Patents by Inventor David Oupicky

David Oupicky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHLOROQUINE-BASED MATERIALS FOR THE TREATMENT OF DISEASES
    Publication number: 20210161825
    Abstract: Provided herein are copolymers comprising a plurality of a first monomer and a plurality of a second monomer, wherein chloroquine, hydroxychloroquine, or a chloroquine analog is appended to at least a portion of the plurality of the first monomer. Also provided are nanoparticles comprising copolymers as described herein, and methods of using the copolymers and nanoparticles for treating diseases or disorders, e.g., Inflammatory Bowel Disease (IBD) or cancer (e.g., colon cancer).
    Type: Application
    Filed: April 12, 2019
    Publication date: June 3, 2021
    Inventors: David Oupicky, Fei Yu
  • Polyamine Prodrugs And Polyamine Prodrug Formulations
    Publication number: 20200390896
    Abstract: Provided herein are copolymers comprising monomers of a polyamine and a degradable linker, and further comprising a stabilizing moiety, a fluorinated moiety, a poly(ethylene glycol) (PEG) which is optionally substituted with a targeting moiety, or a combination thereof. Also provided are nanoparticles comprising copolymers as described herein, and methods of using the copolymers and nanoparticles for treating diseases or disorders, e.g., Snyder Robinson Disease or cancer.
    Type: Application
    Filed: March 6, 2019
    Publication date: December 17, 2020
    Inventor: David Oupicky
  • CXCR4 INHIBITING CARRIERS FOR NUCLEIC ACID DELIVERY
    Publication number: 20170216445
    Abstract: The present invention generally relates to carriers including polymers and lipids that comprise a CXCR4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a CXCR4 inhibiting moiety. These carriers can be suitable for delivery of nucleic acids to cells. These carriers and pharmaceutical compositions comprising these carriers can be used to treat various conditions including cancers and inflammation conditions.
    Type: Application
    Filed: January 11, 2017
    Publication date: August 3, 2017
    Inventors: David Oupicky, Jing Li
  • CXCR4 inhibiting carriers for nucleic acid delivery
    Patent number: 9545453
    Abstract: The present invention generally relates to carriers including polymers and lipids that comprise a CXCR4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a CXCR4 inhibiting moiety. These carriers can be suitable for delivery of nucleic acids to cells. These carriers and pharmaceutical compositions can be used to treat various conditions including cancers and inflammation conditions.
    Type: Grant
    Filed: October 15, 2012
    Date of Patent: January 17, 2017
    Assignee: Wayne State University
    Inventors: David Oupicky, Jing Li
  • CXCR4 INHIBITING CARRIERS FOR NUCLEIC ACID DELIVERY
    Publication number: 20140243397
    Abstract: The present invention generally relates to carriers including polymers and lipids that comprise a CXCR4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a CXCR4 inhibiting moiety. These carriers can be suitable for delivery of nucleic acids to cells. These carriers and pharmaceutical compositions can be used to treat various conditions including cancers and inflammation conditions.
    Type: Application
    Filed: October 15, 2012
    Publication date: August 28, 2014
    Inventors: David Oupicky, Jing Li