Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: A patient control system uses a patient-implanted catheter in thermal communication with a fluid bath via a circulating fluid circuit. A controller automatically controls the temperature of the fluid bath as required for selectively cooling or heating the patient in accordance with patient temperature measurements. The controller thermally decouples the catheter and patient from the fluid bath during changes in fluid bath temperatures in order to overcome the effects of system thermal mass.

Abstract: A patient control system uses a patient-implanted catheter in thermal communication with a fluid bath via a circulating fluid circuit. A controller automatically controls the temperature of the fluid bath as required for selectively cooling or heating the patient in accordance with patient temperature measurements. The controller thermally decouples the catheter and patient from the fluid bath during changes in fluid bath temperatures in order to overcome the effects of system thermal mass.

Abstract: A group of multiple hollow fibers may be shaped to introduce angular divergence among the fibers, or to introduce a selected longitudinal oscillation into the fibers. In one shaping technique, the fibers are held in parallel while upper and lower crimping assemblies of parallel crimping bars are drawn together on opposite sides of the parallel fibers. When bars of the opposing assemblies draw sufficiently close, they sandwich the fibers in between them, causing each fiber to assume a shape that oscillates as the fiber repeatedly goes over and then under successive bars. Since the crimping bars are aligned at oblique angles to the fibers, the peaks and troughs of successive fibers are offset. While in this position, the fibers are heated and then cooled to permanently retain their shapes. A different shaping technique utilizes a lattice of criss-crossing tines defining multiple apertures. In this technique, the lattice and fibers are positioned so that each fiber passes through one of the apertures.

Abstract: A patient control system uses a patient-implanted catheter in thermal communication with a fluid bath via a circulating fluid circuit. A controller automatically controls the temperature of the fluid bath as required for selectively cooling or heating the patient in accordance with patient temperature measurements. The controller thermally decouples the catheter and patient from the fluid bath during changes in fluid bath temperatures in order to overcome the effects of system thermal mass.

Abstract: A method of regulating the temperature of a patient by inserting a heat exchange catheter into a colon of a patient. The heat exchange catheter is inflated with a heat exchange fluid from a temperature control unit wherein the heat exchange fluid is not infused into the patient. The heat exchange catheter has a catheter body with an inflow lumen, an outflow lumen, and an irrigation lumen for irrigating the colon.

Abstract: A method for treating fever by establishing a closed loop pathway to flow a treatment substance through a patient's body without the substance entering the patient's bloodstream, by engaging a fever characteristic sensor with the patient, by receiving a signal from such sensor and using the controller to control temperature and/or flow of the treatment substance.

Abstract: Catheters adapted to exchange heat with a body fluid flowing through a body conduit employ helical elongate lumens for heat transfer with the body fluid. The helical elongate lumen of a catheter forms multiple turns extending longitudinally of a portion of the catheter with the turns each being bonded to the catheter along a fraction of the length of the turn. The length of the lumen and its orientation in each turn has the lumen otherwise displaced over a major portion of its length from the elongate body. The turns of the helical lumen can be arranged in sets having different lengths to encounter all areas of the flow. One or more infusion lumens may also extend to an infusion port or ports. The helical elongate lumen is defined by an elongate, thin-walled element. This lumen is in fluid communication with a heater/chiller supplying a working fluid for heat transfer through the wall of the elongate element defining the helical elongate lumen.

Abstract: A cardiopulmonary bypass patient is precooled using an indwelling catheter. Cardiopulmonary bypass is initiated when a target temperature or range are achieved, as determined by automatic temperature feedback provided to a control module. The patient may also be rewarmed at a controlled rate during or after termination of cardiopulmonary bypass such that faster and safer termination is realized.

Abstract: A method of regulating the temperature of a patient by inserting a heat exchange catheter into a colon of a patient. The heat exchange catheter is inflated with a heat exchange fluid from a temperature control unit wherein the heat exchange fluid is not infused into the patient. The heat exchange catheter has a catheter body with an inflow lumen, an outflow lumen, and an irrigation lumen for irrigating the colon.

