Abstract: The disclosure provides compositions and methods for the selective targeting of components of a first or a second DNA repair pathway in cancer cells having an impaired, defective or deregulated first DNA repair pathway. In some embodiments of the disclosure, the disclosure provides a composition comprising a DNA ligase 1 (LIG1) blocking agent, wherein in a target cell comprising an impaired, defective or deregulated homologous recombination (HR) repair pathway, the blocking agent reduces or inhibits a function of LIG1. In some embodiments of the disclosure, the disclosure provides composition comprising a Fanconi Anemia Group M protein (FANCM) blocking agent, wherein in a target cell comprising an impaired, defective or deregulated homologous recombination (HR) repair pathway, the blocking agent reduces or inhibits a function of FANCM. The disclosure further provides methods for using compositions of the disclosure for the treatment of cancer.

Abstract: A method includes deploying a logging tool in a borehole formed in a subsurface formation, the logging tool having a transmitter and a receiver, wherein a condition that is present during logging comprises at least one of a shape of the borehole is non-circular and the logging tool is off-center within the borehole. The method includes emitting, by the transmitter, a signal into subsurface formation and detecting, by the receiver, a response to the signal being propagated through the subsurface formation. The method includes creating, from the response, a borehole image that includes features in the subsurface formation and correcting the features, wherein correcting the features comprises mapping points of a non-circular shape in the borehole image into a plane substantially perpendicular to an axis of the borehole.

Abstract: Auxiliary system for a low-temperature remote thermal energy distribution network (anergy network) connected to user thermal installations, comprising one or more heat pumps thermally coupled to the anergy network via a heat exchanger, one or more air-liquid heat exchangers thermally coupled to the outside air, and a hydraulic network interconnecting the heat pumps to the heat exchanger of the anergy network, at least one of the heat pumps being a liquid-air heat pump fluidically connected by the hydraulic network to at least one of said air-liquid heat exchangers. The auxiliary system further comprises a measurement, control and regulation (MCR) system. The hydraulic network comprises valves controlled by the MCR system and a hydraulic circuit configured to allow direct connection of said air-liquid heat exchangers to the heat exchanger of the anergy network.

Abstract: A method for imaging a downhole formation. The method includes combining the captured images to generate a partial image of the formation, wherein the partial image includes captured images separated by gaps representing portions of the formation not captured with sensors what were disposed downhole. The method includes locating dips in the formation within the partial image and interpolating the partial image using the located dips within the partial image.

Abstract: A method for identifying a shape of a borehole may comprise disposing a downhole tool into the borehole, wherein the downhole tool comprises at least one transducer, transmitting a pressure pulse from the at least one transducer, wherein the pressure pulse is reflected as an echo, recording the echo with the at least one transducer, producing data points based at least in part on the echo, each data point including a radial distance value and an azimuthal value corresponding to the radial distance value, performing a pre-selection, fitting a geometric shape to a plurality of data points within the borehole, and sorting out at least one of the plurality of data points based at least in part on the shape. A system for identifying shape of a borehole may comprise at least one transducer and an information handling system.

Abstract: A method includes deploying a logging tool in a borehole formed in a subsurface formation, the logging tool having a transmitter and a receiver, wherein a condition that is present during logging comprises at least one of a shape of the borehole is non-circular and the logging tool is off-center within the borehole. The method includes emitting, by the transmitter, a signal into subsurface formation and detecting, by the receiver, a response to the signal being propagated through the subsurface formation. The method includes creating, from the response, a borehole image that includes features in the subsurface formation and correcting the features, wherein correcting the features comprises mapping points of a non-circular shape in the borehole image into a plane substantially perpendicular to an axis of the borehole.

Abstract: A method includes deploying a logging tool in a borehole formed in a subsurface formation. The logging tool has a transmitter and a receiver. The method includes emitting, by the transmitter, a signal into subsurface formation. The method includes detecting, by the receiver, a response to the signal being propagated through the subsurface formation. The method includes creating, from the response, a borehole image that includes distorted features representing bedding dips in the subsurface formation. The method includes correcting the distorted features, wherein correcting the distorted features comprises mapping points of a non-circular shape in the borehole image to points on a circular shape.

