Patents by Inventor David P. Labeda

David P. Labeda has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHOSPHONIC ACID COMPOUNDS AND SCREENING METHOD
    Publication number: 20170202863
    Abstract: The present invention relates to pharmaceutical compositions comprising a phosphonic acid compound, such as a natural product. Such compounds can include, such as an antibiotic or compound with other activity, derived from an Actinobacteria strain having a gene encoding pepM (phosphoenolpyruvate phosphomutase) or a pepM-dependent biosynthetic pathway. The present invention also relates to methods for treating or preventing or reducing the risk of a bacterial infection by administering a therapeutically effective or prophylactically effective amount of a phosphonic acid antibiotic, or a pharmaceutical composition containing such an antibiotic, to a patient or subject in need thereof. The present invention further relates to methods for isolating, purfying, and identifying such phosphonic acid compounds from Actinobacteria strains.
    Type: Application
    Filed: July 21, 2015
    Publication date: July 20, 2017
    Inventors: William W. Metcalf, Kou-San Ju, Jiangtao Gao, James R. Doroghazi, David P. Labeda, Wilfred A. van der Donk
  • MACROLIDES AND METHODS FOR PRODUCING SAME
    Publication number: 20110144176
    Abstract: This invention relates, in part, to macrolide compounds, actinomycete strains for producing them, and pharmaceutical compositions containing them.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 16, 2011
    Applicant: Wyeth LLC
    Inventors: Mia Haruna Yoshino SUMMERS, Edmund Idris Graziani, Margaret M. Leighton, Kevin Pong, Roger Alan Kele, David P. Labeda
  • Macrolides and methods for producing same
    Patent number: 7247650
    Abstract: This invention relates, in part, to macrolide compounds, actinomycete strains for producing them, and pharmaceutical compositions containing them.
    Type: Grant
    Filed: February 25, 2005
    Date of Patent: July 24, 2007
    Assignee: Wyeth
    Inventors: Mia Haruna Yoshino Summers, Edmund Idris Graziani, Margaret M. Leighton, Kevin Pong, Roger Alan Kele, David P. Labeda
  • Antibiotic LL-D37187.alpha.
    Patent number: 5432193
    Abstract: This invention relates to antibiotic LL-D37187.alpha. derived from the microorganism Streptomyces which is useful as an antibacterial agent.
    Type: Grant
    Filed: May 14, 1993
    Date of Patent: July 11, 1995
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Gerhard Schlingmann, David P. Labeda, Joseph J. Goodman
  • Subspecies of Micromonospora citrea which produces antibiotic LL-E19085 alpha
    Patent number: 5223430
    Abstract: This disclosure describes novel antibacterial agents designated LL-E10985.alpha., LL-E19085.beta., LL-E19085.gamma., LL-E19085.zeta. and LL-E19085.eta., having the structure: ##STR1## their production by aerobic fermentation of a new subspecies of Micromonospora citrea NRRL 18351 and mutants thereof, and the isolation and purification thereof.
    Type: Grant
    Filed: October 28, 1991
    Date of Patent: June 29, 1993
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Joseph J. Goodman, David P. Labeda
  • Antitumor antibiotics (LL-E33288 complex)
    Patent number: 5108912
    Abstract: Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora spp. calichensis NRRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
    Type: Grant
    Filed: September 10, 1990
    Date of Patent: April 28, 1992
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Michael Greenstein, David P. Labeda, Amedeo A. Fantini
  • Antibiotic LL-E19085
    Patent number: 5096907
    Abstract: This disclosure describes novel antibacterial agents designated LL-E10985.alpha., LL-E19085.beta., LL-E19085.gamma., LL-E19085.gamma. and LL-E19085.zeta., having the structure: ##STR1## their production by aerobic fermentation of a new subspecies of Micromonospora citrea NRRL 18351 and mutants thereof, and the isolation and purification thereof.
    Type: Grant
    Filed: January 9, 1991
    Date of Patent: March 17, 1992
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Joseph J. Goodman, David P. Labeda
  • Antitumor antibiotics (LL-E33288 complex)
    Patent number: 4970198
    Abstract: Antibacterial and antitumor agents designated LL-E33288 complex and their production by new strains of Micromonospora echinospora ssp. calichensis NNRL-15839, NRRL-15975 and NRRL-18149, are disclosed.
    Type: Grant
    Filed: January 30, 1987
    Date of Patent: November 13, 1990
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Michael Greenstein, David P. Labeda, Amedeo A. Fantini
  • Antibiotic LL-C19004
    Patent number: 4870019
    Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
    Type: Grant
    Filed: November 21, 1986
    Date of Patent: September 26, 1989
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Donald B. Borders, May D. Lee, William M. Maiese, Raymond T. Testa, David P. Labeda
  • Antibiotic LL-D42067.beta.
    Patent number: 4859598
    Abstract: Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
    Type: Grant
    Filed: January 21, 1986
    Date of Patent: August 22, 1989
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Donald B. Borders, Joseph J. Goodman, David P. Labeda
  • Culture and process for producing antibiotic LL-D42067alpha
    Patent number: 4774184
    Abstract: The invention is a process for the production by fermentation of the antibacterial and antiparasitic agents designated LL-D42067.alpha., to methods for its recovery and concentration from crude solutions and to processes for its purification. The invention includes within its scope the biologically pure culture of the antibiotic.
