Abstract: In its many embodiments, the present invention provides certain C2-ring-substituted thiadiazine compounds, including compounds Formula (I): (structure represented) or tautomers thereof, and pharmaceutically acceptable salts of said compounds and said tautomers, wherein R1, R4, ring A, RA, m, -L1-, RL, and ring C are as defined herein. The novel compounds of the invention are useful as BACE inhibitors and/or for the treatment and prevention of various pathologies related thereto. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use, including for the possible treatment of Alzheimer's disease, are also disclosed.

Abstract: Systems and methods for processing sample processing devices. The system can include a sample processing device comprising a detection chamber, a motor configured to rotate the sample processing device about an axis of rotation, and an optical module operatively positioned relative to the sample processing device and configured to determine whether a selected volume of material is present in the detection chamber of the sample processing device. The method can include rotating the sample processing device about an axis of rotation, and determining whether a selected volume of material is present in the detection chamber, while rotating the sample processing device. In some embodiments, determining whether a selected volume of material is present can be performed by optically interrogating the detection chamber for an optical property of the material.

Abstract: Aspects of the subject technology relate to a system that analyzes customers' AMI load curves, identifies evening peak users as defined by their load curves, and provides Energy Efficiency (EE) advice related to their periods of high use. For example, identified high evening users can be sent an email with normative comparisons on evening load use, along with tips to reduce energy usage. Other aspects relate to additional targets/communications. Aspects of the subject technology relate to categorizing a user's energy consumption tendencies based on a user's load curve and providing customized content based on the user's category. By taking into consideration the user's actual energy consumption patterns, the system may be able to provide more relevant content to the user.

Abstract: An endoscopic forceps is provided and includes a housing having a shaft that extends therefrom. An end effector assembly is operatively connected to a distal end of the shaft and includes a pair of pivotably coupled first and second jaw members. The jaw members are movable relative to one another. A drive mechanism includes a driving structure. A link assembly includes two or more links that are operably coupled to each other and the drive structure. The two or more links are operably coupled to respective ones of the first and second jaw members.

Abstract: A microfluidic product utilizing gradient surface energy coatings for fluid control comprising a plurality of fluid passages wherein at least one fluid passage comprises a coating configured to control liquid flow wherein the coating configured to control liquid flow comprises a gradient surface energy coating from a proximal location to a distal location on a surface of the fluid passage. The product can include uniform regions and surface gradient regions in the same passage. Coating compositions and product dimensions can be selected to provide control over different flow properties including fluid velocity, reduction and acceleration of fluid flow, and starting and stopping fluid flow.

Abstract: Some embodiments of an infusion pump assembly may be equipped with one or more components to facilitate wireless operation of an infusion pump via a user-operated mobile device. In some embodiments, the mobile device and/or the infusion pump may prompt the user to confirm acceptance of a wirelessly communicated command to prevent an operation by the infusion pump (e.g., a dispensation of medicine) that is not desired by the user.

Abstract: Configurations are described for utilizing light-activated proteins within cell membranes and subcellular regions to assist with medical treatment paradigms, such as hypertension treatment via anatomically specific and temporally precise modulation of renal plexus activity. The invention provides for proteins, nucleic acids, vectors and methods for genetically targeted expression of light-sensitive proteins to specific cells or defined cell populations. In particular the invention provides systems, devices, and methods for millisecond-timescale temporal control of certain cell activities using moderate light intensities, such as the generation or inhibition of electrical spikes in nerve cells and other excitable cells.

Abstract: A messaging system facilitates communication between users through various messaging channels. The messaging system supports multiple communication channels and includes a messaging module that automatically selects one or more of the messaging channels for delivering a message to a recipient of the message using, for example, a set of policy rules or a trained model. The messaging module may also provide, in a user interface for sending and receiving messages, a visual indication of the selected messaging channel to the sender of the message to provide the user with transparency about how the message will be delivered. Additionally, the message may be delivered via multiple messaging channels, where the messaging module may rescind messages from some of the messaging channels upon receiving a reply from the recipient of the message or other confirmation that the recipient has seen the message via one of the communication channels.

Abstract: A method of surgery includes grasping tissue between tissue-contacting surfaces of first and second jaw members of an end effector assembly, supplying energy to at least one of the tissue-contacting surfaces to treat tissue grasped therebetween, and translating and/or manipulating the end effector assembly to cut tissue in a ripping fashion.

Abstract: A gas turbine engine according to an exemplary aspect of the present disclosure includes, among other things, a fan, a compressor section having a low pressure compressor and a high pressure compressor, a combustor section, and a turbine section having a low pressure turbine, the low pressure turbine for driving the low pressure compressor and the fan; a gear reduction effecting a reduction in the speed of the fan relative to a speed of the low pressure turbine and the low pressure compressor; and at least one stage of the compressor section having a ratio of vanes to blades that is greater than or equal to 1.8. The corrected tip speed of the blades is greater than or equal to 480 ft/sec at an approach speed.

