Abstract: A medicament preparation system includes a water purification module and a medicament proportioning module that is interoperable with a replaceable fluid circuit. The fluid circuit includes a purified water inlet, a product medicament outlet, and a plurality of pumping tube segments. At least a first concentrate container is connected by at least a portion of the fluid circuit to the product medicament output and a first concentration measurement sensor station is positioned in a flow path. A controller is programmed to calculate iteratively a concentration of a first concentrate from the first concentrate container and the purified water from a signal generated by the first concentration measurement sensor station and to regulate one or both of a first pumping actuator engaged with the first pumping tube segment and a second pumping actuator engaged with the second pumping tube segment, responsively to the concentration of the first concentrate and water.

Abstract: Techniques for performing conversation recovery of a system/user exchange are described. In response to determining that an action responsive to a user input cannot be performed, a system may determine a topic to recommend to a user. The topic may be unrelated to the original substance of the user input. The system may have access to various data representing a context in which a user provides an input to the system. The system may use these inputs and various data at runtime to make a determination regarding whether a user should be recommended a topic, as well as what that topic should be. The system may cause a question be output to the user, with the question asking the user about the topic, for example whether the user would like a song played, whether the user would like to hear information about a particular individual (e.g., artist), whether the user would like to know about a particular skill (e.g.

Abstract: Systems and related methods are provided for testing a student where particular problem solving skills of a student are identified and computer based lessons are formulated based on the student's particular failings and skills associated with the failings. The systems and related methods include generating and displaying an aptitude test with a list of questions on a graphical user interface on the display; creating or updating a record of the questions from the aptitude test; correlating failed results of the aptitude test with one or more skills; generating a plurality of lesson courses for the one or more skills; and generating and displaying the plurality of lesson courses on the graphical user interface.

Abstract: An operations platform includes a structure configured to house and transport drones and a storage facility configured to store the drones within the structure. The operations platform includes a lift or conveyor configured to move the plurality of drones to/from a launching area. In some implementations, the operations platform may also include at least one robotic element configured to move the drones to and from the storage facility.

Abstract: A system described herein may provide a technique for the generation of one or more models indicating positions and/or attributes of objects within an environment, such as a warehouse, a facility, a data center, etc. The models may be generated by measuring radio frequency (“RF”) metrics or other metrics within the environment over time. The environment may include mobile antenna apparatuses providing wireless coverage to wireless devices within the environment. The mobile antenna apparatuses may be moved within the environment based on the positions of objects within the environment (e.g., as indicated by the one or more models) and the positions of one or more wireless devices that connect to one or more of the mobile antenna apparatuses.

Abstract: A system described herein may provide a technique for the generation of one or more models indicating positions and/or attributes of objects within an environment, such as a warehouse, a facility, a data center, etc. The models may be generated by measuring radio frequency (“RF”) metrics or other metrics within the environment over time. The environment may include mobile antenna apparatuses providing wireless coverage to wireless devices within the environment. The mobile antenna apparatuses may be moved within the environment based on the positions of objects within the environment (e.g., as indicated by the one or more models) and the positions of one or more wireless devices that connect to one or more of the mobile antenna apparatuses.

Abstract: An operations platform includes a structure configured to house and transport drones and a storage facility configured to store the drones within the structure. The operations platform includes a lift or conveyor configured to move the plurality of drones to/from a launching area. In some implementations, the operations platform may also include at least one robotic element configured to move the drones to and from the storage facility.

Abstract: A system includes a storage facility configured to store drones. The system may also include at least one robotic element configured to move the drones to and from the storage facility and a conveyor configured to move the drones to a launching area. The at least one robotic element may include an articulating arm configured to move a first drone from the storage facility to the conveyor, in response to identifying that the first drone is selected for a flight.

Abstract: An assembly 10 for dispensing sanitiser fluid. The assembly 10 includes a post 12 having opposed ends 14, 16, a pedal 18 pivotally securable adjacent one of the ends 16 of the post 12, a platform 20 dimensioned to be received within the post 12, the platform 20 configured to support a reservoir containing the sanitiser fluid, an elongate member 22 dimensioned to extend between the pedal 18 and the platform 20 such that pivoting the pedal 18 moves the elongate member 22 to cause the platform 20 to be displaced along the post 12, a stop 24 securable to the post 12 to be operatively above the platform 20 such that, in use, the reservoir is urged against the stop 24 when the platform 20 is displaced to cause sanitiser fluid to be dispensed from the reservoir, and an open-topped receptacle 26 defining an internal space 28, the receptacle 26 securable to the post 12 to be operatively below the stop 24 to allow collecting dispensed fluid in the internal space 28.

