Patents by Inventor David Onyabe

David Onyabe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial packaging strains useful for generation and production of recombinant double-stranded RNA nucleocapsids and uses thereof
    Patent number: 8053568
    Abstract: Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo.
    Type: Grant
    Filed: November 23, 2005
    Date of Patent: November 8, 2011
    Assignee: Aeras Global TB Vaccine Foundation
    Inventors: David Hone, John Fulkerson, Jerald C. Sadoff, David Onyabe, Michele Stone
  • Replication-proficient dsRNA capsids and uses thereof
    Publication number: 20100322951
    Abstract: Compositions and methods useful in the production of proteins in vitro and in vivo are provided. In particular, this invention provides bionanoparticles comprised of replication-proficient, double-stranded RNA (dsRNA) capsids which are capable of transfecting, for example, target bacterial, yeast, plant and mammalian cells, and causing expression of genes of interest in said transfected cells. The bionanoparticles comprised of replication-proficient, dsRNA capsids are also capable of expressing genes of interest in vitro. The genes of interest can encode proteins that are useful, for example, as research reagents, therapeutics and vaccines. Also described are methods that enable the construction of bionanoparticles comprised of replication-proficient dsRNA capsids and methods for transfecting cells with said bionanoparticles and expressing said genes of interest in transfected cells and in vitro.
    Type: Application
    Filed: December 31, 2007
    Publication date: December 23, 2010
    Applicant: BACILLIGEN, INC.
    Inventors: David Hone, David Onyabe
  • Bacterial Packaging Strains Useful for Generation and Production of Recombinant Double-Stranded RNA Nucleocapsids and Uses Thereof
    Publication number: 20080107683
    Abstract: Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo.
    Type: Application
    Filed: May 30, 2007
    Publication date: May 8, 2008
    Inventors: David Hone, John Fulkerson, Jerald C. Sadoff, David Onyabe, Michele Stone
  • Webbed HIV envelope immunogens, methods for production and use of same
    Publication number: 20070014814
    Abstract: HIV envelope immunogens that display multivalent epitopes are provided. The immunogens are aggregated, “webbed” HIV envelope immunogens in which native envelope structures are stabilized due to interactions with multimeric derivatives of M9 scorpion toxin.
    Type: Application
    Filed: June 2, 2006
    Publication date: January 18, 2007
    Inventors: David Hone, David Onyabe
  • Bacterial packaging strains useful for generation and production of recombinant double-stranded RNA nucleocapsids and uses thereof
    Publication number: 20060115493
    Abstract: Bacterial packaging strains useful for generating recombinant double-stranded RNA nucleocapsids (rdsRNs) are provided. The packaging strains are useful for the production of RNA encoding vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo.
    Type: Application
    Filed: November 23, 2005
    Publication date: June 1, 2006
    Inventors: David Hone, John Fulkerson, Jerald Sadoff, David Onyabe, Michele Stone