Abstract: A process for the production of a three-dimensional particulate structure embedded in a body formed of a hydrogel matrix, comprising the steps of forming a layer of a hydrogel matrix having a particulate substructure embedded therein by subjecting a suspension of particulates in a layer of a hydrogel matrix precursor to standing acoustic waves (SAWs) to spatially partition the particulates within the layer of hydrogel precursor into a particulate substructure and allowing the hydrogel precursor to solidify such as to form the layer of a hydrogel matrix having a particulate substructure embedded therein, and repeating the process until the three-dimensional particulate structure embedded in a body formed of a hydrogel matrix is formed.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: A toe protection assembly for inhibiting toes in a foot cast from being stubbed includes a basal strap that is positionable beneath a foot cast. A top strap is pivotally coupled to the basal strap such that the top strap can be extended over the foot cast when the basal strap is positioned beneath the foot cast. A ratchet strap is pivotally coupled to the basal strap such that the ratchet strap can be extended over the foot cast when the basal strap is positioned beneath the foot cast. A ratchet is coupled to the ratchet strap and the ratchet tightens the top strap across the foot cast. A barrier is coupled to the basal strap and the barrier extends across toes on a foot that is positioned in the foot cast. Moreover, the barrier is comprised of a rigid material to inhibit the toes from being stubbed during walking with the foot cast.

Abstract: A process for the production of a three-dimensional particulate structure embedded in a body formed of a hydrogel matrix, comprising the steps of forming a layer of a hydrogel matrix having a particulate substructure embedded therein by subjecting a suspension of particulates in a layer of a hydrogel matrix precursor to standing acoustic waves (SAWs) to spatially partition the particulates within the layer of hydrogel precursor into a particulate substructure and allowing the hydrogel precursor to solidify such as to form the layer of a hydrogel matrix having a particulate substructure embedded therein, and repeating the process until the three-dimensional particulate structure embedded in a body formed of a hydrogel matrix is formed.

Abstract: A toe protection assembly for inhibiting toes in a foot cast from being stubbed includes a basal strap that is positionable beneath a foot cast. A top strap is pivotally coupled to the basal strap such that the top strap can be extended over the foot cast when the basal strap is positioned beneath the foot cast. A ratchet strap is pivotally coupled to the basal strap such that the ratchet strap can be extended over the foot cast when the basal strap is positioned beneath the foot cast. A ratchet is coupled to the ratchet strap and the ratchet tightens the top strap across the foot cast. A barrier is coupled to the basal strap and the barrier extends across toes on a foot that is positioned in the foot cast. Moreover, the barrier is comprised of a rigid material to inhibit the toes from being stubbed during walking with the foot cast.

Abstract: Immediate release, oral, pharmaceutical formulation comprising nalbuphine or a pharmaceutically acceptable salt thereof, and at least one hydrophilic granulation carrier, one hydrophilic binder and one lubricant.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Immediate release, oral, pharmaceutical formulation comprising nalbuphine or a pharmaceutically acceptable salt thereof, and at least one hydrophilic granulation carrier, one hydrophilic binder and one lubricant.

Abstract: The present invention provides for a method for preparing a thermosensitive hyaluronic acid conjugate comprising the steps of contacting, in any order, a. a predefined amount of hyaluronic acid, b. a predefined amount of one or more thermosensitive polymers having at least one terminal amine moiety and c. a predefined amount of a 1,3,5-triazine (or s-triazine) compound; as well as the conjugates obtainable thereby.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: A biocompatible implant for bone repair comprising a flexible membrane fitted around a bone defect and a platelet-rich plasma gel composition contained within the void space created by the membrane, its application and kit of parts thereof are described.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: Method enabling a user to verify the operation of a personal cryptographic device, comprising the following steps: a) a user (2) enters an access request in a terminal (3) (100), d) a personal cryptographic device (1) of the user (2) calculates and displays a response (105), g) the user (2) verifies the operation of the personal cryptographic device (1) by requesting the terminal (3) to display the expected response to the challenge (110), i) the terminal (3) displays the expected response to the challenge (113), j) the user (2) compares the response displayed by the personal cryptographic device with the response displayed by the terminal.

Abstract: The invention provides for systems, methods, and compositions for manipulation of sequences and/or activities of target sequences. Provided are vectors and vector systems, some of which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for selecting specific cells by introducing precise mutations utilizing the CRISPR/Cas system.

Abstract: A method for updating data to ensure the correct version of the data is available for a user of a second data system. In the second data system, an update request is received from a first data entity to update the data in a component of the second data system. The update request comprises an updated version of the data. The updated version of the data is compared with a currently stored version of the data in the second component to determine a change therein. An operating function representative of the change in the data is produced. The operating function is applied to the currently stored version of the standard data to produce resulting data. The operating function is stored to ensure the correct version of the data is capable of being output if requested.

Abstract: The present invention relates to pharmaceutical compositions comprising a 2-amino-2-[2-(4-C2-20-alkyl-phenypethyl]propane-1,3-diol compound or a pharmaceutically acceptable salt thereof, and to the use thereof for treating, preventing or delaying the progression of multiple sclerosis in a paediatric patient or a patient suffering from a specific condition.

Abstract: A method for updating data to ensure the correct version of the data is available for a user of a second data system. In the second data system, an update request is received from a first data entity to update the data in a component of the second data system. The update request comprises an updated version of the data. The updated version of the data is compared with a currently stored version of the data in the second component to determine a change therein. An operating function representative of the change in the data is produced. The operating function is applied to the currently stored version of the standard data to produce resulting data. The operating function is stored to ensure the correct version of the data is capable of being output if requested.