Patents by Inventor David Nilson
David Nilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220260525Abstract: A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.Type: ApplicationFiled: December 23, 2021Publication date: August 18, 2022Applicant: ProteinSimpleInventors: Joshua I. MOLHO, Kelly GARDNER, Danh C. TRAN, Eric JABART, David NILSON, Yuri KOUCHNIR, Michael HUSTON, Colin B. KENNEDY, David John ROACH
-
Patent number: 11237131Abstract: A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.Type: GrantFiled: May 20, 2016Date of Patent: February 1, 2022Assignee: ProteinSimpleInventors: Joshua I. Molho, Kelly Gardner, Danh C. Tran, Eric Jabart, David Nilson, Yuri Kouchnir, Michael Huston, Colin B. Kennedy, David John Roach
-
Publication number: 20160370319Abstract: A system for assaying a biological sample for a presence of a target analyte includes an assaying device and a computer controller. The assaying device includes a housing, a receptacle disposed in the housing, and a source of activation energy. The receptacle is configured to accept an electrophoresis cell. The electrophoresis cell has a recess area configured to accept a chip configured to accept the biological sample. The chip includes a polymeric separation medium with activatable functional groups that covalently bond to the target analyte when activated. The source of activation energy is configured to supply activation energy to activate the activatable functional groups. The computer controller is operably coupled to the source of activation energy and is configured to activate the source of activation energy to direct an application of activation energy to the polymeric separation medium to activate the activatable functional groups.Type: ApplicationFiled: May 20, 2016Publication date: December 22, 2016Inventors: Joshua I. Molho, Kelly Gardner, Danh C. Tran, Eric Jabart, David Nilson, Yuri Kouchnir, Michael Huston, Colin B. Kennedy, David John Roach
-
Patent number: 9008758Abstract: The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.Type: GrantFiled: December 23, 2010Date of Patent: April 14, 2015Assignee: Xenogen CorporationInventors: Michael D. Cable, Bradley W. Rice, David Nilson
-
Patent number: 8279334Abstract: The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.Type: GrantFiled: October 11, 2007Date of Patent: October 2, 2012Assignee: Xenogen CorporationInventors: David Nilson, Michael D. Cable, Bradley W. Rice, Kevin Kearney
-
Publication number: 20110092813Abstract: The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.Type: ApplicationFiled: December 23, 2010Publication date: April 21, 2011Applicant: XENOGEN CORPORATIONInventors: Michael D. Cable, Bradley W. Rice, David Nilson
-
Patent number: 7881773Abstract: The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.Type: GrantFiled: July 12, 2006Date of Patent: February 1, 2011Assignee: Xenogen CorporationInventors: Michael D. Cable, Bradley W. Rice, David Nilson
-
Patent number: 7813782Abstract: The invention described herein provides systems and methods for handling objects within an imaging system, such as a multi-modal imaging system. An object handling system operates to position an object to be imaged in an interior cavity of a light imaging system, and also moves the object to be imaged between the light imaging system and a second imaging system. The object handling system can include components such as a stage that supports the object, a manipulator configured to move the stage between the interior and exterior of the light imaging system and a light seal configured to interface with a light seal on an exterior wall of the light imaging system.Type: GrantFiled: July 12, 2006Date of Patent: October 12, 2010Assignee: Xenogen CorporationInventors: Michael D. Cable, Bradley W. Rice, David Nilson
-
Patent number: 7595838Abstract: Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a processor. Structured light images obtained from one or more views within the imaging box may be used to build a structured light representations of the sample.Type: GrantFiled: July 12, 2006Date of Patent: September 29, 2009Assignee: Xenogen CorporationInventors: David Nilson, Michael D. Cable, Bradley W. Rice
-
Patent number: 7589786Abstract: Systems and methods are provided for taking images of a sample. The sample is placed in an imaging box comprising a moveable stage that allows images of the sample to be taken from various positions and angles within the imaging box. The images are taken by a camera and sent to a processor. Structured light images obtained from one or more views within the imaging box may be used to build a structured light representations of the sample.Type: GrantFiled: July 12, 2006Date of Patent: September 15, 2009Assignee: Xenogen CorporationInventors: David Nilson, Michael D. Cable, Bradley W. Rice
-
Patent number: 7474398Abstract: A fluorescence illumination system is provided for use with an imaging apparatus that defines a light-tight imaging compartment. The fluorescence illumination system includes a trans-illumination component configured to direct excitation light into a first surface of the specimen wherein diffused light emanates from a second surface thereof for receipt through the view port to acquire fluorescence data of the specimen. Further, the fluorescence illumination system includes an epi-illumination component configured to direct excitation light onto a third surface of the specimen wherein the diffused light exits the third surface thereof for receipt through the view port to acquire fluorescence data of the specimen.Type: GrantFiled: May 15, 2006Date of Patent: January 6, 2009Assignee: Xenogen CorporationInventors: David Nilson, Brad Rice, Tamara Troy
-
Patent number: 7474399Abstract: A dual illumination system is disclosed for use with an imaging apparatus. The imaging apparatus defines a light-tight imaging compartment with an interior wall having a view port extending into the imaging compartment. This view port enables data acquisition of a biological specimen contained in the imaging compartment. The dual illumination system includes a first illumination assembly configured to direct structured light onto a first side of the specimen to enable structured light and surface topography measurements thereof. A second illumination assembly then directs light at the specimen wherein diffused fluorescent light emanates from a surface thereof for receipt through the view port to acquire fluorescence data of the specimen. The combination of structured light imaging and fluorescence imaging enables 3D diffuse tomographic reconstructions of fluorescent probe location and concentration.Type: GrantFiled: May 15, 2006Date of Patent: January 6, 2009Assignee: Xenogen CorporationInventors: David Nilson, Brad Rice, Tamara Troy
