Patents by Inventor David Nigel Hurst

David Nigel Hurst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Oxadiazole derivatives active on sphingosine-1-phosphate (S1P)
    Patent number: 8222245
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: July 17, 2012
    Assignee: Glaxo Group Limited
    Inventors: Emmanuel Hubert Demont, Jag Paul Heer, John Skidmore, Ian David Wall, Jason Witherington, Thomas Daniel Heightman, David Nigel Hurst, Christopher Norbert Johnson
  • OXADIAZOLE DERIVATIVES ACTIVE ON SPHINGOSINE-1-PHOSPHATE (SIP)
    Publication number: 20100273771
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: December 19, 2008
    Publication date: October 28, 2010
    Inventors: Emmanuel Hubert Demont, Jag Paul Heer, John Skidmore, Ian David Wall, Jason Witherington, Thomas Daniel Heightman, David Nigel Hurst, Christopher Norbert Johnson
  • 1, 2, 4 -OXADIAZOLE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASES
    Publication number: 20100273770
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: December 19, 2008
    Publication date: October 28, 2010
    Inventors: Jag Paul Heer, Thomas Daniel Heightman, David Nigel Hurst, Christopher Norbert Johnson, John Skidmore, Ian David Wall
  • COMPOUNDS
    Publication number: 20100174065
    Abstract: The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
    Type: Application
    Filed: January 28, 2009
    Publication date: July 8, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Jag Paul HEER, Thomas Daniel HEIGHTMAN, David Nigel HURST, Christopher Norbert JOHNSON, John SKIDMORE, Ian David WALL
  • Pyridine Compounds For The Treatment Of Prostaglandin Mediated Diseases
    Publication number: 20100137378
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein X, Y, Z, R2a, R2b, R3a, R3b, R8, R9, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine (EP, —receptor antagonists).
    Type: Application
    Filed: December 21, 2005
    Publication date: June 3, 2010
    Applicant: GLAXO GROUP LIMITED
    Inventors: Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Derek Anthony Rawlings, Tiziana Scoccitti
  • Cyclopropyl aryl amide derivatives and uses thereof
    Patent number: 7723391
    Abstract: Compounds of the formula: wherein Ar1, Ar2, R1 and R2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
    Type: Grant
    Filed: October 2, 2008
    Date of Patent: May 25, 2010
    Assignee: Roche Palo Alto LLC
    Inventors: Daisy Joe Du Bois, David Garrett Loughhead, Hans Maag, Jason Manka, David Bernard Smith, David Nigel Hurst
  • BENZOFURAN COMPOUNDS USEFUL IN THE TREATMENT OF CONDITIONS MEDIATED BY THE ACTION OF PGE2 AT THE EP1 RECEPTOR
    Publication number: 20100056527
    Abstract: A compound of formula (I): wherein R1, R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: February 14, 2008
    Publication date: March 4, 2010
    Inventors: Andrew John Eatherton, Gerard Martin Paul Giblin, Mairi Gibson, Adrian Hall, David Nigel Hurst
  • Indole Compounds
    Publication number: 20100016371
    Abstract: The present application relates to compounds of formula (I) or a pharmaceutically acceptable derivative thereof; wherein X, R1, R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: July 9, 2007
    Publication date: January 21, 2010
    Applicant: Glaxo Group Limited
    Inventors: Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Tiziana Scoccitti, Pamela Joan Theobald
  • Indole Compounds
    Publication number: 20090298866
    Abstract: The present application relates to compounds of formula (I) or a pharmaceutically acceptable derivative thereof: formula (I) wherein X, R1, R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: July 9, 2007
    Publication date: December 3, 2009
    Inventors: Adrian Hall, David Nigel Hurst, Tiziana Scoccitti, Pamela Joan Theobald
  • PYRAZOLE COMPOUNDS AS PROSTAGLANDIN RECEPTORS LIGANDS
    Publication number: 20090239845
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein Z, R1, R2a, R2b, R10, R11 and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: April 24, 2006
    Publication date: September 24, 2009
    Inventors: Elizabeth Ann Conway, Gerard Martin Paul Giblin, Mairi Gibson, Adrian Hall, Thomas George Christopher Hayhow, Mark Patrick Healy, David Nigel Hurst, Ian Reginald Kilford, Stephen Carl McKeown, Alan Naylor, Helen Susanne Price, Derek Anthony Rawlings