Abstract: A catheter using multiple hollow fibers to carry a heating/cooling fluid employs fiber spreading features to improve heat transfer and help prevent clotting of body fluids within which the catheter is immersed. The catheter includes a length of outer tube surrounding an inner tube. The inner tube conveys fluids in one direction, and the passageway between inner and outer tubes conveys fluids in the opposite direction. The inner and outer tubes have proximal distal ends. The distal end is closed, but the proximal end is open to permit introduction of a heating or cooling fluid into the inner tube, and withdrawal of the fluid from the passageway between the inner and outer tubes. At the tubes' distal end resides a proximal fluid transfer housing coupled to multiple hollow heat exchange fibers. The distal ends of these fibers may be commonly connected to a distal fluid transfer housing and optional reservoir, which cooperatively return fluid to the passageway between inner and outer tubes.

Abstract: A machine-driven automatic fever abatement system treats or prevents fever in hospital patients by administering medication, coolant, or other antipyretic means. The system includes a path, a flow device, a source of treatment substance, fever-characteristic sensors, and a controller. The path may be an open-ended structure, such as a tube, or a closed-ended structure such as a catheter with a sealed, internal path. The path is coupled to one or more bodily sites of the patient. The path is coupled to the flow device, which is itself attached to the source. The source contains a treatment substance such as medication (in the case of an open-ended path) or a coolant (in the case of a closed-ended path). One or more fever characteristic sensors are attached to various sites on the patient, for sensing temperature, metabolic rate, and/or other fever-affected physiological properties.

Abstract: A kit of parts comprises a system and instructions for use for controlling patient temperature which uses a central venous line catheter having a heat exchange element. The central venous line catheter is provided with one or more lumens for providing access to the central blood supply of the patient, and with additional lumens for communicating heat exchange fluid to the heat exchange element. Heat exchange fluid temperature is controlled through a feed back loop in which patient temperature is sensed and used to control a temperature control unit comprising a heating device and/or a cooling device in heat exchange relationship with the heat exchange fluid. A tubing set transports the heat exchange fluid between the central venous line and the temperature control unit, with a pump serving to circulate the fluid in a closed fluid circuit in the system.

Abstract: A catheter using multiple hollow fibers to carry a heating/cooling fluid employs fiber spreading features to improve heat transfer and help prevent clotting of body fluids within which the catheter is immersed. The catheter includes a length of outer tube surrounding an inner tube. The inner tube conveys fluids in one direction, and the passageway between inner and outer tubes conveys fluids in the opposite direction. The inner and outer tubes have proximal distal ends. The distal end is closed, but the proximal end is open to permit introduction of a heating or cooling fluid into the inner tube, and withdrawal of the fluid from the passageway between the inner and outer tubes. At the tubes' distal end resides a proximal fluid transfer housing coupled to multiple hollow heat exchange fibers. The distal ends of these fibers may be commonly connected to a distal fluid transfer housing and optional reservoir, which cooperatively return fluid to the passageway between inner and outer tubes.

Abstract: A group of multiple hollow fibers may be shaped to introduce angular divergence among the fibers, or to introduce a selected longitudinal oscillation into the fibers. In one shaping technique, the fibers are held in parallel while upper and lower crimping assemblies of parallel crimping bars are drawn together on opposite sides of the parallel fibers. When bars of the opposing assemblies draw sufficiently close, they sandwich the fibers in between them, causing each fiber to assume a shape that oscillates as the fiber repeatedly goes over and then under successive bars. Since the crimping bars are aligned at oblique angles to the fibers, the peaks and troughs of successive fibers are offset. While in this position, the fibers are heated and then cooled to permanently retain their shapes. A different shaping technique utilizes a lattice of crisscrossing tines defining multiple apertures. In this technique, the lattice and fibers are positioned so that each fiber passes through one of the apertures.

Abstract: Processes for forming a uniform, continuous coating of heparin covalently bonded to blood-contacting polyvinylchloride surfaces of a medical device are disclosed. These processes include coating the polyvinylchloride surfaces with an organic solvent solution of heparin complexed with an organic cation, and then exposing the coated surfaces to ionizing radiation to covalently bind the heparin moiety to the polyvinylchloride. The complex of the coating is formed from a heparin moiety and at least one cationic moiety selected from the group consisting of dimethylstearylamine, polyethyleneimine, benzalkonium, stearylkonium, and tridodecylmethylammonium; the complex is soluble in organic solvents and forms continuous and uniform coatings on polyvinylchloride. Advantageously, the heparin moiety can be bonded to the polyvinylchloride surfaces simultaneously with sterilizing the medical devices using ionizing radiation.