Patents by Inventor David O'Leary
David O'Leary has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11964989Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.Type: GrantFiled: July 20, 2022Date of Patent: April 23, 2024Assignees: Mirati Therapeutics, Inc., Array BioPharma Inc.Inventors: Xiaolun Wang, Aaron Craig Burns, James Gail Christensen, John Michael Ketcham, John David Lawson, Matthew Arnold Marx, Christopher Ronald Smith, Shelley Allen, James F. Blake, Mark Joseph Chicarelli, Joshua Ryan Dahlke, Donghua Dai, Jay Bradford Fell, John Peter Fischer, Macedonio J. Mejia, Brad Newhouse, Phong Nguyen, Jacob Matthew O'Leary, Spencer Pajk, Martha E. Rodriguez, Pavel Savechenkov, Tony P. Tang, Guy P.A. Vigers, Qian Zhao, Dean Russell Kahn, John Gaudino, Michael Christopher Hilton
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Patent number: 10765820Abstract: A dry powder inhalation apparatus includes a housing, a reservoir for medicament located within the housing, a mouthpiece disposed on the housing for insertion in the mouth of a user for inhalation of a predetermined dose of medicament, a delivery channel between a discharge outlet of the reservoir and the mouthpiece for delivering the predetermined dose of medicament, a device positioned within the housing and normally held adjacent the reservoir for receiving the predetermined dose of medicament from the discharge outlet and transferring it to the delivery channel, and a release mechanism adapted to release the device and permit controlled movement thereof to the delivery channel for the delivery, the release mechanism being located at least partially outside of the housing for manual operation by the user.Type: GrantFiled: August 12, 2016Date of Patent: September 8, 2020Assignee: NORTON HEALTHCARE LTD.Inventors: Brian Barney, David O'Leary, Rachel Striebig
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Patent number: 9963752Abstract: Conductive leather materials and methods for making the same are provided. The conductive leather materials may have a conductivity suitable to operate touch-sensitive electronic devices without a conductive path to the human body.Type: GrantFiled: August 2, 2013Date of Patent: May 8, 2018Assignee: Fownes Brothers & Co., Inc.Inventor: David O'Leary
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Publication number: 20170021119Abstract: A dry powder inhalation apparatus includes a housing, a reservoir for medicament located within the housing, a mouthpiece disposed on the housing for insertion in the mouth of a user for inhalation of a predetermined dose of medicament, a delivery channel between a discharge outlet of the reservoir and the mouthpiece for delivering the predetermined dose of medicament, a device positioned within the housing and normally held adjacent the reservoir for receiving the predetermined dose of medicament from the discharge outlet and transferring it to the delivery channel, and a release mechanism adapted to release the device and permit controlled movement thereof to the delivery channel for the delivery, the release mechanism being located at least partially outside of the housing for manual operation by the user.Type: ApplicationFiled: August 12, 2016Publication date: January 26, 2017Inventors: Brian Barney, David O'Leary, Rachel Striebig
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Patent number: 9463288Abstract: A dry powder inhalation apparatus operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device normally held adjacent a reservoir for receiving medicament in a cup or receptacle and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device is achieved by a yoke acting on an abutment thereof. Spillage of medicament in the apparatus is avoided.Type: GrantFiled: January 24, 2014Date of Patent: October 11, 2016Assignee: NORTON HEALTHCARE LTD.Inventors: Brian Barney, David O'Leary, Rachel Striebig
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Publication number: 20140137863Abstract: A dry powder inhalation apparatus operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device normally held adjacent a reservoir for receiving medicament in a cup or receptacle and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device is achieved by a yoke acting on an abutment thereof. Spillage of medicament in the apparatus is avoided.Type: ApplicationFiled: January 24, 2014Publication date: May 22, 2014Applicant: NORTON HEALTHCARE LTD.Inventors: Brian Barney, David O'Leary, Rachel Striebig
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Publication number: 20140099431Abstract: Conductive leather materials and methods for making the same are provided. The conductive leather materials may have a conductivity suitable to operate touch-sensitive electronic devices without a conductive path to the human body.Type: ApplicationFiled: August 2, 2013Publication date: April 10, 2014Applicant: Fownes Brothers & Co., Inc.Inventor: David O'Leary