Abstract: A method for imaging a downhole formation. The method includes combining the captured images to generate a partial image of the formation, wherein the partial image includes captured images separated by gaps representing portions of the formation not captured with sensors what were disposed downhole. The method includes locating dips in the formation within the partial image and interpolating the partial image using the located dips within the partial image.

Abstract: A method includes deploying a logging tool in a borehole formed in a subsurface formation. The logging tool has a transmitter and a receiver. The method includes emitting, by the transmitter, a signal into subsurface formation. The method includes detecting, by the receiver, a response to the signal being propagated through the subsurface formation. The method includes creating, from the response, a borehole image that includes distorted features representing bedding dips in the subsurface formation. The method includes correcting the distorted features, wherein correcting the distorted features comprises mapping points of a non-circular shape in the borehole image to points on a circular shape.

Abstract: A method for identifying a shape of a borehole may comprise disposing a downhole tool into the borehole, wherein the downhole tool comprises at least one transducer, transmitting a pressure pulse from the at least one transducer, wherein the pressure pulse is reflected as an echo, recording the echo with the at least one transducer, producing data points based at least in part on the echo, each data point including a radial distance value and an azimuthal value corresponding to the radial distance value, performing a pre-selection, fitting a geometric shape to a plurality of data points within the borehole, and sorting out at least one of the plurality of data points based at least in part on the shape. A system for identifying shape of a borehole may comprise at least one transducer and an information handling system.

Abstract: An integrated acoustic and induction logging tool enables efficient logging operations and reduces logging string length. In some of the disclosed embodiments, an integrated acoustic and induction logging tool includes a mandrel compatible with acoustic logging operations and induction logging operations. The integrated acoustic and induction logging tool also includes an acoustic logging transducer set and an induction logging coil set, where a plurality of transducers of the acoustic logging transducer set are interspersed among a plurality of coils of the induction logging coil set along the mandrel. A related assembly method includes obtaining a mandrel compatible with acoustic logging and induction logging. The method also includes assembling an acoustic logging transducer set and an induction logging coil set along the mandrel, where a plurality of transducers of the acoustic logging transducer set are interspersed among a plurality of coils of the induction logging coil set along the mandrel.

Abstract: An illustrative method of determining water-filled porosity of a formation that includes acquiring a downhole temperature, acquiring a total porosity of the formation, acquiring a dielectric measurement of the formation, determining a water salinity based on the temperature, total porosity, and dielectric measurement. The method further includes determining a water-filled porosity of the formation based at least in part on the water salinity.

Abstract: An integrated acoustic and induction logging tool enables efficient logging operations and reduces logging string length. In some of the disclosed embodiments, an integrated acoustic and induction logging tool includes a mandrel compatible with acoustic logging operations and induction logging operations. The integrated acoustic and induction logging tool also includes an acoustic logging transducer set and an induction logging coil set, where a plurality of transducers of the acoustic logging transducer set are interspersed among a plurality of coils of the induction logging coil set along the mandrel. A related assembly method includes obtaining a mandrel compatible with acoustic logging and induction logging. The method also includes assembling an acoustic logging transducer set and an induction logging coil set along the mandrel, where a plurality of transducers of the acoustic logging transducer set are interspersed among a plurality of coils of the induction logging coil set along the mandrel.

Abstract: The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).

Abstract: The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).

Abstract: The present invention relates in some aspects to super-enhancers and related compositions, methods, and agents that are useful for modulating expression of cell type-specific genes that are required for maintenance of cell identity (e.g., embryonic stem cell identity) or maintenance of a disease state (e.g., cancer).

Abstract: A bag for carrying at least one hockey stick and at least one other item, the bag having an enclosure adapted to transport the at least one other item and at least a first closable opening in the enclosure to insert the at least one other item therein. A hockey stick pocket is located on and integral with an outer surface of the enclosure and is composed of a straight elongated section connected to a head section at an angle so as to mimic the shape of the at least one hockey stick. The hockey stick pocket has at least a second closable opening so as to allow insertion of the at least one hockey stick therein.