Patents by Inventor David P. Sebesta

David P. Sebesta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
    Patent number: 7427678
    Abstract: This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides, using cycloaddition reactions, such as the Diels-Alder reaction. Included in this invention are the novel immobilized biomolecules that can be prepared according to the method of this invention.
    Type: Grant
    Filed: May 1, 2001
    Date of Patent: September 23, 2008
    Assignee: Sigma-Aldrich Co.
    Inventors: Wolfgang Pieken, Andreas Wolter, David P. Sebesta, Michael Leuck, Hallie A. Latham-Timmons, John Pilon, Gregory M. Husar
  • Method for immobilizing oligonucleotides employing the cycloaddition bioconjugation method
    Publication number: 20030215801
    Abstract: This invention discloses a novel method for immobilizing molecules to a support. Specifically, this invention discloses a method of immobilizing derivatized biomolecules, such as oligonucleotides, using cycloaddition reactions, such as the Diels-Alder reaction. Included in this invention are the novel immobilized biomolecules that can be prepared according to the method of this invention.
    Type: Application
    Filed: May 1, 2001
    Publication date: November 20, 2003
    Inventors: Wolfgang Pieken, Andreas Wolter, David P. Sebesta, Michael Leuck, Hallie A. Latham-Timmons, John Pilon, Gregory M. Husar
  • Method of preparation of known and novel 2'-modified nucleosides by intramolecular nucleophilic displacement
    Patent number: 6090932
    Abstract: A method for the preparation of 2'-modified nucleosides is provided. The method comprises a novel intramolecular nucleophilic displacement reaction. Included in the invention are novel 2'-modified pyrimidines and purines prepared according to the method of the invention, novel pyrimidines and purines bearing a 2',3' heterocyclic substituent and oligonucleotides containing said 2'-modified pyrimidines and purines. The 2'-modified nucleosides are useful as anti-viral and anti-neoplastic agents.
    Type: Grant
    Filed: October 30, 1996
    Date of Patent: July 18, 2000
    Assignee: Proligo LLC
    Inventors: Danny P. McGee, Wolfgang A. Pieken, David P. Sebesta, Yansheng Zhai