Abstract: Cascaded active disturbance rejection control (ADRC) controllers are used in place of proportional-integral-derivative (PID) controllers for control of multiple plants comprising a facility, thereby achieving high stabilization across the facility. This configuration substantially damps cross-talk between systems, and yields consistent control of perturbations to the plants. Cascaded ADRC controllers can yield less waste, greater efficiency, less wear and tear on physical equipment, a higher quality product, and/or improved time efficiency. PID controllers can be retrofitted with ADRC controllers in two or more related plants. Alternatively, ADRC controllers can be designed for implementation in newly instantiated facilities comprising at least two related plants where ADRC is selected at the outset for process control.