Abstract: The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or a fragment thereof directly or indirectly linked by covalence to said conjugate, wherein said conjugate comprises (i) a polypeptide comprising the amino acid sequence of the interleukin 15 or derivatives thereof, and (ii) a polypeptide comprising the amino acid sequence of the sushi domain of the interleukin 15R alpha (IL-15R?) or derivatives thereof; and uses thereof.

Abstract: Water management systems and methods of constructing water management systems comprising two-dimensional arrays of cells. Each cell has a base and a cell top module stacked on the base, the cell top module having a top flange and at least one top leg, a lower end of which engages the base. A base of one system has a bottom leg with an upper end cavity configured for a lateral clearance fit of a lower end portion of the top leg. The cavity holds at least one stacked spacer and is filled with a flowable substance after the top leg is inserted and positioned on the spacer. The flowable substance hardens to fully seat the lower end portion of the upper leg. Another system series of the cell top flanges being held together by tension cables extending therethrough.

Abstract: A system for subatmospheric pressure therapy in connection with healing a wound is provided. The system includes a wound dressing cover dimensioned for positioning relative to a wound bed of a subject to establish a reservoir over the wound bed in which subatmospheric pressure may be maintained, a subatmospheric pressure mechanism including, a housing, a vacuum source disposed in the housing, and a collection canister in fluid communication with the vacuum source. The system further includes an exudate conduit in fluid communication with the wound dressing and the collection canister for collecting exudate removed from the reservoir and deposited in the collection canister under influence of the vacuum source and a vent conduit in fluid communication with the collection canister and the wound dressing for introducing air into the reservoir to facilitate flow of exudate through the exudate conduit.

Abstract: Systems, methods, and computer-readable media for communicating electronic device secure element data over multiple paths for online payments are provided. In one example embodiment, a method includes, inter alia, at a commercial entity subsystem, receiving, from an electronic device, device transaction data that includes credential data indicative of a payment credential on the electronic device for funding a transaction with a merchant subsystem, accessing a transaction identifier, deriving a transaction key based on transaction key data that includes the accessed transaction identifier, transmitting, to one of the merchant subsystem and the electronic device, merchant payment data that includes a first portion of the credential data and the accessed transaction identifier, and sharing, with a financial institution subsystem using the transaction key, commercial payment data that includes a second portion of the credential data that is different than the first portion of the credential data.

Abstract: Provided herein are blends of benzoxazine-containing monomers with polymer having one or more leaving groups, such as tosylated polymers (e.g., tosylated polyethylene glycol (PEG)); or blends of benzoxazine-containing monomers with particles/fibers having one or more leaving groups.

Abstract: Methods and apparatuses including a patellar implant are disclosed. The patellar implant can include a member, an articulation component and a connection mechanism. The member can be configured to engage a osteotimized surface of a patella. The articulation component can have an articulation surface that can be configured to articulate with a femoral prosthesis along a patellar groove. The connection mechanism can connect the articulation component with the member and can be configured to allow for at least one of removal and translational movement of the articulation component relative to the member and patella.

Abstract: Portable asphalt reclaimer having a pivotable lid with an integral heating element, and an asphalt holding chamber containing a grate. Asphalt may be reclaimed by placing asphalt chunks on the grate, heating them from above using the heating element in the lid until asphalt falls through the holes in the grate. The asphalt may be removed through a lower door. The pivotable lid may be detachable to separately heat the ground surface to which asphalt is to be applied.

Abstract: The present invention provides an apparatus for conducting an assay in a microfluidic system comprising magnetic beads, said apparatus comprising: a platform upon which a microfluidic system can be mounted, one or more actuators having a magnet, configured to directly influence movement of magnetic beads housed within a microfluidic system when a microfluidic system is mounted on said platform, and a control means configured to control relative movement of the one or more magnets, and a microfluidic system when mounted, to enable the magnet to trace a desired path across a mounted microfluidic system, said magnet being positionable at any x- and y-coordinates of a mounted microfluidic system, wherein said apparatus further comprises: a) at least one rotary actuator configured to enable magnet movement in an x-axis, and/or b) a means for moving a mounted microfluidic system in a stepwise fashion.

Abstract: A system for tracking a location of a body-worn tracking device (BWTD) includes a global navigation satellite system (GNSS) component, one or more sensors, one or more processors, and a memory device. The memory device includes instructions that, when executed by the one or more processors, cause the one or more processors to determine whether a current location of the BWTD can be determined using the GNSS component. The instructions also cause the one or more processors to determine, based in part on the activity of the wearer of the BWTD and based on a determination that the current location of the BWTD cannot be determined using the GNSS component, whether to perform an action. The instructions also cause the one or more processors to perform the action in response to a determination to perform the action.

