Abstract: Methods of detecting, preventing, treating, controlling or managing progressive neurodegenerative diseases are provided. These methods comprise the administration of antibodies that reduce or eliminate monocytes that abnormally express Astrotactin (ASTN1), or block blood monocytes that abnormally express ASTN1 from migrating to the central nervous system. Also provided are pharmaceutical compositions that comprise antibodies that specifically target the extracellular domain (ECD2) of ASTN1 for the prevention, treatment, control or management of progressive neurodegenerative diseases.

Abstract: A computer-implemented method and system for protecting a host computer in a computer network from security threats uses local security-relevant data for the host computer, as well as global security-relevant data for other components in the computer network downloaded from a security information plane system to the host computer, to determine a security threat to the host computer. When a security threat is determined to be a legitimate threat, a security alert is issued, and then an action is initiated in response to the security alert.

Abstract: Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.

Abstract: System and method for performing a remote attestation for creation of a trusted execution environment (TEE) using a virtual secure enclave device running in a virtualized environment utilizes a trusted bootloader appliance in a TEE virtual computing instance, which is created in response to a request for a TEE from a software process running in the system. The trusted bootloader appliance manages the provisioning of a TEE in the TEE virtual computing instance for the software process. The remote attestation includes performing a first stage attestation on the trusted bootloader appliance by a hardware platform of the computer system and performing a second stage attestation on the provisioned TEE by the trusted bootloader appliance.

Abstract: System and method for managing security-relevant information in a computer network uses a security information plane (SIP) manager to which different types of security-relevant data are uploaded from components in the computer network and from which networkwide aggregated security information produced from the security-relevant data is download to a global security controller. The downloaded networkwide aggregated security information is used by the global security controller to control security applications running in the computer network.

Abstract: Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.

Abstract: Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.

Abstract: Methods of detecting, preventing, treating, controlling or managing progressive neurodegenerative diseases are provided. These methods comprise the administration of antibodies that reduce or eliminate monocytes that abnormally express Astrotactin (ASTN1), or block blood monocytes that abnormally express ASTN1 from migrating to the central nervous system. Also provided are pharmaceutical compositions that comprise antibodies that specifically target the extracellular domain (ECD2) of ASTN1 for the prevention, treatment, control or management of progressive neurodegenerative diseases.

Abstract: A system and method may be provided to receive sample RNA reads from patients and generate lists of genes and their associated RNA expression levels in each patient. Some of the RNA reads may be matched to an RNA transcript or gene or gene family in terms of their match likelihood and other RNA reads may be matched to an RNA transcript or gene or gene family through the use of one or more machine learning classifiers. A machine learning classifier may be trained based on the plurality of the lists and a plurality of corresponding patients' clinical status data to identify gene patterns that recur with a high degree of frequency in the plurality of the lists. Those gene patterns can be capable of modifying a disease or treatment response and can be targeted for drug/treatment development.

Abstract: System and method for creating and managing trusted execution environments (TEEs) using different underlying hardware TEE mechanisms use a virtual secure enclave device which runs in a virtualized environment in a computer system. The device enables an enclave command transmitted to the virtual secure enclave device to be retrieved and parsed to extract an enclave operation to be executed. A TEE backend module is used to interact with a particular hardware TEE mechanism among those available in the computer system. The module ensures the enclave operation for the software process is executed by the particular hardware TEE mechanism, or the TEE scheme based on a particular hardware TEE mechanism.

Abstract: System and method for providing trusted execution environments uses a peripheral component interconnect (PCI) device of a computer system to receive and process commands to create and manage a trusted execution environment for a software process running in the computer system. The trusted execution environment created in the PCI device is then used to execute operations for the software process.

Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.

Abstract: A computer-implemented method and system for protecting a host computer in a computer network from security threats uses local security-relevant data for the host computer, as well as global security-relevant data for other components in the computer network downloaded from a security information plane system to the host computer, to determine a security threat to the host computer. When a security threat is determined to be a legitimate threat, a security alert is issued, and then an action is initiated in response to the security alert.

Abstract: System and method for managing security-relevant information in a computer network uses a security information plane (SIP) manager to which different types of security-relevant data are uploaded from components in the computer network and from which networkwide aggregated security information produced from the security-relevant data is download to a global security controller. The downloaded networkwide aggregated security information is used by the global security controller to control security applications running in the computer network.

Abstract: System and method for providing secure execution environments in a computer system uses an enclave virtual computing instance to create a secure execution environment, which is deployed in response to a request for such a secure execution environment for content from a software process running in the computer system.

Abstract: On a motorized vehicle with handlebars and handlebar mounted levers, a motorcycle lever retention system includes a button operatively connected to and capable of toggling a rocker switch, a clutch or brake lever having a retracted position and an extended, biased position, a clutch or brake operatively connected to the clutch or brake lever such that the clutch is disengaged or the brake is engaged when the clutch or brake lever is moved into the retracted position, and a mechanism operatively attached to the rocker switch and configured such that when the button is pressed, the rocker switch is toggled causing the mechanism to prevent the clutch from being engaged or the brake from being disengaged and the clutch or brake lever from moving back into the extended, biased position until the button is pressed again.

Abstract: On a motorized vehicle with handlebars and handlebar mounted levers, a motorcycle lever retention system includes a button operatively connected to and capable of toggling a rocker switch, a clutch or brake lever having a retracted position and an extended, biased position, a clutch or brake operatively connected to the clutch or brake lever such that the clutch is disengaged or the brake is engaged when the clutch or brake lever is moved into the retracted position, and a mechanism operatively attached to the rocker switch and configured such that when the button is pressed, the rocker switch is toggled causing the mechanism to prevent the clutch from being engaged or the brake from being disengaged and the clutch or brake lever from moving back into the extended, biased position until the button is pressed again.

Abstract: On a motorized vehicle with handlebars and handlebar mounted levers, a device includes a collar or clamp on which a thumb lever and catch slide in a groove to a desired position and are restrained by a notch, detent, slot, or other disruption in the groove to retain a handlebar lever in a desired position. Preferably, the thumb and catch are biased toward a disengaged position by a spring, by gravity, or by electro mechanical means. Spacers, additions, and handlebar extensions can all be provided with the device to allow for installation on a variety of handlebar sizes. In another embodiment, the thumb lever pivots about an axis generally perpendicular from the handlebar axis between a disengaged positon where the catch is clear from the clutch or brake lever and an engaged position where the catch engages the clutch or brake lever and holds it in a retracted position.

Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.

Abstract: The present invention provides synthetic rodent antibody libraries, such as mouse or rat antibody libraries, as well as polypeptides, nucleic acids, vectors, host cells and methods used in conjunction with these libraries. The present invention also provides antibodies isolated from such libraries and variants of such antibodies.