Abstract: The present disclosure provides a method of predicting a structure of an interface between a target peptide and a targeting peptide. The method leverages test pairs of variants of a target peptide and variants of a targeting peptide and their binding affinities measured by a high-throughput analysis. Synergistic pairs among the test pairs are selected and multiple sequence alignment (MSA) of the selected pairs is performed to predict a structure of the protein complex formed with the target peptide and the targeting peptide. Structure prediction using MSA of the synergistic pairs provides for improved results, thereby paving the path for downstream analyses, e.g., small molecule design for molecular glues or antibody design.

Abstract: A configurable quadrifilar helix antenna is disclosed having a first helical antenna, a second helical antenna, a third helical antenna, and a fourth helical antenna each disposed on a cylindrical dielectric. On a bottom portion of the cylindrical dielectric is coupled a configurable circuit. The configurable circuit includes a first hybrid coupler and a second hybrid coupler, whereby based on linkage settings to the first and second hybrid coupler, the quadrifilar helix antenna is configured to have a first phasing sequence generating a first radiation pattern. Alternatively, the quadrifilar helix antenna may have a second phasing sequence generating a second radiation pattern.

Abstract: A safety razor adapted to deliver a non-solid shaving aid material during normal use includes a handle, a razor cartridge and a reservoir for the shaving aid material in fluid communication with an applicator of the razor cartridge. A linkage extends from the reservoir to the razor cartridge. Pivotal movement of the razor cartridge away from its at-rest position causes the linkage to move relative to both the razor cartridge and the reservoir and in particular away from the reservoir. A plug of the linkage is removed from a vent aperture of the reservoir providing pressure relief for any partial vacuum caused from dispensing a portion of the shaving aid material. In the at-rest position the plug seals the vent and helps alleviate unwanted drooling of the shaving aid material when the safety razor is not in use.

Abstract: An inhabitable space frame (100) can define and support inhabitable living space within, around and projecting from the exterior of the perimeter of the space frame (100). The space frame (100) includes a vector matrix of strut members (105) that defines a plurality of interconnected basic tetrahedral modules (110) and, optionally, a plurality of prime octahedral modules (115). At least a part of each prime octahedral module (115) in the plurality of prime octahedral modules (115) is adjacent to at least two of the basic tetrahedral modules (110). Use of one or more right triangular faces, or planes, within a repeating geometry of a vector matrix enables an interior of the space frame (100) to be inhabitable, with horizontal floors and vertical walls aligned with associated strut members (105).

Abstract: An inhabitable space frame (100) can define and support inhabitable living space within, around and projecting from the exterior of the perimeter of the space frame (100). The space frame (100) includes a vector matrix of strut members (105) that defines a plurality of interconnected basic tetrahedral modules (110) and, optionally, a plurality of prime octahedral modules (115). At least a part of each prime octahedral module (115) in the plurality of prime octahedral modules (115) is adjacent to at least two of the basic tetrahedral modules (110). Use of one or more right triangular faces, or planes, within a repeating geometry of a vector matrix enables an interior of the space frame (100) to be inhabitable, with horizontal floors and vertical walls aligned with associated strut members (105).

Abstract: A shaving system includes a safety razor and a base station spaced apart from one another. The base station has a reservoir adapted to contain a shaving aid material capable of fluid flow. The base station is linked to the safety razor by an umbilical to provide fluid communication between the reservoir and an applicator of the safety razor to deliver the shaving aid material to the skin surface of a user during a shaving operation. A pump can be provided to propel the shaving aid material. A sensor can be provided to initiate operation of the pump. The reservoir can be refillable or replaceable.

Abstract: A design tool includes a service definition model to enable abstract description of distributed computing systems and distributed applications. The design tool also includes a schema to dictate how functional operations within the service definition model are to be specified. The functional operations include design of distributed applications, deployment of distributed applications, and management of distributed applications.

Abstract: The present invention is related to a shaving implement that includes at least a razor cartridge and a mechanism. The razor cartridge includes at least one blade that has a sharpened cutting edge and defines a blade plane. The mechanism is disposed in the shaving plane and moves the blade in the blade plane during shaving. The mechanism may be either a vibration mechanism (i.e., a motorized spinning eccentric weight), or a dithering mechanism (i.e., a piezoelectric element). The cut force required to shave, when the blades are moving in the blade plane, is significantly reduced.

Abstract: A shaving system includes a safety razor and a base station spaced apart from one another. The base station has a reservoir adapted to contain a shaving aid material capable of fluid flow. The base station is linked to the safety razor by an umbilical to provide fluid communication between the reservoir and an applicator of the safety razor to deliver the shaving aid material to the skin surface of a user during a shaving operation. A pump can be provided to propel the shaving aid material. A sensor can be provided to initiate operation of the pump. The reservoir can be refillable or replaceable.

Abstract: A design tool includes a service definition model to enable abstract description of distributed computing systems and distributed applications. The design tool also includes a schema to dictate how functional operations within the service definition model are to be specified. The functional operations include design of distributed applications, deployment of distributed applications, and management of distributed applications.

Abstract: A design tool includes a service definition model to enable abstract description of distributed computing systems and distributed applications. The design tool also includes a schema to dictate how functional operations within the service definition model are to be specified. The functional operations include design of distributed applications, deployment of distributed applications, and management of distributed applications.

Abstract: A design tool includes a service definition model to enable abstract description of distributed computing systems and distributed applications. The design tool also includes a schema to dictate how functional operations within the service definition model are to be specified. The functional operations include design of distributed applications, deployment of distributed applications, and management of distributed applications.

Abstract: The present invention is related to a shaving implement that includes at least a razor cartridge and a mechanism. The razor cartridge includes at least one blade that has a sharpened cutting edge and defines a blade plane. The mechanism is disposed in the shaving plane and moves the blade in the blade plane during shaving. The mechanism may be either a vibration mechanism (i.e., a motorized spinning eccentric weight), or a dithering mechanism (i.e., a piezoelectric element). The cut force required to shave, when the blades are moving in the blade plane, is significantly reduced.

Abstract: A design tool includes a service definition model to enable abstract description of distributed computing systems and distributed applications. The design tool also includes a schema to dictate how functional operations within the service definition model are to be specified. The functional operations include design of distributed applications, deployment of distributed applications, and management of distributed applications.

Abstract: A design tool includes a service definition model to enable abstract description of distributed computing systems and distributed applications. The design tool also includes a schema to dictate how functional operations within the service definition model are to be specified. The functional operations include design of distributed applications, deployment of distributed applications, and management of distributed applications.

Abstract: A design tool includes a service definition model to enable abstract description of distributed computing systems and distributed applications. The design tool also includes a schema to dictate how functional operations within the service definition model are to be specified. The functional operations include design of distributed applications, deployment of distributed applications, and management of distributed applications.

Abstract: Systems and methods for designing systems that include computer applications hosted on hosting environments are disclosed. The hosting environments are modeled to include hosting environment settings and constraints placed on applications. The applications are also modeled to include application settings and constraints placed on the hosting environments. Hosting environment and application models are then used to validate designs by confirming that settings are in compliance with the constraints.