Abstract: Systems and methods for selectively transmitting routing information between separated local area network (LAN) interfaces are disclosed. In exemplary embodiments, a network appliance to update a local routing table with IP subnet, neighbor type, source type, and community identifier of a second network appliance; based at least on the local routing table, receive a customized routing policy and subnet exporting policy that permits the network appliance to export a subset of IP addresses from the local routing table to a permitted community of network appliances, wherein the customized routing policy and subnet exporting policy are configured by a network administrator of the network appliance; match the permitted community of network appliances to a new community identifier of a third network appliance; and export the subset of IP addresses of the local routing table to the third network appliance based on the customized routing policy and subnet exporting policy.

Abstract: A battery includes a cathode with a metal halide and an electrically conductive material, wherein the metal halide acts as an active cathode material; a porous silicon anode with a surface having pores with a depth of about 0.5 microns to about 500 microns, and a metal on the surface and in at least some of the pores thereof; and an electrolyte contacting the anode and the cathode, wherein the electrolyte includes a nitrile moiety.

Abstract: Methods and systems for managing attribute data for shipping and handling within a retail supply chain are disclosed. Item attributes of new items are recorded upon first receipt at a distribution center and are stored in a local database. This attribute data is synchronized to a centralized database. Data from the centralized database is pushed out to other distribution centers. The use of a centralized database of item attributes streamlines the process of inputting data for new items. This database is accessible by multiple systems with the supply chain to determine how the items should be processed. A pathfinding system utilizes item attribute data and facility data to determine a processing route for each item passing through a distribution facility.

Abstract: Articles and intermediates are described comprising an organic polymeric base member and a hardcoat layer disposed on the organic polymeric base member, wherein the hardcoat layer can be stretched 25-75% without cracking. A siliceous layer is disposed on the hardcoat layer. The siliceous layer has a porosity of no greater than 10% and a thickness no greater than 1 micron. In some embodiments, the article further comprises a surface layer comprising a zwitterionic compound bonded to the siliceous layer.

Abstract: A deep neural network(s) (DNN) may be used to detect objects from sensor data of a three dimensional (3D) environment. For example, a multi-view perception DNN may include multiple constituent DNNs or stages chained together that sequentially process different views of the 3D environment. An example DNN may include a first stage that performs class segmentation in a first view (e.g., perspective view) and a second stage that performs class segmentation and/or regresses instance geometry in a second view (e.g., top-down). The DNN outputs may be processed to generate 2D and/or 3D bounding boxes and class labels for detected objects in the 3D environment. As such, the techniques described herein may be used to detect and classify animate objects and/or parts of an environment, and these detections and classifications may be provided to an autonomous vehicle drive stack to enable safe planning and control of the autonomous vehicle.

Abstract: Described are coordinated apparatus and methods for drug targeting, clearing the lumen, placing implants within the wall of, and stenting, as necessary, any tubular anatomical structure with single luminal entry. Miniature balls, or miniballs, are introduced into the wall aeroballistically from within the lumen, or small arcuate bands called stays inserted through the outer tunic by means of a hand tool. When miniballs must be placed too closely together to be controlled by hand, a positional control system assists in discharge. Implantation within or proximal to diseased tissue targeting, and thus concentrating the medication in that tissue, miniballs and stays can be used to deliver and controllably release multiple drugs, a radionuclide, or an open or closed loop smart-pill, for example. A glossary of terms follows the specification. Balance of abstract appended to the section entitled Summary of the Invention.

Abstract: Disclosed is a system and method for optimization of data transfer to a software service. In exemplary embodiments, a computer-implemented method for determining a transit appliance for data traffic to a software service through one or more interconnected networks comprising a plurality of network appliances, comprises determining performance metrics for each of the plurality of network appliances to at least one IP address associated with the software service, and selecting a transit appliance for data transfer to the IP address, the selected transit appliance based at least in part on the performance metrics.

Abstract: A system determines that a given drive in an array is due for replacement. The system ranks available replacement drives based on their predicted rates of failure. The system replaces the given drive with a replacement drive that has the lowest predicted rate of failure.

Abstract: The present invention relates to bicyclic heteroaromatic urea or carbamate compounds of formula I where the variables are as defined in the claims and the description. The invention moreover relates to a pharmaceutical composition containing these compounds I, and to these compounds for use in therapy, especially for use in the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularization.

Abstract: A turbine shroud assembly for use with a gas turbine engine includes a blade track segment coupled to a carrier segment, and a sheet-metal seal that seals therebetween. The blade track segment includes a shroud wall that extends circumferentially partway around an axis and an attachment feature that extends radially outward from the shroud wall. The carrier is coupled with the attachment feature to support the blade track segment.

Abstract: A method that includes obtaining, by an application executing on a computing system, a list of properties defining at least one property. The executing application writes an uncompiled class definition implementing a compiled interface and writes one or more properties of the compiled interface into the uncompiled class definition. The executing application writes the at least one property and at least one serialization attribute into the uncompiled class definition. The executing application causes the uncompiled class definition to be compiled, loads the compiled class definition, and creates an object by instantiating the compiled class definition. The object is serializable. The executing application may reflect on the compiled interface to obtain the one or more properties. Each of the one or more properties is strongly typed.