Abstract: A system includes memory, and processing circuitry coupled to the memory, the processing circuitry configured to: determine at least one of: a cross-electrical signal measurement at a first electrode on a first lead implanted within a tongue of the patient based on a stimulation signal between a second electrode on the first lead or a second lead implanted within the tongue of the patient and a third electrode, or a strain measurement of at least one of the first lead or the second lead. The processing circuitry is configured to determine movement of the tongue based on at least one of the cross-electrical signal measurement or the strain measurement, and generate information indicative of the movement of the tongue.

Abstract: An example system includes a first lead configured to be positioned in or beside a left internal jugular vein (IJV) of a patient to deliver a first stimulation signal to a first vagus nerve, the first lead including one or more first segmented electrodes positioned on a distal portion of the first lead and a first anchoring mechanism; a second lead configured to be positioned in or beside a right IJV of the patient to deliver a second stimulation signal to a second vagus nerve, the second lead including one or more second segmented electrodes positioned on a distal portion of the second lead and a second anchoring mechanism; and circuitry configured to deliver electrical energy to the first lead to deliver the first stimulation signal and the second lead to deliver the second stimulation signal to provide bilateral stimulation to the first vagus nerve and the second vagus nerve.

Abstract: Provided herein are methods of separating host cell lipases from a production protein in chromatographic processes and methods of improving polysorbate-80 stability in a production protein formulation by separating host cell lipases from the production protein using chromatographic processes. Also provided herein are compositions comprising antibodies or antigen binding fragments thereof that bind to cytotoxic T lymphocyte associated antigen 4 (CTLA4). In another aspect, such compositions further comprise a reduced level of host cell proteins and/or increased level of polysorbate-80 (PS-80) stability.

Abstract: A system includes any number of solid-state circuit breakers that couple between a power supply and an electrical load. The system also includes a housing and the solid-state circuit breakers are disposed within the housing. The housing includes a door sensor that generates a first signal indicative of a position of a door of the housing. The housing also includes an indicator that generates a second signal indicative of a position of a handle of the housing. The system also includes a secondary device communicatively coupled to the solid-state circuit breakers, the door sensor, and the indicator. The secondary device receives the first signal and the second signal and generates an instruction to adjust an operating state of the solid-state circuit breakers based on the first signal and the second signal.

Abstract: An example system includes a collar; a first stimulating electrode array positioned on the collar and configured to delivery stimulation therapy to a patient; a second stimulating electrode array being positioned on the collar and configured to deliver stimulation therapy to the patient; a sensor array being positioned on the collar and configured to detect one or more features indicative of laryngeal muscle activity of the patient; and a controller configured to control stimulation therapy to be delivered via the first stimulating electrode array and the second stimulating electrode array.

Abstract: The present disclosure provides for synchronization of multi-core systems by monitoring a plurality of debug trace data streams for a redundantly operating system including a corresponding plurality of cores performing a task in parallel; in response to detecting a state difference on one debug trace data stream of the plurality of debug trace data streams relative to other debug trace data streams of the plurality of debug trace data streams: marking a given core associated with the one debug trace data stream as an affected core; and restarting the affected core.

Abstract: The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.

Abstract: The present disclosure relates to viral vaccine formulations with enhanced stability and methods of use thereof.

Abstract: The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.

Abstract: The present disclosure relates to methods of monitoring bladder cancer patients and analyzing patient samples for presence of methylated DNA and optionally particular gene mutations. In some embodiments, analysis results are correlated with clinical outcome measures such as risk of bladder cancer recurrence.

Abstract: The present disclosure relates to viral vaccine formulations with enhanced stability and methods of use thereof.

Abstract: Systems and methods for reducing engine emissions in a locomotive are presented. In an embodiment, a fuel injector or a fuel injection pump of a fuel injection mechanism includes a plunger with an upper helix whose angle changes between points on the plunger that correspond to an idle throttle position and a full throttle position. As such, injection timing is optimized, and engine emissions are reduced.

Abstract: Systems and methods for reducing engine emissions in a locomotive are presented. In an embodiment, a fuel injector or a fuel injection pump of a fuel injection mechanism includes a plunger with an upper helix whose angle changes between points on the plunger that correspond to an idle throttle position and a full throttle position. As such, injection timing is optimized, and engine emissions are reduced.

Abstract: Systems and methods for reducing engine emissions in a locomotive are presented. In an embodiment, a fuel injector or a fuel injection pump of a fuel injection mechanism includes a plunger with an upper helix whose angle changes between points on the plunger that correspond to an idle throttle position and a full throttle position. As such, injection timing is optimized, and engine emissions are reduced.

Abstract: Systems and methods for reducing engine emissions in a locomotive are presented. In an embodiment, a fuel injector or a fuel injection pump of a fuel injection mechanism includes a plunger with an upper helix whose angle changes between points on the plunger that correspond to an idle throttle position and a full throttle position. As such, injection timing is optimized, and engine emissions are reduced.

Abstract: A one-piece toilet seat hinge composed of an elastomeric material throughout, and having the characteristics of rubber, and including a flat flange member and a coplanar support shank, the flange member being designed to be connected to the toilet seat and the support shank being generally cylindrical in shape and externally threaded to facilitate mounting thereof within a cavity normally found on the toilet stool for connection of the seat thereto. The flange member has lower peripheral portions having sufficient memory to cause the toilet seat to swing from a horizontal orientation, upon release, to a vertically extending orientation, thereby obviating the likelihood of the seat being soiled by a subsequent male urinator.

Abstract: A Sleeve Valve for regulating the water level in ponds, lagoons and other wetlands which includes an outer tubular section of plastic pipe with a plurality of vertically spaced openings and an inner tubular section of plastic pipe that is disposed telescopically within, and rotatable relative to, the outer tubular pipe. This inner tubular pipe includes a plurality of vertically spaced openings that are positionally staggered about a circumference and arranged for selective alignment with one of the openings in the outer pipe. Each of the openings in the outer pipe are sealed against the outer wall of the inner pipe until rotation of the inner pipe causes alignment of a selected opening in the outer pipe with a corresponding opening in the inner pipe, thereby allowing water to pass only through such corresponding aligned openings. The water level is regulated by selecting and aligning corresponding openings in the outer and inner pipes at the water level desired.

Abstract: A method for producing and using oak chips or other divided forms of the oak for aging wine is described. The chips or other divided forms are provided in a permeable container. In particular a method is described for removing undesirable flavors from the oak by soaking the oak in an aqueous solution of water or water and ethanol and toasting the oak to enhance desirable flavors prior to or after the soaking. The method produces wines which are comparable to the best barrel aged wines.