    Type: Grant
    Filed: August 14, 1985
    Date of Patent: September 27, 1988
    Assignee: American Cyanamid Company
    Inventors: Taikwang M. Lee, Donald B. Borders, Joseph J. Goodman, Raymond T. Testa, William M. Maiese, David P. Labeda
  • Antibiotic LL-C19004
    Patent number: 4699790
    Abstract: A new antibacterial agent designated LL-C19004 is described, which antibacterial agent is produced through microbiological fermentation, under controlled conditions using a new species of Saccharothrix, Saccharothrix espanaensis (NRRL 15764).
    Type: Grant
    Filed: September 13, 1985
    Date of Patent: October 13, 1987
    Assignee: American Cyanamid Company
    Inventors: Jane P. Kirby, Donald B. Borders, May D. Lee, William M. Maiese, Raymond T. Testa, David P. Labeda
  • Antibiotic LL-C23201.delta.
    Patent number: 4628046
    Abstract: This disclosure describes a new antibacterial agent designated LL-C23201.delta., produced in a microbiological fermentation under controlled conditions using a new strain of Streptomyces olivaceo-griseus, sp. nov. and mutants thereof. This new antibacterial agent is active against a variety of microorganisms and thus is useful in inhibiting the growth of such bacteria wherever they may be found.
    Type: Grant
    Filed: June 20, 1983
    Date of Patent: December 9, 1986
    Assignee: American Cyanamid Company
    Inventors: David P. Labeda, Joseph J. Goodman, John H. E. J. Martin, deceased
  • Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega..sub.1, LL-D49194.omega..sub.2, and LL-D49194.omega..sub.3
    Patent number: 4626503
    Abstract: Antitumor agents LL-D49194.alpha..sub.1, LL-D49194.beta..sub.1, LL-D49194.beta..sub.2, LL-D49194.beta..sub.3, LL-D49194.gamma., LL-D49194.delta., LL-D49194.epsilon., LL-D49194.xi., LL-D49194.eta., LL-D49194.omega., LL-D49194.omega..sub.2 and LL-D49194.omega..sub.3.
    Type: Grant
    Filed: February 14, 1985
    Date of Patent: December 2, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Amedeo A. Fantini, David P. Labeda, William M. Maiese, Raymond T. Testa, Donald B. Borders
  • Biologically pure culture of Streptomyces majorciensis Labeda
    Patent number: 4608343
    Abstract: This disclosure describes four new antibacterial agents designated LL-C08078.alpha..sub.1, LL-C08078.alpha..sub.2, LL-C08078.alpha..sub.3 and LL-C08078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.
    Type: Grant
    Filed: May 30, 1985
    Date of Patent: August 26, 1986
    Assignee: American Cyanamid Company
    Inventors: David P. Labeda, Joseph J. Goodman, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
  • Antibiotic LL-D42067.beta.
    Patent number: 4578468
    Abstract: Antibiotic LL-D42067.beta. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: March 25, 1986
    Assignee: American Cyanamid Company
    Inventors: Guy T. Carter, Donald B. Borders, Joseph J. Goodman, David P. Labeda
  • Preparation of antibiotic LL-D05139.beta. from cultures of Glycomyces harbinensis, gen. nov., sp. nov.
    Patent number: 4568646
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139.beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: January 24, 1985
    Date of Patent: February 4, 1986
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa
  • Antibiotic LL-D42067.alpha.
    Patent number: 4551533
    Abstract: Antibiotic LL-D42067.alpha. derived by aerobic fermentation of the microorganism Actinomadura madurae subspecies simaoensis NRRL 15734, useful as an antibacterial and antiparasitic agent.
    Type: Grant
    Filed: March 26, 1984
    Date of Patent: November 5, 1985
    Assignee: American Cyanamid Company
    Inventors: Taikwang M. Lee, Donald B. Borders, Joseph J. Goodman, Raymond T. Testa, William M. Maiese, David P. Labeda
  • Antibacterial antibiotics LL-CO8078.alpha..sub.1, .alpha..sub.2, .alpha..sub.3 and .beta.
    Patent number: 4534970
    Abstract: This disclosure describes four new antibacterial agents designated LL-CO8078.alpha..sub.1, LL-CO8078.alpha..sub.2, LL-CO8078.alpha..sub.3 and LL-CO8078.beta. produced in a microbiological fermentation under controlled conditions using a new strain of a new species of the genus Streptomyces called Streptomyces majorciensis Labeda, sp. nov., and mutants thereof. These new antibacterial agents are active against a variety of microorganisms and thus are useful in inhibiting the growth of such bacteria wherever they may be found. In addition, these agents are active as growth promotants in warm-blooded animals.
    Type: Grant
    Filed: June 23, 1983
    Date of Patent: August 13, 1985
    Assignee: American Cyanamid Company
    Inventors: David P. Labeda, Joseph J. Goodman, Donald B. Borders, Raymond T. Testa, John H. E. J. Martin, deceased
  • Antibiotic LL-D05139 .beta.
    Patent number: 4503044
    Abstract: This disclosure describes a new antibacterial and anti-tumor agent designated LL-D05139 .beta., produced in a microbiological fermentation under controlled conditions using a new genus Glycomyces harbinensis gen. nov., sp. nov., and mutants thereof.
    Type: Grant
    Filed: April 25, 1983
    Date of Patent: March 5, 1985
    Assignee: American Cyanamid Company
    Inventors: May D. Lee, Donald B. Borders, David P. Labeda, Amedeo A. Fantini, Raymond T. Testa