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Patent number: 8651103Abstract: The invention relates to dry powder inhalation apparatus usually operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device (4) normally held adjacent a reservoir for receiving medicament in a cup or receptacle (15) and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device (4) is achieved by a yoke acting on an abutment (16) thereof. Spillage of medicament in the apparatus is avoided.Type: GrantFiled: October 2, 2004Date of Patent: February 18, 2014Assignee: Norton Healthcare Ltd.Inventors: Brian Barney, David O'Leary, Rachel Striebig
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Patent number: 8507102Abstract: Conductive leather materials and methods for making the same are provided. The conductive leather materials may have a conductivity suitable to operate touch-sensitive electronic devices without a conductive path to the human body.Type: GrantFiled: August 7, 2012Date of Patent: August 13, 2013Assignee: Fownes Brothers & Co., Inc.Inventor: David O'Leary
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Publication number: 20120024386Abstract: An apparatus is provided for draining and cleaning a tank under pressure. The apparatus comprises a conduit and a supply pipe. The conduit has a first end and a second end, the first end of the conduit for connecting to a drain port of the tank. The conduit drains water from the tank. The supply pipe resides within the conduit for delivering a pressurized fluid to the tank. The supply pipe has a first end and a second end. The first end of the supply pipe corresponds with the first end of the conduit. The pressurized fluid is introduced into the tank through the supply pipe to pressurize the tank for rapidly draining the water from the tank through the conduit.Type: ApplicationFiled: July 29, 2010Publication date: February 2, 2012Inventor: David O'LEARY
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Patent number: 8006690Abstract: An inhaler includes an accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses, and a dose counting system indicating the number of doses dispensed by or remaining in the inhaler.Type: GrantFiled: March 23, 2009Date of Patent: August 30, 2011Assignee: Norton Healthcare LtdInventor: David O'Leary
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Publication number: 20090205657Abstract: A dry powder inhaler including a housing having a mouthpiece and a delivery passageway connected to the mouthpiece, a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, and wherein the magazine is movable within the housing so that the reservoirs are sequentially positioned within the delivery passageway of the housing upon movement of the magazine, a cover connected to the housing and movable to open and close the mouthpiece of the housing, and a rake connected to the cover, extending into the housing and engageable with the magazine so that, upon the cover being moved to open the mouthpiece, the rake moves the magazine and causes one of the reservoirs of the magazine to be positioned within the delivery passageway.Type: ApplicationFiled: January 16, 2009Publication date: August 20, 2009Applicant: Norton Healthcare LtdInventors: Brian Barney, David O'Leary, Esther Perea-Borobio, Andrew Dickson, Sophia Chew, Rachel Striebig
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Publication number: 20090178678Abstract: An inhaler includes an accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses, and a dose counting system indicating the number of doses dispensed by or remaining in the inhaler.Type: ApplicationFiled: March 23, 2009Publication date: July 16, 2009Applicant: NORTON HEALTHCARE LTDInventor: David O'Leary
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Patent number: 7540282Abstract: An inhaler includes an accurate and consistent mechanical dose metering system that dispenses dry powdered medicament in discrete amounts or doses for patient inhalation, a pressure relief system that manages pressure within a medicament reservoir of the inhaler to ensure consistently dispensed doses, and a dose counting system indicating the number of doses remaining in the inhaler.Type: GrantFiled: June 23, 2001Date of Patent: June 2, 2009Assignee: Norton Healthcare LtdInventor: David O'Leary
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Patent number: 7503324Abstract: A dry powder inhaler including a housing having a mouthpiece and a delivery passageway connected to the mouthpiece, a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, and wherein the magazine is movable within the housing so that the reservoirs are sequentially positioned within the delivery passageway of the housing upon movement of the magazine, a cover connected to the housing and movable to open and close the mouthpiece of the housing, and a rake connected to the cover, extending into the housing and engageable with the magazine so that, upon the cover being moved to open the mouthpiece, the rake moves the magazine and causes one of the reservoirs of the magazine to be positioned within the delivery passageway.Type: GrantFiled: February 20, 2004Date of Patent: March 17, 2009Assignee: Norton Healthcare LtdInventors: Brian Barney, David O'Leary, Esther Perea-Borobio, Andrew Dickson, Sophia Chew, Rachel Striebig
