Abstract: An image sensor includes a substrate; a plurality of pixels on the substrate, one or more of the pixels comprises (i) first and second charge-storage regions having at least one photosensitive area; (ii) a lateral overflow drain; (iii) a first lateral overflow gate adjacent the first charge-storage regions that passes substantially all charges from the first charge-storage region to the lateral overflow drain; and (iv) a second lateral gate adjacent the second charge-storage region that passes excess photo-generated charge into the lateral overflow drain for blooming control.

Abstract: A charge coupled device includes a substrate; a plurality of image pixels arranged in a two dimensional array in the substrate for capturing an electronic representation of an image and for transferring charge in a first direction; a transfer mechanism for transferring charge in a second direction from the plurality of the image pixels for further processing; an amplifier structure disposed in the substrate that receives the charge from the transfer mechanism and converts the charge into a voltage signal; a first opaque layer spanning over the amplifier for blocking near-infrared light inherently generated by an electrical field within the amplifier structure when a voltage is applied; and a second opaque layer deposited into the substrate for also blocking near-infrared light inherently generated by an electrical field within the amplifier structure when a voltage is applied.

Abstract: A device for securing a spinal rod to a spine includes a head adapted to secure the spinal rod, and a locking cap adapted to engage the head and the spinal rod, the locking cap having an unlocked position, an intermediate position, and a locked position. A method of securing the spinal rod to the device includes aligning the spinal rod to a desired position relative to the spine with the locking cap in the unlocked position.

Abstract: An interline transfer type image sensing device that can be operated at high speed and with low image smear is described. The device incorporates a refractory metal layer which is used for both a light shield over the vertical charge transfer region and as a wiring layer for low resistance strapping of poly crystalline silicon (polysilicon) gate electrodes for the vertical charge transfer region. Plugs provided by a separate metallization layer connect the refractory light shield to the polysilicon gate electrode. These plugs allow high temperature processing after refractory light shield patterning for improved sensor performance without degradation of the polysilicon gate electrode or the refractory lightshield layer.

Abstract: An image sensor includes a substrate having photosensitive areas; an insulator spanning the substrate; and a first and second layer of a multi-layer metallization structure, wherein the first layer forms light shield regions over selected portions of the photosensitive area as well forming circuit interconnections and barrier regions to prevent spiking into the substrate or gates at contacts in the non-imaging area; and the second layer spanning the interconnections and barrier regions of the first layer only over the non-imaging areas and the second layer overlays edges of the first layer.

Abstract: The present invention relates to the treatment of dopamine-related dysfunction using full D1 dopamine receptor agonists in an intermittent dosing protocol with a short, but essential, “off-period.” The D1 agonist concentration is reduced during the “off-period” to obtain a plasma concentration of agonist that suboptimally activates D1 dopamine receptors for a period of time to prevent induction of tolerance. Specifically, the method comprises the steps of periodically administering to a patient a full D1 agonist with a half-life of up to about 6 hours at a dose resulting in a first plasma concentration of agonist capable of activating D1 dopamine receptors to produce a therapeutic effect. The dose is reduced at least once every 24 hours to obtain a second lower plasma concentration of agonist that results in suboptimal activation of D1 dopamine receptors for a period of time sufficient to prevent induction of tolerance.

Abstract: An apparatus is disclosed for connecting first and second elongated spaced apart spinal rods to one another which includes an elongated body portion, a clamp portion depending from the body portion for engaging a spinal rod, the clamp portion defining a deformable clamp body having opposed clamp arms configured for movement between a first position wherein a spinal rod is received between the opposed clamp arms of the clamp body and a second position wherein the spinal rod is securely engaged by the opposed clamp &ms &the clamp body, and structure operatively associated with the clamp body which h configured to effectuate movement of the opposed clamp arms of the clamp body between the first and second positions.

Abstract: A method for facilitating fusion of bone structures includes providing an implant member for positioning between opposed bone structures, the implant member having a first end and a second end, and a segmentable portion having an outer wall defining an internal cavity for reception of bone growth inducing substances. The outer wall has at least one groove which extends substantially continuously about the outer wall to define a plurality of discrete ring-like segments. Each ring-like segment includes a plurality of apertures extending therethrough in communication with the internal cavity to permit fusion of vertebral bone tissue. The vertebral space defined between adjacent vertebral bodies is accessed, and the desired implant member length for insertion into the space between adjacent vertebral bodies is determined. The implant member is cut to the desired length and advanced within the vertebral space between the adjacent vertebral bodies.

Abstract: A method of determining an integral of a function over an n-dimensional integration domain from the values of the function at a plurality of discrete data points within the integration domain, comprises partitioning the integration domain into a plurality of k-dimensional simplexes, where k?n. The function is integrated over each simplex, and the results are summed. The method may be applied in the processing of geophysical data such as, for example, seismic data, where the function is a function of at least the geophysical data. The processed data may then be used to obtain information about the physical properties of the earth's interior.

