Abstract: Disclosed are dendrimers of formula (I): and pharmaceutically acceptable salts thereof. Also disclosed are pharmaceutical compositions comprising the dendrimer of formula (I) and methods of using the same for treating cancer.

Abstract: This application relates to improvements in environments for microbial testing. Exemplary embodiments provide a uniquely configured tray containing an environment conditioning material, such as an oxygen scavenger material, for use with a cassette assembly. Furthermore, some embodiments provide a cutting mechanism that allows the tray to be reliably breached, thereby exposing the material inside to the environment. Some embodiments can cut open the material with specially-configured cutter teeth, which can easily be deployed by twisting or pushing two halves of the cassette assembly.

Abstract: This application relates to improvements in environments for microbial testing. Exemplary embodiments provide a uniquely configured tray containing an environment conditioning material, such as an oxygen scavenger material, for use with a cassette assembly. Furthermore, some embodiments provide a cutting mechanism that allows the tray to be reliably breached, thereby exposing the material inside to the environment. Some embodiments can cut open the material with specially-configured cutter teeth, which can easily be deployed by twisting or pushing two halves of the cassette assembly.

Abstract: A handleset includes a housing, a spindle sleeve, a handle, a coupler, and a spindle. The spindle sleeve includes an aperture, and is rotatably mounted to the housing. The handle is mounted to the spindle sleeve and includes a recess aligned with the aperture. The coupler is movably mounted in the aperture for movement between a decoupling position and a coupling position. The coupler in the coupling position is disengaged from the recess and does not prevent removal of the handle from the spindle sleeve. The coupler in the coupling position extends into the recess and prevents removal of the handle from the spindle sleeve. The spindle is movably received in the spindle sleeve and selectively retains the coupler in the coupling position.

Abstract: A wafer shape metrology system includes a wafer shape metrology sub-system configured to perform one or more stress-free shape measurements on a first wafer, a second wafer, and a post-bonding pair of the first and second wafers. The wafer shape metrology system includes a controller communicatively coupled to the wafer shape metrology sub-system. The controller is configured to receive stress-free shape measurements from the wafer shape sub-system; predict overlay between one or more features on the first wafer and the second wafer based on the stress-free shape measurements of the first wafer, the second wafer, and the post-bonding pair of the first wafer and the second wafer; and provide a feedback adjustment to one or more process tools based on the predicted overlay. Additionally, feedforward and feedback adjustments may be provided to one or more process tools.

Abstract: The present document relates to methods and apparatus for rendering input audio for playback in a playback environment. The input audio includes at least one audio object and associated metadata, and the associated metadata indicates at least a location of the audio object. A method for rendering input audio including divergence metadata for playback in a playback environment comprises creating two additional audio objects associated with the audio object such that respective locations of the two additional audio objects are evenly spaced from the location of the audio object, on opposite sides of the location of the audio object when seen from an intended listener's position in the playback environment, determining respective weight factors for application to the audio object and the two additional audio objects, and rendering the audio object and the two additional audio objects to one or more speaker feeds in accordance with the determined weight factors.

Abstract: A system for emitting light (such as a luminaire) includes a first light emitting diode (LED) string and a first LED driver that is electrically connected in parallel to the first LED string. The system also may include a second (or more) LED string(s), each associated with an additional LED driver. One-way conductors and normally-open switches are used so that if one LED driver fails, the remaining LED driver(s) will deliver power to the failed driver's LED string so that the light remains operational, but with a reduced brightness.

Abstract: The invention relates to compounds of formula I wherein R1, R2 and - - - - - are as defined herein, pharmaceutical compositions comprising the compounds and methods of treating COVID-19 in a patient by administering therapeutically effective amounts of the compounds and methods of inhibiting or preventing replication of SARS-CoV-2 with the compounds.

Abstract: Table grape plants exhibiting reduced berry browning are provided, together with methods of producing, identifying, or selecting plants or germplasm with a reduced berry browning phenotype. Such plants include table grape plants comprising introgressed genomic regions conferring a reduction in berry browning. Compositions, including novel polymorphic markers for detecting plants comprising introgressed berry browning reduction alleles, are further provided.

Abstract: Portable, hand held, battery operated, hydraulic tools are provided with a tool frame and one or more interchangeable working heads. When the working head is connected with the tool frame, a piston actuated by a hydraulic system within the tool frame applies force to the working head to perform a task. The tool includes a sensor for detecting the type of head connected with the tool and a mechanism for adjusting the amount of force applied to the head by the hydraulic system based on the detected head type.

