Abstract: The present invention provides methods and compositions for treating bladder cancer. In particular, the present invention provides a fusion protein comprising a toxin moiety that is linked to an epithelial growth factor (EGF) moiety. The toxin moiety and the EGF moiety can be linked optionally via a linker. Typically, the fusion protein is administered intravesically into the cancerous bladder.

Abstract: A housing has a dispensing outlet (400) and contains: a liquid supplier (7) for supplying liquid containing at least one volatile component to a liquid outlet (7a); an electric field provider (41, 42, 7) for causing liquid issuing from the liquid outlet to provide electrically charged droplets from which at least a part of the at least one volatile component evaporates to produce vapour; a collection receptacle (92) for collecting electrically charged droplets to inhibit the electrically charged droplets from passing through the dispensing outlet; an attraction electrode (91) for attracting electrically charged droplets into the collection receptacle (90); and a flow director (95) for directing vapour away from the collection receptacle (92) and towards the dispensing outlet (400).

Abstract: A server receives a request from a client to provide a price and/or time quote and transmits initial diagnostic questions. The server receives a response to the initial questions and generates a initial cost range and/or time range estimate quote based on weighting pre-assigned in a knowledge base to information included in the response. The weightings assigned to possible responses are based on analysis of historical data. The server transmits the initial cost and/or time estimate quote to the client. Further, the server may refine the initial cost range and/or time range estimate quote in response to a request. Refining may includes generating additional diagnostic questions, receiving a responses, generating a refined quote based on a weighting pre-associated in the knowledge base with information included in the responses, and transmitting the refined quote to the client. Refining the quote may be an iterative process.

Abstract: Consumable or dissolvable tablets are manufactured by supplying a liquid containing a biodissolvable carrier to an outlet; establishing an electric field between the outlet and a support surface to cause liquid issuing from the outlet to form at least one fiber or fibrils of the biodissolvable carrier which fiber or fibrils deposit(s) onto the surface to form a fiber web or mat; separating the web or mat into a plurality of individual tablets; and incorporating at least one active ingredient on or in the tablets.

Abstract: Users access a deployment environment utilizing a browser. The deployment environment automatically creates an application based on user input and then deploys the created application in response to an indication from a user. Deployment may include providing an automatically generated reference. When an application is accessed via a browser utilizing such a reference, the deployment environment may execute and deliver access to the referenced application. In some implementations, the deployment environment may allow the user to choose between a wizard and a development tool. The wizard may present a series of prompts that guide the user through a default template for designing an application, which is then automatically created based on the user's responses.

Abstract: A method of providing a droplet spray, includes supplying a liquid polymer formulation within which substantially inert particulate material is suspended to an outlet and subjecting liquid issuing from the outlet to an electric field that causes the liquid to break up into droplets.

Abstract: Methods are described of delivering biological material, which methods include the steps of providing a liquid formulation containing the biological material, supplying the liquid formulation to an outlet and subjecting liquid issuing from the outlet to an electrical field thereby causing electrohydrodynamic processing of the liquid without denaturing the biological material. In one example, the liquid formulation is provided by removing salts from a formulation containing biological material that does not denature in alcohol and then adding an alcohol to the formulation before supplying the liquid formulation to the outlet. An acid may be added to the liquid formulation before supplying the liquid formulation to the outlet.

Abstract: A method of manufacturing a dosage form is described wherein a liquid solution of a biologically compatible polymer containing a suspension of particulate material that is insoluble in the polymer is supplied to a liquid supply tube (2) having an outlet (2a) and an electrical field is established between the outlet (2a) and a surface (19) spaced from the outlet (2a) to cause liquid issuing from the outlet to form a jet which dries to form a polymer fibre containing particles of the particulate material and which deposits onto the surface (19) to form a dosage which consists of said particulate containing fibre which fibre dissolves or disintegrates in a wet environment such as the mouth.

Abstract: Disclosed is process for the production of catalyst coated membranes, and catalyst coated membranes having a first electrode that is visually more reflective than the second electrode. The catalyst coated membranes are useful in electrochemical cells, and especially in fuel cells.

