may include elements having an integrated set for establishing fluid communication with a patient's body. Such embodiments may be used for controlled delivery of small and precise volumes of therapeutic or non-therapeutic medical fluids to a patient in a variety of environmental conditions.

Abstract: A method of preparing a bioprocess solution includes producing a mixture of liquid and air by hydrating a powder separating the liquid from the air by providing the mixture to a first filter capsule and allowing the liquid to flow to an outlet across a hydrophilic membrane of the first filter capsule while directing the air upwards along the first filter capsule toward a second filter capsule arranged above the first filter capsule, and venting the air from the second filter capsule by allowing the air to flow through a hydrophobic membrane of the second filter capsule.

Abstract: A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.

Abstract: An automated bioprocess solution preparation apparatus includes a first mixing chamber containing at least one ingredient for a bioprocess solution, a first port and a second port for a fluid to enter the mixing chamber, and a third port for a liquid bioprocess solution to exit the mixing chamber. The apparatus further includes an array of tubing for fluid flow within the apparatus, a sensor arranged to measure a property of the liquid bioprocess solution exiting the mixing chamber, a first valve associated with the first port, and a second valve associated with the second port. When the property meets or exceeds a threshold value, the apparatus is operable to perform at least one of: closing the first valve to block the fluid from entering the mixing chamber through the first port, and opening the second valve for the fluid to enter the mixing chamber through the second port.

Abstract: An automated bioprocess solution preparation apparatus includes a first mixing chamber containing at least one ingredient for a bioprocess solution, a first port and a second port for a fluid to enter the mixing chamber, and a third port for a liquid bioprocess solution to exit the mixing chamber. The apparatus further includes an array of tubing for fluid flow within the apparatus, a sensor arranged to measure a property of the liquid bioprocess solution exiting the mixing chamber, a first valve associated with the first port, and a second valve associated with the second port. When the property meets or exceeds a threshold value, the apparatus is operable to perform at least one of: closing the first valve to block the fluid from entering the mixing chamber through the first port, and opening the second valve for the fluid to enter the mixing chamber through the second port.

Abstract: An automated apparatus for preparing a liquid bioprocess solution includes at least one mixing chamber having a lower port and an upper port for fluid to enter the at least one mixing chamber, an array of tubing for fluid flow within the system, a plurality of valves provided within the tubing, and a mixing controller configured to cause the automated apparatus to perform a series of sequential mixing steps causing the preparation of the liquid bioprocess solution from a dry ingredient. The series of sequential mixing steps include opening a first valve associated with the lower port to provide fluid to the at least one mixing chamber through the lower port, and after a predetermined amount of elapsed time, closing the first valve and opening a second valve associated with the upper port to provide fluid to the at least one mixing chamber through the upper port.

Abstract: A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.

Abstract: A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.

Abstract: Rotary microfluidic medical pump and pumping method embodiments are discussed herein that may be used for controlled delivery of small and precise volumes of therapeutic or non-therapeutic fluids in a variety of environmental conditions. Certain medical pump and pumping method embodiments discussed herein may also include pump systems having a plurality of reservoirs and which are configured for pumping a plurality of fluids such as medicaments via a common pump mechanism and outlet tubing.

Abstract: A portable system and method for infusing fluid medicaments to a patient through an elastomeric fluid channel includes an airtight pressure shell for holding a collapsible bag of the fluid medicament to be infused. A pressure sensor connected to the pressure shell monitors decreases below ambient pressure inside the shell to determine when the ambient pressure becomes insufficient to continue assisting the withdrawal of fluid from the collapsible bag, to an external pinch/squeeze unit. At this point, an equilibrator operates to reestablish ambient pressure in the pressure shell for continued operation. In operation, the pinch/squeeze unit exerts radial forces on the elastomeric fluid channel. These forces act to sequentially push fluid medicament for infusion to the patient when the elastomeric fluid channel is occluded and stressed, and draw fluid medicament from the collapsible bag as the elastomeric fluid channel is unstressed.

Abstract: A portable system and method for infusing liquid medicaments to a patient through an elastomeric fluid channel includes an airtight pressure shell for holding a collapsible bag of the fluid medicament to be infused. A pressure sensor connected to the pressure shell monitors decreases below ambient pressure inside the shell to determine when the sub-ambient pressure becomes insufficient to continue assisting the withdrawal of fluid from the collapsible bag to an external pinch/squeeze unit. An equilibration valve is synchronized with the pinch/squeeze unit to reestablish ambient pressure in the pressure shell for continued operation as the pinch/squeeze unit acts to sequentially push liquid medicament for infusion into the patient.