Abstract: A fusion implant apparatus for facilitating fusion of bone structures includes an implant member for positioning between opposed bone structures having a first ring-like segment and a second ring-like segment which engage one another in an end-to-end manner. Each ring-like segment includes an outer wall which defines an internal cavity for the reception of bone growth inducing substances. Each ring-like segment also includes a plurality of apertures which extend through the outer wall of the ring-like segments in communication with the internal cavity to permit fusion of vertebral bone tissue. The first ring-like segment includes first and second mechanical interfaces. The first mechanical interface is dimensioned to engage a corresponding mechanical interface disposed on the second ring-like segment and the second mechanical interface is dimensioned to mechanically engage an end cap.

Abstract: The present invention provides methods and systems for making measurements associated with a rock formation including a main borehole, a microborehole extending from the main borehole into the rock formation, and one or more sensing devices positioned and arranged to make a measurement at measurement zones being located in the microborehole. A packer can also be installed in the microborehole dimensioned and arranged to hydraulically isolate the measurement zones from conditions present in other parts of the microborehole and/or main borehole. Methods and systems are also provided for taking fluid samples and injecting fluid tracers in a microborehole.

Abstract: An image sensor includes a plurality of photosensitive sites which convert incident light into a charge for forming a bounded array of active imaging pixels; one or more substitutional pixels sites arranged in predetermined locations and interspersed amongst the boundary of the array of active imaging pixels; wherein the substitutional pixels are of a different design from the active imaging pixels which provides data, information or function different from the active pixels for improving performance, operation, manufacture, and/or assembly of the image sensor.

Abstract: A pair of lever arms each have an intermediate segment configured for pivotal mounting on a pair of pins that support a corresponding end of a pair of mounting arms of a flapper valve. Each of the lever arms has a forward end configured to engage and provide a lifting force on a corresponding one of the flapper valve mounting arms when the lever arm and the flapper valve mounting arm are rotated in a first direction during opening of the flapper valve upon manual actuation of a flush control lever or button. A counterweight reservoir is connected to a pair of rearward ends of the lever arms for holding a volume of water and delays rotation of the flapper valve in a reverse direction to seal the flush valve until a volume of water has drained through an outlet aperture in a bottom portion of the counterweight reservoir.

Abstract: Novel dopamine receptor ligands of the formula: pharmaceutical formulations of such compounds, and a method using such compounds for treating a patient suffering from dopamine-related dysfunction of the central or peripheral nervous system, are described. The compounds are expected to be useful in treating Parkinson's disease, improving cognition, improving memory, improving the negative symptoms of schizophrenia, improving attention-deficit hyperactivity disorder and related developmental disorders, treating substance abuse disorders, and in treating various peripheral conditions where changes in dopamine receptor occupation affects physiological function, including organ perfusion, cardiovascular function, and selected endocrine and immune system functions.

Abstract: An apparatus is disclosed for connecting first and second elongated spaced apart spinal rods to one another which includes an elongated body portion, a clamp portion depending from the body portion for engaging a spinal rod, the clamp portion defining a deformable clamp body having opposed clamp arms configured for movement between a first position wherein a spinal rod is received between the opposed clamp arms of the clamp body and a second position wherein the spinal rod is securely engaged by the opposed clamp arms of the clamp body, and structure operatively associated with the clamp body which is configured to effectuate movement of the opposed clamp arms of the clamp body between the first and second positions.

Abstract: Provided is a method, system and software for facilitating transfer of authorized use of a telephone number from a first user to a second user, including receiving an offer to sell from the first user, transmitting the offer to sell to the second user, receiving an offer to buy from the second user, transmitting the offer to buy to the first user, receiving a request from the first user to have the authorized use of the telephone number transferred to the second user, and transmitting the request to a telephone carrier. Also included are methods, systems and software for presenting advertisements to users and charging users and advertisers fees.

Abstract: An image sensor generates an image signal with a differential response to image light. The image sensor has an array of photosites divided into standard photosites and non-standard photosites. A limiter provides the standard photosites with a predetermined standard response to a light exposure and the non-standard photosites with a predetermined slower response to the same light exposure. The standard photosites and nonstandard photosites both sparsely sample the array in a predetermined pattern.

Abstract: An image sensor includes an image sensing portion for receiving incident light that is converted to a plurality of charge packets; a transfer mechanism for transferring the charge packets from the image sensing portion; and an output structure that receives the charge packets from the transfer mechanism for transporting output signals from the image sensor, wherein the output structure comprises a transparent conductor for a gate electrode gate.

Abstract: Instruments and methods for inserting an intervertebral implant. Insertion of the implant is accomplished by grasping the implant between the arms of an insertion instrument having arms which separate from each other and close against each other onto the implant, such that the ends of the arms of the insertion instrument engage recesses of the implant. A spacer may be provided between the arms of the insertion instrument to help position the implant while held by the arms.