Abstract: In one aspect the present invention relates to a method of expressing an immunotoxin in Pichia pastoris strain mutated to toxin resistance comprising a) growing the Pichia pastoris in a growth medium comprising an enzymatic digest of protein and yeast extract and maintaing a dissolved oxygen concentration at 40% and above; and b) performing methanol induction with a limited methanol feed of 0.5-0.75 ml/min/10 L of initial volume during induction along with a continuous inusion of yeast extract at a temperature below 17.5° C., antifoaming agent supplied up to 0.07%, agitation reduced to 400 RPM, and the induction phase extended out to 163 h.

Abstract: The invention provides a method of treating diabetes in a subject, comprising administering to the diabetic subject an immunotoxin, thereby reducing the subject's T-cell population, and administering to the subject pancreatic islet cells from a donor. The immune tolerance inducing treatment regimen, used optionally with adjunct immunosuppressive agents, prevents pancreatic islet cell rejection while maintaining long term islet cell function following xenogeneic and allogeneic pancreatic islet cell transplantation. Thus, the methods of the present invention provide a means for treating diabetes, wherein the need for exogenous insulin or immunosuppressive agents is decreased or eliminated. Also provided is a method of inhibiting a rejection response of a transplant recipient, comprising administering an immunotoxin during the peritransplant period, thereby transiently reducing the number of T-cell lymphocytes and promoting long-term survival of the transplant.

Abstract: This invention relates to a slot die for forming a coating.

Abstract: An eye covering (700) for covering an exposed surface portion of an eye, the covering comprising a body having front and rear surfaces (702a and 701a) with the rear surface being shaped to conform to said exposed surface portion (701, 702) and at least a portion of the body comprising biologically compatible polymer fibre.

Abstract: A method of providing a droplet spray, includes supplying a liquid polymer formulation within which substantially inert particulate material is suspended to an outlet and subjecting liquid issuing from the outlet to an electric field that causes the liquid to break up into droplets.

Abstract: A method of manufacturing a dosage form is described wherein a liquid solution of a biologically compatible polymer containing a suspension of particulate material that is insoluble in the polymer is supplied to a liquid supply tube (2) having an outlet (2a) and an electrical field is established between the outlet (2a) and a surface (19) spaced from th outlet (2a) to cause liquid issuing from the outlet to form a jet which dries to form a polymer fibre containing particles of the particulate material and which deposits onto the surface (19) to form a dosage which consists of said particulate containing fibre which fibre dissolves or disintegrates in a wet environment such as the mouth.

Abstract: An inhaler has a housing containing a chamber (1a) providing a reservoir (8) for liquid providing an active ingredient to be supplied to a liquid outlet (10a). First and second electrodes are spaced apart (11 and 12) with the first electrode being provided at or adjacent the liquid outlet (10a). A voltage supply (5, 7) is activated in response to air flowing through an air inlet (30) of the housing to provide a potential difference between the first and second electrodes (11 and 12) to create an electric field for causing comminution of liquid issuing from the liquid supply outlet (10a) to produce a stream of electrically charged comminuted matter for supply to the nasal passages of a user via an outlet (4) of the housing.

Abstract: An inhaler has a housing containing a chamber (1a) providing a reservoir (8) for liquid providing an active ingredient to be supplied to a liquid outlet (10a). First and second electrodes are spaced apart (11 and 12) with the first electrode being spaced apart (11 and 12) with the first electrode being provided at or adjacent the liquid outlet (10a). A voltage supply (5, 7) is activated in response to air flowing through an air inlet (30) of the housing to provide a potential difference between the first and second electrodes (11 and 12) to create an electric field for causing comminution of liquid issuing from the liquid supply outlet (10a) to produce a stream of electrically charged comminuted matter for supply to the nasal passages of a user via an outlet (4) of the housing.

Abstract: Methods are described of delivering biological material, which methods include the steps of providing a liquid formulation containing the biological material, supplying the liquid formulation to an outlet and subjecting liquid issuing from the outlet to an electrical field thereby causing electrohydrodynamic processing of the liquid without denaturing the biological material. In one example, the liquid formulation is provided by removing salts from a formulation containing biological material that does not denature in alcohol and then adding an alcohol to the formulation before supplying the liquid formulation to the outlet. An acid may be added to the liquid formulation before supplying the liquid formulation to the outlet.