Abstract: A method includes wire driven phase in which a plurality of attachments are bonded to teeth, the attachments including a wire-retaining region and an engagement region. The engagement region has a shoulder configured to releasably engage a corresponding indentation in an aligner tray. An archwire is inserted in to the wire-retaining regions to move a first malaccluded tooth from a first position to a second position. An aligner phase follows the wire driven phase, in which the archwire is removed, and an aligner tray is applied over the teeth of the patient. The aligner tray includes cavities shaped to receive and resiliently position the first maloccluded tooth from the second position to a third position, and further includes indentations configured to releasably engage at least a portion of the engagement regions on the attachments.

Abstract: Described herein are compositions and methods for treating inflammatory arthritic conditions tint are effective systemically without causing generalized immunosuppression when administered locally into an inflammatory arthritis-affected joint or a draining lymph node of the arthritis-affected joint of a patient.

Abstract: System and computer-implemented method for monitoring a function model for providing data for at least one function of a computer-controlled machine, in particular an image recognition algorithm.

Abstract: A device for treating heart failure in a patient. The device comprising a body, at least one passage through the body, at least one one way valve in the passage and a mounting means adapted for mounting the body in an opening provided in the patient's atrial septum. In use, the device is oriented such that, when the patient's left atrial pressure exceeds the patient's right atrial pressure by a predetermined amount, the one way valve(s) opens to allow blood flow through the passage(s) from the left atrium to the right atrium to thereby reduce the left atrial pressure.

Abstract: A golf club with a multi-piece adjustable and interchangeable modular hosel system comprises a shaft tip connector portion, an upper hosel portion, and optional, intermediate interchangeable hosel adjustment spacer(s). The modular hosel system can be used, for example, with no spacers in place, or one or more risers in each of the hosel adjustability regions. The adjustment spacers can be used to increase the hosel length and shaft axis to head center of gravity offset or intersection. Angled risers can be oriented to adjust the shaft axis relative to club head orientation to fit and adjust specifications including loft and lie angle, alone or in combination. The modular hosel construction provides a quick and efficient means of fitting the putter specification to a large number of golfer requirements and also adjusting the specifications for changing user needs or course conditions.

Abstract: A system and method for controlling charging of multiple electric vehicles (EVs) arriving at, and departing from, different charging stations at different times, includes scheduling charging of each EV of the multiple EVs responsive to which one of a plurality of categories each EV is assigned, each EV being assigned to one of the categories according to an arrival time at an associated one of the different charging stations, a departure time from the associated one of the different charging stations, an initial state of charge (SoC) of the EV, and a target SoC of the EV, and controlling charging of each EV responsive to the scheduling of charging for the assigned category of each EV. Charging demand may be selected by each EV as being reliable or flexible with flexible charging demand having a minimum target SoC and maximum target SoC.

Abstract: An apparatus, system, and/or method for carrying a power line device from an aircraft, such as an unmanned aerial vehicle (UAV), and for performing work on electrical power lines and/or splices on electrical power lines. The apparatus or system may include an attachment flange selectively and releasably coupled to the aircraft, a payload support frame selectively and releasably coupled to the attachment flange, an intermediary frame selectively and releasably coupled to the payload support frame, and a base frame selectively and releasably coupled to the power line device. The payload support frame may include at least three elongated rigid segments, each including a hollow elongated pole, at least three upper flexible segments, each at an upper end of a corresponding rigid segment, and at least three lower flexible segments, each at a lower end of a corresponding rigid segment.

Abstract: Polyurethanes are made by curing a reaction mixture containing a polyether polyol that contains residues of a zinc hexacyanocobaltate catalyst complex. The reaction mixture contains certain chelating agents in small quantities. The amount of cobalt that is extractable from the polyurethane is reduced.

Abstract: A method for analyzing planar sample is provided. In some cases the method comprises: (a) labelling the planar sample with a capture agent that is linked to a nucleic acid, wherein the capture agent specifically binds to complementary sites in the planar sample; (b) reading a fluorescent signal caused by extension of a primer that is hybridized to the nucleic acid, using fluorescence microscopy. Several implementations of the method, and multiplexed versions of the same, are also provided.