  • Cyclopentene compounds
    Publication number: 20090227591
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, B, Z, R1, R2a, R2b, R8, R9, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: October 6, 2004
    Publication date: September 10, 2009
    Inventors: Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Xiao Qing Lewell, Alan Naylor, Riccardo Novelli
  • Benzofuran Compounds As EP1 Receptor Antagonists
    Publication number: 20090099169
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein R1, R2a, R2b, R2c, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: April 3, 2007
    Publication date: April 16, 2009
    Applicant: GLAXO GROUP LIMITED
    Inventors: Mairi Gibson, Adrian Hall, David Nigel Hurst, Derek Anthony Rawlings
  • PYRIDYL COMPOUNDS
    Publication number: 20090099177
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein R1, and R2, and R3 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: May 2, 2007
    Publication date: April 16, 2009
    Inventors: Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Tiziana Scoccitti
  • Cyclopropyl aryl amide derivatives and uses thereof
    Publication number: 20090093525
    Abstract: Compounds of the formula: wherein Ar1, Ar2, R1 and R2 are as defined herein. Also provided are pharmaceutical compositions, methods of using, and methods of preparing the subject compounds.
    Type: Application
    Filed: October 2, 2008
    Publication date: April 9, 2009
    Inventors: Daisy Joe Du Bois, David Garrett Loughhead, Hans Maag, Jason Manka, David Bernard Smith, David Nigel Hurst
  • Furan Compounds Useful As Ep1 Receptor Antagonists
    Publication number: 20080287430
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof wherein X, Z, R1, R2a, R2b, R3, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: April 24, 2006
    Publication date: November 20, 2008
    Inventors: Rino Antonio Bit, Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Tiziana Scoccitti
  • Phenyl compounds
    Patent number: 7446222
    Abstract: Compounds of formula (I) or derivatives thereof: wherein A, B, Z, R1, R2a, R2b, Rx, R8, and R9 are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Grant
    Filed: October 30, 2003
    Date of Patent: November 4, 2008
    Assignee: Glaxo Group Limited
    Inventors: Rino Antonio Bit, Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Neil Derek Miller, Tiziana Scoccitti
  • Cyclohexene Compounds
    Publication number: 20080234335
    Abstract: Compounds of formula (I) wherein A, B, Z, R1, R2a, R2b, R8, R9 and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: October 6, 2004
    Publication date: September 25, 2008
    Inventors: Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst
  • Oxazole and Thiazole Compounds and Their Use in the Treatment of Pge2 Mediated Disorders
    Publication number: 20080207708
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein X, Z, Y?, Y?, R1, R2a, R2b, and Rx are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Application
    Filed: April 24, 2006
    Publication date: August 28, 2008
    Applicant: GLAXO GROUP LIMITED
    Inventors: Rino Antonio Bit, Adrian Hall, David Nigel Hurst, Tiziana Scoccitti
  • (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives
    Patent number: 7232821
    Abstract: Compounds of formula (I) or a pharmaceutically acceptable derivative thereof: wherein A, R1, R2, Rx, R8, R9 and n are as defined in the specification, a process for the preparation of such compounds, pharmaceutical compositions comprising such compounds and the use of such compounds in medicine.
    Type: Grant
    Filed: April 7, 2003
    Date of Patent: June 19, 2007
    Assignee: Glaxo Group Limited
    Inventors: Gerard Martin Paul Giblin, Adrian Hall, David Nigel Hurst, Ian Reginald Kilford, Xiao Qing Lewell, Alan Naylor, Riccardo Novelli
  • Oxamide IMPDH inhibitors
    Patent number: 6867299
    Abstract: Disclosed are compounds of the general formula which are oxamide derivatives and inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH).
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: March 15, 2005
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael John Broadhurst, Christopher Huw Hill, David Nigel Hurst, Philip Stephen Jones, Paul Brittain Kay, Ian Reginald Kilford, Robert Murray McKinnell