Abstract: Disclosed embodiments are directed to quad track skid-steer loaders and power machines having a frame, a cab, and a lift arm assembly pivotally coupled to the frame rearward of at least a portion of the cab and extending forward of the frame. A first axle assembly and a second axle assembly on a first side of the frame mount first and second track assemblies. A third axle assembly and a fourth axle assembly on a second side of the frame mount third and fourth track assemblies. A first drive motor rotates the first and second axles to drive the first and second track assemblies and a second drive motor rotates the third and fourth axles to drive the third and fourth track assemblies.

Abstract: The invention generally relates to products for use in the treatment and/or prevention of Pulmonary Arterial Hypertension (PAH). More specifically, the invention relates to translocator protein (TSPO) binding members which treat or prevent pulmonary endothelial cell dysfunction, and the use of such TSPO binding members for use in the treatment and/or prevention of PAH [FIG. 1].

Abstract: The present disclosure provides peptoid-based chelating ligands, corresponding cyclic peptoids, and methods of making thereof. Functional groups may be tailored for high metal binding affinity and selectivity. The side chains of a cyclic peptoid according to the present disclosure may be selected based on, for example, high affinity for actinide or other metal ions, selectivity for actinide or other metal ions, the ability to recover a metal once it is bound to the peptoid, and whether the overall peptoid should be hydrophobic or hydrophilic. Unlike siderophores, peptoid-based chelating ligands of the present disclosure are not readily hydrolyzed under physiological conditions. Therefore, peptoid-based chelating ligands may be, for example, used to treat actinide (e.g., iron and lead) poisoning in vivo. Moreover, peptoid-based chelating ligands of the present disclosure may be used for medical imaging, chelation therapy, drug delivery, and separation technologies, for example.

Abstract: An information technology (IT) network includes configuration items (CIs) that may constantly change, where the CIs describe hardware components or software components that are configured to operate on the IT network. Machine learning techniques can be employed determine whether a CI has been changed (e.g., added, updated, or removed) in the IT network. For example, a software code or a log message associated with a CI can be analyzed to determine whether the CI is a newly added or updated within the IT network.

Abstract: Methods for dynamically evaluating blood flow are provided. The method may include injecting Indocyanine Green (ICG) into the bloodstream of a patient, such that the ICG perfuses into a tissue of the patient. ICG images of the tissue may be recorded and stored, such that a user may select a range of stored ICG images. Data indicative of the selected range of stored ICG images is automatically normalized and background-filtering, and a dynamic representation of the ICG perfusion may be generated as a function of time based on the normalized and filtered data. As such, a clinical decision may be made based on the dynamic representation of the ICG perfusion.

Abstract: A wafer shape metrology system includes a wafer shape metrology sub-system configured to perform one or more stress-free shape measurements on a first wafer, a second wafer, and a post-bonding pair of the first and second wafers. The wafer shape metrology system includes a controller communicatively coupled to the wafer shape metrology sub-system. The controller is configured to receive stress-free shape measurements from the wafer shape sub-system; predict overlay between one or more features on the first wafer and the second wafer based on the stress-free shape measurements of the first wafer, the second wafer, and the post-bonding pair of the first wafer and the second wafer; and provide a feedback adjustment to one or more process tools based on the predicted overlay. Additionally, feedforward and feedback adjustments may be provided to one or more process tools.

Abstract: An information technology (IT) network includes configuration items (CIs) that may constantly change, where the CIs describe hardware components or software components that are configured to operate on the IT network. A system comprising a server can determine a change associated with a CI, send, to a configuration management database (CMDB), a message that updates the CMDB based on the determined change associated with the CI, determine, for the CI, a monitor configuration that describes one or more variables and corresponding one or more parameters with which the CI is to be monitored, and send the CI with the monitor configuration to a plurality of monitoring software tools operating on a plurality of servers, where each monitoring software tool is configured to monitor the CI based on the monitor configuration.

Abstract: A logic circuitry package for a replaceable print apparatus component comprises an interface to communicate with a print apparatus logic circuit, and at least one logic circuit. The logic circuit may be configured to identify, from a command stream received from the print apparatus, parameters including a class parameter, and/or identify, from the command stream, a read request, and output, via the interface, a count value in response to a read request, the count value based on identified received parameters.