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Publication number: 20080314383Abstract: The invention relates to dry powder inhalation apparatus usually operable by breath of a user which provides for controlled and smooth transfer of medicament during multiple actuations by a user. A mechanism of the apparatus for achieving this controlled and smooth transfer includes a device (4) normally held adjacent a reservoir for receiving medicament in a cup or receptacle (15) and which is generally movable transversely of a longitudinal axis of the apparatus to delivery channels of the apparatus. This bodily shifting of the device (4) is achieved by a yoke acting on an abutment (16) thereof. Spillage of medicament in the apparatus is avoided.Type: ApplicationFiled: October 2, 2004Publication date: December 25, 2008Applicant: Norton Healthcare Ltd.Inventors: Brian Barney, David O'Leary, Rachel Striebig
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Patent number: 7261102Abstract: A medicament delivery system comprises a nebulizer device, an open-faced mist chamber-defining element having a tubular input/output port, a tubular inhalation port connecting to the output port of the mist chamber-defining element, and a sealed unit dose ampoule adapted to fit within the mist chamber-defining element. The nebulizer device includes an ultrasonic transducer responsive to applied electrical energy to generate ultrasonic energy, an ultrasonic transmission horn between an input energy surface at an input end and an energy delivery surface at an output end. The sealed unit dose ampoule can be placed directly into the nebulizer device and acts as both the dose cup and baffle, so that the chance of spillage of drug and the number of components to be cleaned are minimized.Type: GrantFiled: August 30, 2002Date of Patent: August 28, 2007Assignee: Norton Healthcare Ltd.Inventors: Brian Barney, Sophia Chew, Paul Fairburn, David O'Leary, Rachel Striebig
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Publication number: 20060157053Abstract: A dry powder inhaler including a housing having a mouthpiece and a delivery passageway connected to the mouthpiece, a magazine positioned within the housing and including a plurality of reservoirs for holding doses of dry powder, and wherein the magazine is movable within the housing so that the reservoirs are sequentially positioned within the delivery passageway of the housing upon movement of the magazine, a cover connected to the housing and movable to open and close the mouthpiece of the housing, and a rake connected to the cover, extending into the housing and engageable with the magazine so that, upon the cover being moved to open the mouthpiece, the rake moves the magazine and causes one of the reservoirs of the magazine to be positioned within the delivery passageway.Type: ApplicationFiled: February 20, 2004Publication date: July 20, 2006Inventors: Brian Barney, David O'Leary, Esther Perea-Borobio, Andrew Dickson, Sophia Chew, Rachel Striebig
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Publication number: 20050081845Abstract: A medicament delivery system comprises a nebulizer device, an open-faced mist chamber-defining element having a tubular input/output port, a tubular inhalation port connecting to the output port of the mist chamber-defining element, and a sealed unit dose ampoule adapted to fit within the mist chamber-defining element. The nebulizer device includes an ultrasonic transducer responsive to applied electrical energy to generate ultrasonic energy, an ultrasonic transmission horn between an input energy surface at an input end and an energy delivery surface at an output end. The sealed unit dose ampoule can be placed directly into the nebulizer device and acts as both the dose cup and baffle, so that the chance of spillage of drug and the number of components to be cleaned are minimized. The unit dose ampoule has a conical base to allow ultrasonic energy conducted from the ultrasonic system to be concentrated at the base of the ampoule. The inhalation port includes an inhalation valve and an exhalation valve.Type: ApplicationFiled: August 30, 2002Publication date: April 21, 2005Inventors: Brian Barney, Sophia Chew, Paul Fairburn, David O'Leary, Rachel Striebig
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Patent number: 6871646Abstract: A de-agglomerator is provided for use with a breath-actuated dry powder inhaler for breaking up aggregates and micronizing particles of dry powder prior to inhalation of the powder by a patient using the inhaler. The de-agglomerator includes an inner wall defining a swirl chamber extending along an axis from a first end to a second end, a dry powder supply port, an inlet port, and an outlet port. The supply port is in the first end of the swirl chamber for providing fluid communication between a dry powder delivery passageway of an inhaler and the first end of the swirl chamber. The inlet port is in the inner wall of the swirl chamber adjacent to the first end of the swirl chamber and provides fluid communication between a region exterior to the de-agglomerator and the swirl chamber.Type: GrantFiled: April 30, 2004Date of Patent: March 29, 2005Assignee: Norton Healthcare Ltd.Inventors: Laurence Keane, David O'Leary