Abstract: A device for infusing a medicament into a patient includes a disposable component having a collapsible reservoir for holding the medicament, a cannula, and an elastomeric tube connected in fluid communication between the reservoir and the cannula. A manipulator is mounted on a chassis for engagement with the elastomeric tube. The manipulator includes a piston and respective pinchers upstream and downstream from the piston for a close/open open/close changeover operation. In concert therewith, the piston cyclically advances and withdraws relative to a platen to thereby alternatingly dilate/constrict the tube section. When the upstream pincher is open, the piston withdraws to create a low fluid pressure, pLo, in the tube section to draw medicament into the tube. Alternately, when the downstream pincher is open, the piston is advanced to create a high fluid pressure, pHi, on the tube to infuse medicament into the patient.

Abstract: An automated apparatus for preparing a liquid bioprocess solution includes at least one mixing chamber having a lower port and an upper port for fluid to enter the at least one mixing chamber, an array of tubing for fluid flow within the system, a plurality of valves provided within the tubing, and a mixing controller configured to cause the automated apparatus to perform a series of sequential mixing steps causing the preparation of the liquid bioprocess solution from a dry ingredient. The series of sequential mixing steps include opening a first valve associated with the lower port to provide fluid to the at least one mixing chamber through the lower port, and after a predetermined amount of elapsed time, closing the first valve and opening a second valve associated with the upper port to provide fluid to the at least one mixing chamber through the upper port.

Abstract: A filter unit for a mixing apparatus includes a hydrophilic filter and a hydrophobic vent filter. The hydrophilic filter is configured to receive a fluid including a liquid and gas. The hydrophilic filter is further configured to sterilize the liquid. The hydrophobic vent filter is configured to receive the gas from the hydrophilic filter. The hydrophobic vent filter further includes a vent and a membrane configured to separate an interior of the filter unit from an exterior of the filter unit, the gas being vented from the filter unit by flowing across the membrane and out of the vent. In some embodiments, the filter unit further includes a defoaming device configured to receive gas, foam comprised the liquid containing trapped gas, and some of the liquid from the hydrophilic filter and is further configured to release at least some of the gas from the foam.

Abstract: An automated method includes providing a dry ingredient to be reconstituted into a liquid bioprocess solution and controlling, by a processing circuit, all automated system including at least one mixing chamber, an array of tubing for fluid flow within the system, and a plurality of valves provided within the tubing, to automatically prepare the liquid bioprocess solution from the dry ingredient. Controlling the auto system may include performing a series of sequential mixing steps, the series of sequential mixing steps causing the preparation of the liquid bioprocess solution. The method mixing include taking one or more measurements during the preparation of the liquid bioprocess solution, wherein each step is triggered by at least one of a measurement decreasing below, equaling, or exceeding a measurement threshold. Each step may also include opening or closing, by the processing circuit, at least one of the plurality of valves.

Abstract: Rotary microfluidic medical pump and pumping method embodiments are discussed herein that may be used for controlled delivery of small and precise volumes of therapeutic or non-therapeutic fluids in a variety of environmental conditions. Certain medical pump and pumping method embodiments discussed herein may also be useful for the controlled delivery of certain therapeutic fluids that may be susceptible to degradation when exposed to high levels of pressure, flow velocity, shear stress or the like.

Abstract: An oral care mouthpiece (10) is disclosed. The mouthpiece includes a shell (15) having an arch shape corresponding to a dental arch. The shell (15) includes a wall corresponding to facial surfaces of teeth in the dental arch, and a bite plate corresponding (157) to biting surfaces of the teeth. The mouthpiece also includes a wicking layer (19) on an inner surface of the wall. The mouthpiece further includes a filament layer (23) on the wicking layer.

Abstract: A dispenser for dispensing a liquid such as a tooth whitening gel can include a plunger and a housing having a first chamber that receives a first arm of the plunger and a second chamber that receives a second arm of the plunger. The housing can further include a first channel in fluid communication with the first chamber, a second channel in fluid communication with the second chamber, and a third channel formed at an intersection of the first and second channels. The housing can further include a static mixer than mixes a first liquid from the first chamber with a second liquid from the second chamber. The plunger may be disposed along a first axis and the third channel may be disposed along a second axis that intersects the first axis at an angle of between 10° and 170°.

Abstract: An oral care mouthpiece (10) is disclosed. The mouthpiece includes a shell (15) having an arch shape corresponding to a dental arch. The shell (15) includes a wall corresponding to facial surfaces of teeth in the dental arch, and a bite plate corresponding (157) to biting surfaces of the teeth. The mouthpiece also includes a wicking layer (19) on an inner surface of the wall. The mouthpiece further includes a filament layer (23) on the wicking layer.

Abstract: A dispenser for dispensing a liquid such as a tooth whitening gel can include a plunger and a housing having a first chamber that receives a first arm of the plunger and a second chamber that receives a second arm of the plunger. The housing can further include a first channel in fluid communication with the first chamber, a second channel in fluid communication with the second chamber, and a third channel formed at an intersection of the first and second channels. The housing can further include a static mixer than mixes a first liquid from the first chamber with a second liquid from the second chamber. The plunger may be disposed along a first axis and the third channel may be disposed along a second axis that intersects the first axis at an angle of between 10° and 170°.