Abstract: A Windkessel simulation apparatus includes a flexible fluid container that cyclically fills with a perfusate fluid, such as blood, and helps deliver the perfusate fluid to a set of organs, by means of an elastic reactive squeezing mechanism that applies compressive force proportional to the pressure in the flexible fluid container. The apparatus acts as a hydraulic capacitor, similarly to how arteries act in the body—inflating during systole, and squeezing during diastole. In this way, the apparatus may help simulate a natural circulatory system for a set of organs.

Abstract: A Windkessel simulation apparatus includes a flexible fluid container that cyclically fills with a perfusate fluid, such as blood, and helps deliver the perfusate fluid to a heart, by means of an elastic reactive squeezing mechanism that applies compressive force proportional to the pressure in the flexible fluid container. The apparatus acts as a hydraulic capacitor, similarly to how arteries act in the body-inflating during systole, and squeezing during diastole. In this way, the apparatus may help simulate a natural circulatory system for an organ, such as an ex vivo heart.

Abstract: A pulsatile fluid pump system includes a pump-valving assembly including a chamber and a diaphragm assembly coupled to the chamber and including a flexible diaphragm. The diaphragm assembly and the pump-valving assembly are configured as an integral pump assembly. The system further includes a linear motor having a magnet and a coil, the magnet moving in relation to the coil, the coil having an electrical input. The system also includes a control housing rigidly coupled to the linear motor and a controller system having an electrical output coupled to the electrical input of the coil, the controller system defining an electrical waveform at the electrical output to cause desired operation of the diaphragm. The integral pump assembly is configured to be removably coupled to the control housing, and the diaphragm assembly of the integral pump assembly is configured to be removably coupled to the linear motor.

Abstract: A pulsatile fluid pump system includes a pump-valving assembly including a chamber and a diaphragm assembly coupled to the chamber and including a flexible diaphragm. The diaphragm assembly and the pump-valving assembly are configured as an integral pump assembly. The system further includes a linear motor having a magnet and a coil, the magnet moving in relation to the coil, the coil having an electrical input. The system also includes a control housing rigidly coupled to the linear motor and a controller system having an electrical output coupled to the electrical input of the coil, the controller system defining an electrical waveform at the electrical output to cause desired operation of the diaphragm. The integral pump assembly is configured to be removably coupled to the control housing, and the diaphragm assembly of the integral pump assembly is configured to be removably coupled to the linear motor.

Abstract: A pulsatile fluid pump apparatus includes an integral pump assembly employing a flexible diaphragm in a diaphragm assembly; a pulsatile fluid pump system including a control housing, for removably receiving the integral pump assembly, the control housing and the integral pump assembly being configured for operation, in a first mode, so that the pulsatile fluid pump system reciprocally actuates the diaphragm assembly to cause pumping automatically; and a manual driver assembly, wherein the integral pump assembly is configured, in a second mode, in the absence of actuation of the diaphragm assembly by the pulsatile fluid pump system, to removably receive the manual driver assembly to support manual actuation and operation of the diaphragm assembly.

Abstract: A pulsatile fluid pump system includes a pump-valving assembly including a chamber and a diaphragm assembly coupled to the chamber and including a flexible diaphragm. The diaphragm assembly and the pump-valving assembly are configured as an integral pump assembly. The system further includes a linear motor having a magnet and a coil, the magnet moving in relation to the coil, the coil having an electrical input. The system also includes a control housing rigidly coupled to the linear motor and a controller system having an electrical output coupled to the electrical input of the coil, the controller system defining an electrical waveform at the electrical output to cause desired operation of the diaphragm. The integral pump assembly is configured to be removably coupled to the control housing, and the diaphragm assembly of the integral pump assembly is configured to be removably coupled to the linear motor.

Abstract: A pulsatile fluid pump system for driving a fluid pump assembly includes a reciprocating linear motor having a magnet and a coil, the magnet moving in relation to the coil, the coil having an electrical input. The pulsatile fluid pump system further includes a controller system having an electrical output coupled to the electrical input of the coil, and the controller system is configured to execute a waveform program defining an electrical waveform at the electrical output. The waveform program is configured to control operation of the linear motor by modification of a feature, selected from the group consisting of amplitude, frequency, shape, and combinations thereof, of the electrical waveform at the electrical output. The waveform program is further configured to accept a set of user-specifiable parameters defining the performance of the linear motor and to modify the electrical waveform in response to such parameters.