Abstract: Disclosed herein is a technology to perform programmable RNA editing at single-nucleotide resolution using RNA-targeting CRISPR/Cas9. This approach, which Applicants have termed “Cas9-directed RNA editing” or “CREDIT,” provides a means to reversibly alter genetic information in a temporal manner, unlike traditional CRISPR/Cas9 driven genomic engineering which relies on permanently altering DNA sequence.

Abstract: Disclosed herein is a technology to perform programmable RNA editing at single-nucleotide resolution using RNA-targeting CRISPR/Cas9. This approach, which Applicants have termed “Cas9-directed RNA editing” or “CREDIT,” provides a means to reversibly alter genetic information in a temporal manner, unlike traditional CRISPR/Cas9 driven genomic engineering which relies on permanently altering DNA sequence.

Abstract: Disclosed herein is a technology to perform programmable RNA editing at single-nucleotide resolution using RNA-targeting CRISPR/Cas9. This approach, which Applicants have termed “Cas9-directed RNA editing” or “CREDIT,” provides a means to reversibly alter genetic information in a temporal manner, unlike traditional CRISPR/Cas9 driven genomic engineering which relies on permanently altering DNA sequence.

Abstract: Disclosed herein is a technology to perform programmable RNA editing at single-nucleotide resolution using RNA-targeting CRISPR/Cas9. This approach, which Applicants have termed “Cas9-directed RNA editing” or “CREDIT,” provides a means to reversibly alter genetic information in a temporal manner, unlike traditional CRISPR/Cas9 driven genomic engineering which relies on permanently altering DNA sequence.

Abstract: The disclosure relates to a method for operating an inertial sensor of a vehicle, in particular a motor vehicle, wherein measurement data of at least one measurement variable of the inertial sensor are captured during operation of the vehicle and are checked for error values in order to calibrate the inertial sensor. According to the disclosure, during operation of the vehicle, measurement data of a different measurement variable, which, however, correlates with the measurement variable of the inertial sensor, are captured by means of a reference sensor and are compared with the measurement data of the inertial sensor in order to record the error values in accordance with a deviation of the measurement data of the inertial sensor from the measurement data of the reference sensor.

Abstract: A method for the simultaneous graphical display of paths of optical wavelength channels in a telecommunications network together with one or more channel attributes is provided. The graphical display of the network also shows the direction of data flow transported by the channels. An audible or visual alarm for an error condition for a channel attribute on a link in the network can be produced if requires. The operator can also obtain detailed information on a channel by positioning the mouse over a channel.