Abstract: The present disclosure provides antibodies and antigen-binding fragments capable of binding PAR2. In some embodiments, the anti-PAR2 antibodies or antigen-binding fragments thereof bind PAR2 in a pH-dependent manner. The disclosure further provides methods for making and using the antibodies and antigen-binding fragments.

Abstract: Holographic and spotlight metamaterial apertures for microwave and millimeter wave imaging and methods of use are disclosed. According to an aspect, an imaging system includes metamaterial elements being spaced apart and configured to respond to an electromagnetic field for radiating in a predetermined pattern to illuminate a scene. The imaging system also includes one or more antennas configured to generate a signal for imaging based on the illuminated scene.

Abstract: The present invention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from quinolones, NSAIDs and mixtures thereof. The present invention also relates to methods for preparing the polymer conjugates using click cycloaddition chemical reactions, to monomer-bioactive agent conjugates suitable for preparing the polymer conjugates, and to pharmaceutical products comprising the polymer conjugates for the post-surgical care to treat or prevent infections, provide analgesia and treat inflammation.

Abstract: A readily removable expanding precision holding and locating pin for securing parts to a work surface or assembly. This device works equally well as a threaded in insert with controlled fit counter bore, press fit or controlled fit bore, a taper fit etc. allowing the device to be used in many standard fixtures without modification the fixture, for example, tombstone fixtures mounted on horizontal machining centers. The device itself can be furnished as an oversize mandrel that can be machined to less than 50% of its original diameter. The device holds and can position in the X, Y, Z, directions and also resists rotation along the C/L Axis.

Abstract: Methods and systems for an injection system are provided. An example injection system includes a container for a pharmaceutical that is sealed at a proximal end with a plunger having a pushing surface for engaging an inner surface of the hollow body. A plunger rod extends axially from the proximal end of the container and is covered with a plunger rod cover. Removal of the cover activates the system and allows for delivery of the pharmaceutical product from the container by advancing the plunger within the container towards the seal.

Abstract: Certain embodiments of 60-sided and 120-sided replacement dice each having a probability distribution equivalent to that of a subject die with fewer faces than the corresponding replacement die such that each replacement die can be used in place of the corresponding subject die.

Abstract: An apparatus to facilitate partitioning of a graphics device is disclosed. The apparatus includes a plurality of engines and logic to partition the plurality of engines to facilitate independent access to each engine within the plurality of engines.

Abstract: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Abstract: An integrated microfabricated alkali vapor cell sensor includes two alkali vapor regions, with a signal path through each. One or two signal emitters, with associated optical signal rotators, such as quarter wave plates, provide circularly polarized input signals into the alkali vapor regions, so that a first signal through the first alkali vapor region is circularly polarized in an opposite direction from a second signal through the second alkali vapor region. Output signals from the two alkali vapor regions are transformed to linearly polarized signals and then measured by one or more signal detectors. A first Larmor frequency is estimated from the output signal from the first alkali vapor region, and a second Larmor frequency is estimated from the output signal from the second alkali vapor region. A heading error-free Larmor frequency is estimated from the first Larmor frequency and the second Larmor frequency.

Abstract: Embodiments of the present disclosure include an apparatus for forming a tubular fitting includes an annular body having an axial height and radial thickness. The apparatus also includes an inner arm forming at least a portion of the annular body, the inner arm positioned at a first end of the annular body with an inner arm thickness that is less than the radial thickness. The apparatus includes an outer arm forming at least a portion of the annular body, the outer arm positioned at a second end of the annular body with an outer arm thickness that is less than the radial thickness. Also, the apparatus includes one or more self-limiting features that control movement of the inner arm and the outer arm relative to one another.

Abstract: A reflector may include an exterior wall, an interior space, one or more interior walls, each interior wall having two ends, a proximal end, and a distal end. Each end of an interior wall may be attached to the exterior wall or to a different interior wall. The interior walls may divide the interior space into two or more sections. The proximal end and the distal end of the reflector may be open. The exterior wall and the interior walls may be configured to reflect light that contacts the exterior wall or interior walls through the distal end of the reflector.