Abstract: Techniques are disclosed for propagating a system level utilization goal to individual system elements. For example, a utilization goal such as a load factor goal for a group of airline flights in a given market segment and time period may be propagated to each flight in the group. When propagating a load factor goal to a group of airline flights, a goal value, historical load factors, and a capacity of each flight in the group may be used to determine a load factor target for each flight in the flight group. The propagated load factor targets are expected to be realizable by each flight in the flight group and, in the aggregate, satisfy the system level goal.

Abstract: Systems and methods for a user to receive dynamic business information on a wireless communication device via a wireless connection are presented. The wireless communication device can be a hand-held personal computer, a paging device, a wireless telephone, or other wireless communication device. Dynamic business information comprising subscription-based content that is tailored to an individual is delivered to the device. The systems and methods provide a mechanism for setting personalized thresholds for data items maintained by an application. These thresholds can then be used to enact an event (or alert) via the application when the threshold is met. For example, the alert can be an audible sound or a display of a message that appears on the wireless communication device. As a further example, the alert can comprise an e-mail received on the wireless communication device.

Abstract: The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R1 and R2 are independently hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR4 and O, O and CR?4 and NR?4 and N, where the unsaturation is in the appropriate place in the ring, and where one of R3 and R4 or R?4 is an optionally substituted C3-20 heteroaryl or C5-20 aryl group, and the other of R3 and R4 or R?4 is H, or R3 and R4 or R?4 together are -A-B—, which collectively represent a fused optionally substituted aromatic ring. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.

Abstract: A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(?O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3 or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(?O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, o

Abstract: A compound of formula (I): and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, and their use in treating diseases ameliorated by the inhibition of ATM.

Abstract: Compounds of formula I: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; the dotted lines represent two double bonds in the appropriate locations; and where Z is selected from S, O, C(?O), CH2 and NH are disclosed for use in inhibiting DNA-PK.

Abstract: Compounds of formula l: wherein A, B and D are respectively selected from the group consisting of: (i) CH, NH, C; (ii) CH, N, N;and (iii) CH, O, C; are disclosed for use in inhibiting DNA-PK.

Abstract: A compound of formula I: and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein: R1 and R2 are independently selected from hydrogen, an optionally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; Q is —NH—C(?O)— or —O—; Y is an optionally substituted C1-5 alkylene group; X is selected from SR3 or NR4R5, wherein, R3, or R4 and R5 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl groups, or R4 and R5 may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; if Q is —O—, X is additionally selected from —C(?O)—NR6R7, wherein R6 and R7 are independently selected from hydrogen, optionally substituted C1-7 alkyl, C5-20 aryl, or C3-20 heterocyclyl g

Abstract: The present invention provides compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, wherein R1 and R2 are independently hydrogen, an option ally substituted C1-7 alkyl group, C3-20 heterocyclyl group, or C5-20 aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; and R3 is an optionally substituted C3-20 heterocyclyl or C5-20 aryl group, and their use as pharmaceuticals, particularly in treating diseases which are retroviral mediated or ameliorated by the inhibition of DNA-PK,

Abstract: An imager, including: a semiconductor substrate; a plurality of spaced image pixels formed in the substrate; and a dielectric layer formed over the image pixels, the dielectric layer having a top surface. The imager further includes a plurality of depressions formed in the top surface; and a plurality of lenses having top surfaces, each lens formed in the depression corresponding to an underlying image pixel, the top surface of each lens being optically planar with the top surface of the dielectric.

Abstract: A method of making an imager including the steps of providing a semiconductor substrate; forming a plurality of spaced image pixels in the substrate; depositing a dielectric layer over the image pixels and making this layer optically planar by chemical mechanical polishing, thereby forming an optically flat surface. The method further includes forming a plurality of depressions in the optically flat surface; uniformly depositing a lens material on the optically flat surface, entirely filling the depressions; and forming the lens material.