Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for automatic digital image rotation are disclosed. A method includes obtaining an image of a head of a firearm cartridge casing; identifying, in the image of the head of the firearm cartridge casing, one or more markings on the head of the firearm cartridge casing; determining, using the identified one or more markings, an orientation of the firearm cartridge casing in the image; determining a target orientation of the firearm cartridge casing; and rotating the image of the firearm cartridge casing to align the orientation of the firearm cartridge casing in the image with the target orientation. The one or more markings include at least one of scratch marks, shear marks, and drag marks. The one or more markings include a breechface pattern.

Abstract: The present invention relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. The present invention also relates to compositions which comprise at least one dihydroisoxazole compound of the invention. The invention also provides methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of a dihydroisoxazole of the invention and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

Abstract: Provided herein are affinity matured anti-galectin-9 (Gal9) antibodies. The antibodies have improved binding affinity to Gal9. Also provided herein are method of use of the affinity matured anti-Gal9 antibodies, including methods of treatment of cancer, methods of rescuing or promoting effector T cell proliferation, methods of enhancing effector T cell activity, and/or of identifying and treating cancer in a subject including the administration of the anti-Gal9 antibodies described herein. Also provided are polynucleotides encoding the heavy chain or the light chain or the antigen-binding portion thereof described herein, and vectors, especially expression vectors, including the polynucleotides described herein.

Abstract: Disclosed are dihydroisoxazole compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, E, and R1 are as defined herein. Also disclosed are compositions which comprise at least one of these dihydroisoxazole compounds, methods for inhibiting growth of mycobacterial cells as well as a method of treating mycobacterial infections by Mycobacterium tuberculosis comprising administering a therapeutically effective amount of these dihydroisoxazole compounds and/or a pharmaceutically acceptable salt thereof, or a composition comprising such compound and/or salt.

Abstract: A method for providing a decentralized blockchain database comprising energy information for homes includes receiving an application for energy certification of a home, wherein the application includes information on an owner of the home and at least one energy device installed at the home, generating a smart contract associated with the home, wherein the smart contract is configured to track data on energy usage by the at least one energy device installed at the home, and generating an NFT based on the smart contract associated with the home to be maintained on the decentralized blockchain database, wherein metadata of the NFT comprises information on energy efficiency of the home including the at least one energy device.

Abstract: A print liquid supply apparatus comprising a container to hold print liquid and an interface structure to fluidically connect the container to a receiving station wherein the interface structure projects outwards with respect to the container and comprises a liquid interface to fluidically connect to a corresponding fluidic interface of the receiving station and a liquid channel fluidically connecting the container and the liquid interface.

Abstract: A print liquid supply apparatus or interface structure to be connected to a print system comprises a liquid channel, liquid interface and integrated circuit contact pads.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for a forensic imaging apparatus for documentation, forensic analysis, and reporting of bullet casings. In one aspect, an assembly includes an adaptor for attaching the assembly to a user device, a housing defining a barrel extending along an axis and attached to the adaptor and having an opening that is sufficiently large to receive a firearm cartridge casing, and a holder for holding the firearm cartridge casing at an illumination plane within the barrel. Light sources are arranged within the housing and to direct light to illuminate the illumination plane, the light sources including a first light source arranged to illuminate the illumination plane at a first range of glancing incident angles.

Abstract: An interface structure connectable to a separate liquid reservoir, to connect that liquid reservoir to a receiving station, comprising a liquid interface to fluidically connect to at least one liquid needle of the receiving station, a liquid channel, to fluidically connect the liquid interface to the reservoir, a support wall supporting an integrated circuit laterally next to the liquid channel, the integrated circuit having contact pad contact surfaces, and a front push area adjacent the liquid, the front push area terminating at a front edge that defines a profile height of the interface structure, between said front edge and an opposite distal edge.

Abstract: A microfluidic device is described. The device comprises a flow channel; and at least one reaction chamber. The at least one reaction chamber comprises a chamber inlet connecting the at least one reaction chamber to the flow channel, a first region adjacent the chamber inlet, a second region spaced from the chamber inlet by the first region, a vent channel and a reaction reagent disposed on at least one inner surface of the second region. Also described is a PCR apparatus and a method of performing PCR.

Abstract: An interface structure connectable to a separate liquid reservoir, to connect that liquid reservoir to a receiving station, comprising a liquid interface to fluidically connect to at least one liquid needle of the receiving station, a liquid channel, to fluidically connect the liquid interface to the reservoir, a support wall supporting an integrated circuit laterally next to the liquid channel, the integrated circuit having contact pad contact surfaces, and a front push area adjacent the liquid, the front push area terminating at a front edge that defines a profile height of the interface structure, between said front edge and an opposite distal edge.

Abstract: A metered volume microfluidic device can include fluid flow microfluidics. The fluid flow microfluidics can include an inflow channel, a metered volume chamber positioned to receive working fluid from the inflow channel, a metered volume outflow channel positioned to receive and direct a metered volume of the working fluid when discharged from the metered volume chamber, and a capillary check valve. The capillary check valve can allow excess working fluid to exit the metered volume chamber when filling the metered volume chamber via the inflow channel. The capillary check valve can also prevent excess working fluid that has passed there through from being reintroduced into the metered volume chamber when the working fluid is discharged into the metered volume outflow channel.

Abstract: A print liquid supply interface structure is provided, to fluidically connect a fluid supply container to a receiving station, comprising a liquid channel having at least one liquid channel wall, the liquid channel including a liquid interface, and at least one key pen next and parallel to the needle receiving portion of the liquid channel. In another example a key pen structure is provided. In yet another example an interface structure for receiving a separate key pen is provided.

Abstract: A printable liquid supply cartridge includes a printable liquid reservoir extending between a first side and a second side, and between a front end and a rear end. The front end includes a printable liquid outlet to receive a first fluid pen and a gas inlet, above the printable liquid outlet, to receive a second fluid pen. The front end also includes an interface support at the first side, the support having an I2C data interface that includes electrical connection pads exposed on an interior side of the support to face from the first side towards the second side, the electrical connection pads being arranged vertically and to make contact with the printer data interface at least partially inserted into the second portion.