Abstract: An electrical submersible pump assembly has a magnetic coupling between the motor shaft and the pump shaft. The coupling includes motor shaft disks mounted to the motor shaft, each having upward and downward facing disk surfaces joined by an outward facing disk cylindrical surface. Motor shaft magnets are mounted in each of the disk cylindrical surfaces and in the upward and downward facing disk surfaces. A pump shaft rotor mounted to the pump shaft has annular bands axially separated from each other by recesses into which the disks extend. Rotor magnets are mounted in each of the recess cylindrical surfaces and in upward and downward facing-band surfaces. The magnets in the recesses interact with the magnets on the disks.

Abstract: Methods and systems are provided for identifying demand at, for example, merchants and ATMs located within selected geographic boundaries, and over a selected time frame. Transaction data for transactions conducted over the selected time frame is received at a computing device, and location data is associated with each of the transactions. The location data generally corresponds to a location at which each of the transactions occurred. The transactions are then grouped into geographic boundaries based on the location data. For each of the geographic boundaries, the transaction data is compared to a predefined benchmark. And, for each of the geographic boundaries satisfying the benchmark, demand indices are generated indicative of financial demand in the geographic boundary.

Abstract: A method for performing linear mixing on coupled Head-related transfer functions (HRTFs) to determine an interpolated HRTF for any specified arrival direction in a range (e.g., a range spanning at least 60 degrees in a plane, or a full range of 360 degrees in a plane), where the coupled HRTFs have been predetermined to have properties such that linear mixing can be performed thereon (to generate interpolated HRTFs) without introducing significant comb filtering distortion. In some embodiments, the method includes steps of: in response to a signal indicative of a specified arrival direction, performing linear mixing on data indicative of coupled HRTFs of a coupled HRTF set to determine an HRTF for the specified arrival direction; and performing HRTF filtering on an audio input signal using the HRTF for the specified arrival direction.

Abstract: The present invention provides compounds of formula (I): compositions comprising such compounds; the use of such compounds in therapy (for example in the treatment or prevention of a disease or condition in which plasma kallikrein activity is implicated); and methods of treating patients with such compounds; wherein R1 to R3, R5 to R9, A, P, V, W, X, Y and Z are as defined herein.

Abstract: Devices and methods that can detect and control an individual polymer in a mixture is acted upon by another compound, for example, an enzyme, in a nanopore are provided. The devices and methods also determine (˜>50 Hz) the nucleotide base sequence of a polynucleotide under feedback control or using signals generated by the interactions between the polynucleotide and the nanopore. The invention is of particular use in the fields of molecular biology, structural biology, cell biology, molecular switches, molecular circuits, and molecular computational devices, and the manufacture thereof.

Abstract: The present invention relates to a notebook computer, comprising a computer main body and a screen movably connected to the computer main body. A cavity and an expansion card press mechanism is provided inside the computer main body. A popup box is further provided on one side of the computer main body. The expansion card press mechanism comprises press blocks capable of moving forward and backward in an installation direction of an expansion card. The press blocks press the expansion card. The cavity is provided with an opening which is disposed at a position on an end face of the computer main body. The popup box is movably connected to the computer main body and provided with an antenna.

Abstract: A system and method for management and processing of resource requests at cache server computing devices is provided. Cache server computing devices segment content into an initialization fragment for storage in memory and one or more remaining fragments for storage in a media having higher latency than the memory. Upon receipt of a request for the content, a cache server computing device transmits the initialization fragment from the memory, retrieves the one or more remaining fragments, and transmits the one or more remaining fragments without retaining the one or more remaining fragments in the memory for subsequent processing.

Abstract: Various structures and methods are disclosed related to routing and programming circuitry on integrated circuits (“IC”) that have arrays of programmable resistive switches. In some embodiments, routing structures utilize densely populated resistive switch arrays to provide for efficient selection circuits that route into and out of logic regions. In other embodiments, programming circuitry is provided to help maintain relatively consistent programming current throughout an array of resistive switches to be programmed. In other embodiments, methods are provided for programming resistive switches without violating given power constraints. These and other embodiments are described further herein.

Abstract: In a process for producing a tetrabromophthalic diester composition, a liquid reaction mixture is prepared comprising tetrabromophthalic anhydride (TBPA), a C2 to C6 polyhydric aliphatic alcohol (PAA) and an alkylene oxide (AO) selected from the group consisting of ethylene oxide and propylene oxide, said reaction mixture being substantially free of an organic solvent. While agitating the reaction mixture, the temperature of the reaction mixture is raised to at least 50° C. to allow the TBPA to react with the PAA and AO to produce a diester composition. The reaction is terminated when the diester composition has an acid value equal to or less than 0.25 mg KOH/gm of the diester composition.

Abstract: In one embodiment, a method includes receiving unstructured text from a user of a social-networking system, determining whether the unstructured text includes a request for a recommendation, identifying one or more first entity names in the unstructured text, generating a structured query based upon the one or more first entity names, identifying, in the social graph, one or more second entity names corresponding to the structured query, and presenting the one or more second entity names and the unstructured text in a social context of the user. The unstructured text may include text of a post or message generated by the user on a social-networking system. A score may be generated based on the unstructured text to determine whether the text includes a request for recommendation using a machine-learning model based on comparison of the unstructured text to the one or more predetermined words associated with requests for recommendation.