Abstract: Embodiments described herein provide a system and method for secure delivery of assets to a trusted device. Multiple levels of verification are implemented to enable components of a software update and asset delivery system to verify other components within the system. Furthermore, updates are provided only to client devices that are authorized to receive such updates. In one embodiment, the specific assets provided to a client device during a software update can be tailored to the client device, such that individual client devices can receive updated versions of software asset at a faster or slower rate than mass market devices. For example, developer or beta tester devices can receive pre-release assets, while enterprise devices can receive updates at a slower rate relative to mass market devices.

Abstract: The present disclosure provides compositions and methods for the treatment or prophylaxis of a perfusion disorder, such as ischemia and/or reperfusion injury, in a subject's organ, tissue or extremity by preserving or improving endothelial function, reducing vascular injury, and/or promoting vascular repair. The disclosed compositions comprise endothelial colony-forming cells or a serum-free composition comprising chemically defined media conditioned by endothelial colony-forming cells.

Abstract: Disclosed are methods to treat a renal disorder in a mammal in need thereof by administering to the mammal in need of treatment an effective amount of a store operated calcium entry (SOCE) inhibitor or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure provides compositions and methods for the treatment or prophylaxis of a perfusion disorder, such as ischemia and/or reperfusion injury, in a subject's organ, tissue or extremity by preserving or improving endothelial function, reducing vascular injury, and/or promoting vascular repair. The disclosed compositions comprise endothelial colony-forming cells or a serum-free composition comprising chemically defined media conditioned by endothelial colony-forming cells.