-
Patent number: 7466418Abstract: A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained therein. The illumination assembly includes a specimen support surface facing toward the view port of the imaging apparatus. The support surface defines a window portion that enables the passage of light there through. The window portion is selectively sized and dimensioned such that the specimen, when supported atop the support surface, can be positioned and seated over the window portion in a manner forming a light-tight seal substantially there between.Type: GrantFiled: February 1, 2007Date of Patent: December 16, 2008Assignee: Xenogen CorporationInventors: David Nilson, Brad Rice, Tamara Troy
-
Publication number: 20080079802Abstract: The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.Type: ApplicationFiled: October 11, 2007Publication date: April 3, 2008Applicant: XENOGEN CORPORATIONInventors: David Nilson, Michael Cable, Bradley Rice, Kevin Kearney
-
Patent number: 7298415Abstract: The present invention integrates a structured light source into an imaging system for reconstructing surface topography of an object being imaged. The structured light source includes a mechanism for transmitting a set of lines onto the object from an angle. The lines are displaced, or phase shifted relative to a stage, when they encounter an object with finite height, such as a mouse. This phase shift provides structured light information for the object. A camera captures the structured light information. Using software that employs a structured light analysis, surface topography data for the object is determined from the phase shift of the lines.Type: GrantFiled: May 11, 2005Date of Patent: November 20, 2007Assignee: Xenogen CorporationInventors: David Nilson, Michael D. Cable, Bradley W. Rice, Kevin Kearney
-
Publication number: 20070200058Abstract: Described herein is a phantom device that simplifies usage, testing, and development of light imaging systems. The phantom device includes a body and a fluorescent light source internal to the body. The body comprises an optical material designed to at least partially resemble the optical behavior of mammalian tissue. The phantom device has many uses. One use of the phantom device permits testing of tomography software in the imaging system, such as software configured for 3D reconstruction of the fluorescent light source. Another use tests spectral unmixing software in the imaging system. The phantom device also allows a user to compare trans- and epi-fluorescent illumination imaging results.Type: ApplicationFiled: March 6, 2007Publication date: August 30, 2007Applicant: CALIPER LIFE SCIENCES, INC.Inventors: Bradley Rice, David Nilson, Tamara Troy
-
Publication number: 20070127118Abstract: A macroscopic fluorescence illumination assembly is provided for use with an imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained therein. The illumination assembly includes a specimen support surface facing toward the view port of the imaging apparatus. The support surface defines a window portion that enables the passage of light there through. The window portion is selectively sized and dimensioned such that the specimen, when supported atop the support surface, can be positioned and seated over the window portion in a manner forming a light-tight seal substantially there between.Type: ApplicationFiled: February 1, 2007Publication date: June 7, 2007Inventors: David Nilson, Brad Rice, Tamara Troy
-
Patent number: 7190991Abstract: The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.Type: GrantFiled: June 29, 2004Date of Patent: March 13, 2007Assignee: Xenogen CorporationInventors: Michael D. Cable, Bradley W. Rice, David Nilson
-
Patent number: 7177024Abstract: A macroscopic fluorescence illumination assembly is provided for use with an a imaging apparatus with a light-tight imaging compartment. The imaging apparatus includes an interior wall defining a view port extending into the imaging compartment to enable viewing of a specimen contained therein. The illumination assembly includes a specimen support surface sized and dimensioned for receipt in the imaging compartment, and oriented to face toward the view port of the imaging apparatus. The support surface is substantially opaque and defines a window portion that enables the passage of light there through. The window portion is selectively sized and dimensioned such that the specimen, when supported atop the support surface, can be positioned and seated over the window portion in a manner forming a light-tight seal substantially there between.Type: GrantFiled: June 17, 2005Date of Patent: February 13, 2007Assignee: Xenogen CorporationInventors: David Nilson, Brad Rice, Tamara Troy
-
Publication number: 20060258941Abstract: The invention described herein provides systems and methods for multi-modal imaging with light and a second form of imaging. Light imaging involves the capture of low intensity light from a light-emitting object. A camera obtains a two-dimensional spatial distribution of the light emitted from the surface of the subject. Software operated by a computer in communication with the camera may then convert two-dimensional spatial distribution data from one or more images into a three-dimensional spatial representation. The second imaging mode may include any imaging technique that compliments light imaging. Examples include magnetic resonance imaging (MRI) and computer topography (CT). An object handling system moves the object to be imaged between the light imaging system and the second imaging system, and is configured to interface with each system.Type: ApplicationFiled: July 12, 2006Publication date: November 16, 2006Inventors: Michael Cable, Bradley Rice, David Nilson