Abstract: One example system comprises a light source configured to emit light. The system also comprises a waveguide configured to guide the emitted light from a first end of the waveguide toward a second end of the waveguide. The waveguide has an output surface between the first end and the second end. The system also comprises a plurality of mirrors including a first mirror and a second mirror. The first mirror reflects a first portion of the light toward the output surface. The second mirror reflects a second portion of the light toward the output surface. The first portion propagates out of the output surface toward a scene as a first transmitted light beam. The second portion propagates out of the output surface toward the scene as a second transmitted light beam.

Abstract: A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.

Abstract: A method is provided for determining one or more tissue boundaries within ultrasound image data of anatomical region. The method is based on generating two separate images from the same input ultrasound data, acquired in a single acquisition event. One image is generated with contrast enhancement, so that boundaries surrounding a fluid-containing region are especially well visible and, the second image is generated without this enhancement, or with a different enhancement so that boundaries surrounding tissue regions are especially well visible. An image segmentation procedure is then applied which uses a combination of both images as input and uses both to determine the boundaries within the imaged regions.

Abstract: A system and a method for navigating an aerial robotic device movable within an aerial movement volume are provided. The method comprises generating a global environment map of the aerial movement volume, and detecting static obstacles therefrom. The method further comprises generating a depth map detailing presence or absence of objects with reference to a current location of the aerial robotic device, and detecting dynamic obstacles therefrom. The method further comprises re-scaling the depth map to correspond to the global environment map of the aerial movement volume, and tracing a route for the aerial robotic device from the current location to the target location avoiding the one or more static obstacles and the one or more dynamic obstacles. The method further comprises navigating the aerial robotic device based on the traced route to enable the aerial robotic device from the current location to the target location.

Abstract: Systems and methods are provided for a helmet having a configurable headband assembly. A helmet includes a helmet liner having a plurality of headband attachment points, each headband attachment point including a first opening for receiving and holding a primary attachment structure; and a second opening for receiving a locking pin. A headband assembly is configured to assist in fitting the helmet to a wearer's head. The headband assembly includes a fit adjustment mechanism configured to adjust an internal shape of the headband assembly; and a plurality of attachment structure sets, an attachment structure set including a primary attachment structure; and a locking pin.

Abstract: The present invention provides for the use of various compositions, including compounds of Formula (I) or (Ia), or a species thereof, and pharmaceutically acceptable salts, stereoisomers, and isotopic forms thereof in treating a proliferative disease such as cancer in a patient. Administration of a compound or pharmaceutical composition at a dose and conforming to a dosing regimen described herein is expected to inhibit cyclin-dependent kinase 7 (CDK7), and thereby, treat the cancer.

Abstract: Devices and methods are disclosed for measuring a target substance concentration in a sample utilizing a biosensor.

Abstract: A clocking technique for reducing the power of PDM microphones in dual microphone systems is disclosed. A clock for a conventional PDM microphone (PDMCLK) is provided by another source. PDM microphones send serial data (PDMDAT) on the rising (“Right”) or falling (“Left”) edge of the PDMCLK clock, depending on how the microphone is configured. In a dual PDM microphone configuration, the microphones alternate sending data on the rising edges (transitions to logic-1) and falling edges (transitions to logic-0) of PDMCLK. Typically, Complementary Metal-Oxide-Semiconductor (CMOS) logic is used to transmit or drive the clock signal to the microphones. CMOS drivers consume power primarily when they transition from a logic-0 to a logic-1 or from a logic-1 to a logic-0. Thus, a free-running clock signal will produce the highest CMOS power consumption.

Abstract: A system for digital rights management including a processor in a platform and a memory device comprising instructions that when executed configure the processor to perform operations. The operations may include determining whether a digital media is locally installed in a platform before initiating an operating system, and launching a first UEFI application configured to generate attestation data and communicate attestation based data to a server through an encrypted medium in response to determining the digital media is not installed. The operations may also include receive a binary file of the digital media and a first decryption key and performing a sealing of the binary file using a sealing enclave of the first UEFI application and generating a local decryption second key based on the first key and local entropy. The operations may also include installing the sealed binary file on local storage.

Abstract: Gaming systems and methods for determining zero, one or more awards based on one or more moveable wild reels associated with an increasing modifier.

Abstract: A method includes identifying one or more images of a mold of a dental arch, identifying a digital model corresponding to the mold of the dental arch, providing the one or more images and the digital model as input into a trained machine learning model, receiving, from the trained machine learning model, output, and determining, based on the output, whether the mold matches the digital model.