Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.

Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.

Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.

Abstract: Embodiments of the present invention are directed to methods and devices for minimizing band spreading of compositions separated by chromatographic processes. One embodiment of the present invention features a device (11) for holding a separation column or cartridge. The device (11) includes a housing (15) having a chamber for receiving one or more columns or cartridges. The columns and cartridges have an inlet for receiving fluid and an outlet for discharging fluid and a column axis corresponding generally with the flow of fluid from the inlet to the outlet. The columns and cartridges are suitable for performing separations in which a constant temperature is desirable. The housing (15) further includes a heating element for maintaining said chamber at a constant temperature. The device (11) further includes positioning means (17) for placing the column and cartridge outlet in proximity to a detector.

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample. An emitter assembly includes having a deformable end portion, an inlet near the deformable end portion to receive the sample eluent from the microfluidic substrate, and an electrically conductive outlet portion to emit a spray of the sample eluent. A force-applying unit applies a force to the emitter assembly that urges the deformable end portion into contact with the microfluidic substrate. The deformable end portion is more elastic than the microfluidic substrate so that the contact between the microfluidic substrate and the deformable end portion produces a substantially fluid-tight seal between the outlet aperture of the microfluidic substrate and the inlet of the emitter assembly.

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.

Abstract: An apparatus for chemical separations includes a microfluidic substrate having an outlet aperture for outputting an eluent of a sample, a spray unit having an inlet to receive the eluent and an outlet to emit a spray of the eluent, and a force-applying unit. The spray unit has a deformable portion defining the inlet and having an elastic modulus that is lower than an elastic modulus of the microfluidic substrate. The force-applying unit, such as a spring, is disposed to urge the deformable portion in contact with the substrate to form a substantially fluid-tight seal.

Abstract: A liquid-chromatography module includes a microfluidic cartridge housing a microfluidic substrate with a channel for transporting fluid. The microfluidic substrate has fluidic apertures through which fluid is supplied to the channel. One side of the cartridge has nozzle openings, each aligning with a fluidic aperture in the microfluidic substrate and receiving a fluidic nozzle. A clamping assembly has a plunger that is movable into a clamped position and an end housing that defines a chamber. One wall of the end housing has a fluidic block with fluidic nozzles extending into the chamber. A second wall has a slot through which the cartridge enters the chamber. When moved into the clamped position while the cartridge is in the chamber, the plunger urges the cartridge against the fluidic block such that each fluidic nozzle enters one nozzle opening and establishes fluidic communication with one fluidic aperture in the microfluidic substrate.

Abstract: An HPLC column holding apparatus used to mount an HPLC column in one of a plurality of positions is disclosed herein. The apparatus comprises a clip-device interface that secures the apparatus to a platform and a clip-column interface that secures the HPLC column to the apparatus.

Abstract: Embodiments of the present invention are directed to methods and devices for minimizing band spreading of compositions separated by chromatographic processes. One embodiment of the present invention features a device (11) for holding a separation column or cartridge. The device (11) includes a housing (15) having a chamber for receiving one or more columns or cartridges. The columns and cartridges have an inlet for receiving fluid and an outlet for discharging fluid and a column axis corresponding generally with the flow of fluid from the inlet to the outlet. The columns and cartridges are suitable for performing separations in which a constant temperature is desirable. The housing (15) further includes a heating element for maintaining said chamber at a constant temperature. The device (11) further includes positioning means (17) for placing the column and cartridge outlet in proximity to a detector.

Abstract: An I/O device in the form of an internal dongle includes a body having connective structure being arranged to removably attach the body to a housing of an electronic device. The dongle also includes a circuit assembly that has an exterior connector on the body for electrically connecting to a second electronic device, a dongle circuit being electrically coupled to the external connector through the body, an electronic cable having a first end electrically coupled to the dongle circuit, and a second end being structured and arranged to connect to an electronic component of the first mentioned electronic device within the housing.

Abstract: An article adapted to pass a cable through a housing includes a substantially solid body, including front and rear ends. A side surface of the body provides a groove extending into the body from the front to the rear end. The groove is sized to carry a selected size electric cable. The body also includes connective structure adapted to removably connect the body to the housing. The article also includes a sheet of nonconductive material extending across the groove at the front end of the body. The sheet provides a circular opening sized to allow the cable to pass therethrough. The sheet also has a slit extending from the side surface to the circular opening. The sheet is fabricated of a resilient material and is structured to allow the cable to be inserted through the slit and into the circular opening such that the cable extends along the groove and extends into the housing from the rear end of the body when the body is connected to the housing.

Abstract: An I/O device in the form of an internal dongle includes a body having connective structure being arranged to removably attach the body to a housing of an electronic device. The dongle also includes a circuit assembly that has an exterior connector on the body for electrically connecting to a second electronic device, a dongle circuit being electrically coupled to the external connector through the body, an electronic cable having a first end electrically coupled to the dongle circuit, and a second end being structured and arranged to connect to an electronic component of the first mentioned electronic device within the housing.

Abstract: An industrial computing device includes a field mountable primary housing having a removable side cover to facilitate expansion. Within the primary housing there is a head board having a processor on one side. On the opposite side, there is an expansion connector adapted to receive an expansion board and at least one peripheral connector, which is coupled to the processor within the housing. The peripheral connector receives at least one PCMCIA card such that the PCMCIA card is also within the housing when plugged into the peripheral connector. The expansion board includes at least one more peripheral connector to receive at least one more PCMCIA card. The peripheral connector, the expansion connector and the side cover are oriented orthogonal to a mounting plane of the computing device. The primary housing can also include a removable front cover, which together with a top or bottom portion of the primary housing, provides an aperture for flush-mounting an I/O device in the form of an internal dongle.