Abstract: Technology is proposed to enable navigating a holographic image. A moving object, such as a hand, is tracked and a gesture is recognized. In response to recognizing the gesture, a virtual shape is created at the location of the recognized gesture. The shape has at least one dimension. The holographic image is moved based on current position of the moving object with respect to the virtual shape.

Abstract: Methods and systems for endpoint detection of lyophilization processes are provided. A method for detecting an endpoint in a lyophilization process includes monitoring a total pressure of gases within a chamber containing a sample undergoing lyophilization and controlling a mass rate of flow of inert gas delivered to the chamber to replace water vapor removed from the chamber. The method further includes determining that sufficient water has been removed from the chamber based on total pressure and mass flow rate of inert gas being delivered.

Abstract: The subject matter discloses a method of composing a video file, comprising receiving a video file having speech from an electronic device used to capture the video file, extracting the speech from the video file and converting the speech to text, analyzing the text to identify breathing points in the text, assigning a start time code and end time code to sections of the text, said sections of the text are defined between two breathing points in the text, and displaying the video file while each section of the sections of the text is displayed between the start time code and end time code associated with the identified breathing points.

Abstract: Embodiments include techniques for static random access memory (SRAM) bitline equalization using phase change material (PCM). The techniques include detecting a defect in SRAM bitlines, and programming a variable resistance PCM cell to offset the detected defect. The techniques also include measuring signal development time for the SRAM bitlines, and adjusting the programming of the variable resistance PCM cell based at least in part on the measured signal development for the SRAM bitlines.

Abstract: A method for protecting a plant from an arthropod may include applying an amount of a repellant composition including diatomaceous earth to a plant. According to some aspects, the repellent composition may render the plant unpalatable to the arthropod, resulting in death of the arthropod by starvation. A method for protecting a plant from an arthropod may include applying an amount of a repellant composition including diatomaceous earth to a plant. The arthropod may not include an exoskeleton, and the repellent composition may render the plant unpalatable to the arthropod, resulting in death of the arthropod by starvation.

Abstract: Microfluidic “organ-on-a-chip” devices have been developed with the aim to replicate human tissues in vitro. However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the “tissue” at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.

Abstract: A golf club includes a golf club head having a body defining an interior cavity. The body includes a sole, a crown and a skirt positioned around a periphery between the sole and crown. A face defines a forward portion of the club head and includes a striking surface width and a hosel defining a hosel bore. A channel and a recessed port are positioned in the sole. The channel extends substantially in a heel-to-toe direction. A sleeve is mounted on a tip end of the golf club shaft and is adapted to be inserted into the hosel bore. A fastener has a shaft portion extending through a passage and a head portion located in the recessed port. Selectively attaching the sleeve adjusts at least one of a loft angle and a lie angle of the club head.

Abstract: A cloud-connected off-grid lighting and video system may include one or more wireless lighting modules and a bridge device to transmit a video stream or images to external devices such as a remote device, a cellular phone, a home automation system, or a security system The cloud-connected off-grid lighting and video system may operate over the cloud via an Internet connection allowing the bridge device to communicate with a server on the Internet that may implement software for the interface to capture data regarding activity detected by the wireless lighting module.

Abstract: A method of making an aerogel is described. The method can include obtaining a solution comprising polyamic acid and an imidazole, adding a dehydrating agent to the solution in an amount where the molar ratio of the imidazole to the dehydrating agent is 0.17:1 to 2.8:1 and reacting the solution at room temperature to 100° C. to produce a polymer matrix gel comprising a polyamic amide, and drying the polymer matrix gel to form an aerogel comprising an open-cell structured polymer matrix that includes 5 wt. % to 50 wt. % of the polyamic amide based on the total weight of the polymer aerogel.